公开(公告)号：GR3030952T3

公开(公告)日：1999-11-30

申请号：GR990402033

申请日：1999-08-11

Applicant: HOECHST AG

Inventor： VERTESY LASZLO DR ,  ARETZ WERNER DR ,  FEHLHABER HANS-WOLFRAM DR ,  GANGULI BIMAL NARESH DR

IPC: A61K31/70 ,  A61K31/7135 ,  A61P31/04 ,  C07H3/02 ,  C07H5/06 ,  C07H11/00 ,  C07H23/00 ,  C07K9/00 ,  C12N15/51 ,  C12P19/58 ,  C12P19/60 ,  C12R1/465 ,  A61K31/71 ,  C12N1/20 ,  C12P19/26

Abstract: Compounds of formula I, wherein R denotes = NOH (a), =O (b); -OH and -H (c), -NH2 and -H (d) or =N-O-R'(e); R' denotes phenyl or a branched or unbranched alkyl with 1 to 10 carbon atoms, R'' denotes H, alkyl, hydroxy-alkyl and amino-alkyl, as well as the chemical equivalents and physiologically acceptable salts thereof. The salmycins and their derivatives are used as a pharmaceutical.

公开(公告)号：GR3021611T3

公开(公告)日：1997-02-28

申请号：GR960402906

申请日：1996-11-14

Applicant: HOECHST AG

Inventor： ARETZ WERNER DR ,  FURRER HARALD DR ,  GEBERT ULRICH DR ,  HINZE HEINZ-JOACHIM

IPC: A61K31/52 ,  A61K31/522 ,  A61P9/00 ,  C07B37/10 ,  C07D473/04 ,  C07D473/06 ,  C07D473/08 ,  C07D473/10 ,  C12N1/16 ,  C12P17/18 ,  C12P41/00 ,  C12R1/645

Abstract: A Rhodotorula rubra strain which reduces pentoxifylline 100% to the S-alcohol has been found. It is furthermore possible also to convert other oxoalkylxanthine derivatives into the corresponding S-alcohol. The microbiologically obtained S-(+) enantiomers can then be converted stereoselectively into the relevant R-(-) enantiomers. The corresponding S-alcohols and the R-alcohols obtained by enantioselective inversion of configuration bring about an increase in cerebral blood flow.

公开(公告)号：DE4337787A1

公开(公告)日：1995-05-11

申请号：DE4337787

申请日：1993-11-05

Applicant: HOECHST AG

Inventor： ARETZ WERNER DR ,  WILLEMS PHILIPP

IPC: C12N15/09 ,  C12M1/36 ,  C12N1/00 ,  C12N1/20 ,  C12N1/21 ,  C12N9/10 ,  C12N9/80 ,  C12R1/19 ,  C12P1/00 ,  C12P1/04

Abstract: Oxygen-dependent microorganisms can advantageously be fermented when the carbon feeding takes places as a function of the oxygen transfer rate.

公开(公告)号：DE4337630A1

公开(公告)日：1995-05-11

申请号：DE4337630

申请日：1993-11-04

Applicant: HOECHST AG

Inventor： ARETZ WERNER DR ,  HEDTMANN UDO DR

IPC: C07C59/60 ,  C07H3/06 ,  C07H13/12 ,  C12P7/42 ,  A61K31/71 ,  C07C51/42 ,  C07C59/76 ,  C12N1/16

Abstract: The invention relates to MA of the formula I in which R , R , R and R independently of one another are a hydroxyl group or hydrogen and R is hydrogen, the bond between the C atom carrying the substituent R and the C atom carrying the substituent R being a single bond, or R and R independently of one another are a hydroxyl group or hydrogen and R is hydrogen, the bond between the C atom carrying the substituent R and the C atom carrying the substituent R being a double bond or R , R and R independently of one another are a hydroxyl group or hydrogen and R and R together are an oxo group. MA is hydroxylated or oxidised in the lipid side chain by microorganisms of the genus Cryptococcus and in this form is a starting compound for the preparation of moenomycin analogues which can be employed as medicaments. The moenomycin analogues have the following chemical structure: in which R to R have the abovementioned meanings.A

公开(公告)号：CS80492A3

公开(公告)日：1992-10-14

申请号：CS80492

申请日：1992-03-17

Applicant: HOECHST AG

Inventor： KOLLER KLAUS-PETER DR ,  RIESS GUNTHER JOHANNES DR ,  ARETZ WERNER DR

IPC: C12N9/80 ,  C12N15/09 ,  C12N15/55 ,  C12P21/00 ,  C12R1/19 ,  C12R1/38 ,  C12N15/70

Abstract: The gene which encodes glutaryl acylase (GA) and is contained in the plasmid pCM145 (DSM 6409) permits the expression of GA in E. coli in high yields.

公开(公告)号：DE3483509D1

公开(公告)日：1990-12-06

申请号：DE3483509

申请日：1984-09-07

Applicant: HOECHST AG

Inventor： ARETZ WERNER DR ,  SAUBER KLAUS DR

IPC: C12N1/16 ,  C12N9/06 ,  C12P7/40 ,  C12P41/00 ,  C12R1/645

Abstract: Yeasts of the genus cryptococcus, preferably of the species C. Laurentii, form, in the presence of aminoacids, an L-aminoacid oxidase which stereospecifically converts L-aminoacids and their derivatives into the corresponding alpha -ketoacids. The immobilized cells are advantageously used for this conversion, which can also be used to resolve racemates.

公开(公告)号：AT57957T

公开(公告)日：1990-11-15

申请号：AT84110666

申请日：1984-09-07

Applicant: HOECHST AG

Inventor： ARETZ WERNER DR ,  SAUBER KLAUS DR

IPC: C12N1/16 ,  C12N9/06 ,  C12P7/40 ,  C12P41/00 ,  C12R1/645

公开(公告)号：DE3842025A1

公开(公告)日：1990-07-05

申请号：DE3842025

申请日：1988-12-14

Applicant: HOECHST AG

Inventor： THEN JOHANN DR ,  ARETZ WERNER DR ,  SAUBER K DR

IPC: C12N9/10 ,  C12P9/00 ,  C12P13/04 ,  C12P41/00 ,  C12R1/10 ,  C12R1/19

Abstract: L-2-amino-4-methylphosphinobutyric acid can be prepared by racemate resolution in the presence of D-amino-acid transaminase and L-amino- acid transaminase by reaction with alpha -keto acids and amino-group donors.

公开(公告)号：DE3573263D1

公开(公告)日：1989-11-02

申请号：DE3573263

申请日：1985-07-01

Applicant: HOECHST AG

Inventor： ARETZ WERNER DR ,  BERSCHEID HANS GERD DR ,  FEHLHABER HANS-WOLFRAM DR ,  BOTTGER DIRK DR ,  KRAEMER HANS PETER DR

IPC: C07C50/36 ,  A61K31/12 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07C45/00 ,  C07C67/00 ,  C07H15/252 ,  C12P7/26 ,  C12P19/56 ,  C12R1/465

Abstract: 1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Compounds of the formula I see diagramm : EP0167954,P12,F1 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod and their physiologically acceptable acid addition salts. 1. Claims for the Contracting State : AT A process for the preparation of a compound of the formula I see diagramm : EP0167954,P12,F2 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod, and their physiologically acceptable acid addition salts, which comprises fermenting the microorganism Streptomyces purpurascens (DSM 2658) in the presence of a nutrient medium with an elevated oxygen supply, otherwise in a customary manner under aerobic conditions, and isolating the compounds formed from the culture liquid and the mycelium by extraction with organic solvents followed by chromatography or partition in a customary manner.

公开(公告)号：DE3743323A1

公开(公告)日：1989-06-29

申请号：DE3743323

申请日：1987-12-21

Applicant: HOECHST AG

Inventor： ARETZ WERNER DR ,  SAUBER KLAUS DR

IPC: C12N9/10 ,  C12N9/52 ,  C12P13/04 ,  C12P17/18 ,  C12P35/02 ,  C12R1/125

Abstract: gamma -Glutamyltranspeptidase, which can be prepared by fermentation, can be used to hydrolyse alpha -aminoadipinyl-monoamino compounds, especially D-( delta )- alpha -aminoadipinyl-7-aminocephalosporanic acid.