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公开(公告)号：CY2121B1
公开(公告)日：2002-04-26
申请号：CY9800042
申请日：1998-10-16
Applicant: HOECHST AG
Inventor： STUEBER WERNER , KOSCHINSKY RAINER , DICKNEITE GERHARD , CENEK KOLAR
IPC: A61K38/00 , A61K38/05 , A61P7/02 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/072 , C07K9/00 , G01N33/53 , A61K37/02
Abstract: Amidinophenylalanine derivatives of the formula I the synthesis of these compounds, the use thereof and pharmaceutical compositions which contain these compounds are described.
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公开(公告)号：ZA8707561B
公开(公告)日：1988-05-25
申请号：ZA8707561
申请日：1987-10-08
Applicant: HOECHST AG
Inventor： KOENIG WOLFGANG , WOLFGANG KOENIG , SANDOW JUERGEN KURT , JUERGEN KURT SANDOW , KOLAR CENEK , CENEK KOLAR
IPC: A61K38/00 , A61K38/04 , A61P5/00 , A61P9/12 , C07K7/06 , C07K7/23 , C07K9/00 , C07K14/575 , C07K , A61K
CPC classification number: C07K7/23 , A61K38/00 , Y10S514/80
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Patent Agency Ranking
公开(公告)号：ZA899509B
公开(公告)日：1990-08-29
申请号：ZA899509
申请日：1989-12-13
Applicant: HOECHST AG
Inventor： KOLAR CENEK , CENEK KOLAR , KOENIG WOLFGANG , WOLFGANG KOENIG , SANDOW JUERGEN KURT , JUERGEN KURT SANDOW
Abstract: Peptides of the formula Ac-D-Nal(2)-D-Phe-D-Phe-Ser-X-D-Ser(Rha)-Leu-Arg-Pro-Y in which X represents Tyr or His and Y represents Gly-NH2, D-Ala-NH2, Azgly-NH2 or NH-C2H5 are competitive antagonists of Gn-RH. They are used for the treatment of gonadotropin- and steroid-dependent diseases and are prepared by known methods of peptide chemistry.
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公开(公告)号：ZA8909509B
公开(公告)日：1990-08-29
申请号：ZA8909509
申请日：1989-12-13
Applicant: HOECHST AG
Inventor： KOLAR CENEK , CENEK KOLAR , KOENIG WOLFGANG , WOLFGANG KOENIG , SANDOW JUERGEN KURT , JUERGEN KURT SANDOW
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公开(公告)号：ZA9106097B
公开(公告)日：1992-04-29
申请号：ZA9106097
申请日：1991-08-02
Applicant: HOECHST AG
Inventor： KONIG WOLFGANG , WOLFGANG KONIG , SANDOW JURGEN , JURGEN SANDOW , KOLAR CENEK , CENEK KOLAR
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公开(公告)号：ZA877561B
公开(公告)日：1988-05-25
申请号：ZA877561
申请日：1987-10-08
Applicant: HOECHST AG
Inventor： KOENIG WOLFGANG , WOLFGANG KOENIG , SANDOW JUERGEN KURT , JUERGEN KURT SANDOW , KOLAR CENEK , CENEK KOLAR
IPC: A61K38/00 , A61K38/04 , A61P5/00 , A61P9/12 , C07K7/06 , C07K7/23 , C07K9/00 , C07K14/575 , C07K , A61K
Abstract: The invention relates to peptides of the formula in which X is absent or is hydrogen or acyl; A is Pgl, de-hydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; B is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp; D is Tyr, Arg of His; E is D-Ser(R1), beta -Asn, beta -Asp-OMe, D-Thi or -NH-CH(CH2R2)-CO-; F is Ser(R1), Leu, Trp or Phe; G is Gly-NH2, Aza-Gly-NH2, D-Ala-NH2 or NH-alkyl; R1 is glycosyl and R2 is hydrogen, acyl, aryl or heteroaryl. The invention also relates to methods for the preparation of these peptides, agents containing them and their use.
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公开(公告)号：ZA916097B
公开(公告)日：1992-04-29
申请号：ZA916097
申请日：1991-08-02
Applicant: HOECHST AG
Inventor： KONIG WOLFGANG , WOLFGANG KONIG , SANDOW JURGEN , JURGEN SANDOW , KOLAR CENEK , CENEK KOLAR
Abstract: Peptides of the formula in which X is alkanoyl, A is optionally substituted D-Na(2), D-Phe or D-Trp, B is optionally substituted D-Phe, C is D-Pal(3) or optionally substituted D-Phe or D-Trp, and D is Tyr or His, E is D-Ser(R ), F is Leu, Trp or Phe, G is L-Ser(R ), H is Gly-NH2, D-Ala-NH2 or azagly-NH2 and R is a glycosyl radical, have inhibitory effects on the formation of the gonadotropins lutropin and follitropin and thus also on the synthesis of testosterone and oestrogen. A process for the preparation of these peptides is described.
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