公开(公告)号：FI43719B

公开(公告)日：1971-03-01

申请号：FI215965

申请日：1965-09-08

Applicant: HOECHST AG

Inventor： HUBER G ,  SCHACHT U ,  TSCHESCHE R ,  DUPHORN I

IPC: C07G11/00 ,  C12P1/06 ,  C12D9/14 ,  C12D9/02

Abstract: 1,126,196. Moenomycin A, B and C. FARBWERKE HOECHST A.G. 9 Dec., 1965 [10 Dec., 1964], No. 52310/65. Heading C2A. The antibiotic moenomycin (Specification 977,327) is separated into its components A, B and C by column chromatography on silica gel using as eluting agents mixtures of watermiscible alcohols and aqueous ammonia or aqueous C 1-4 amines. Mixtures of n-propanol and SN.NH 4 OH are preferred in which the content of NH 4 OH is increased. First impurities and then the components are eluted, and are recovered from pooled fractions by the addition of a non-solvent e.g. ether. Pharmaceutical compositions comprise monomycin A, B and C or a physiologically tolerable salt thereof, in admixture or conjunction with a phermaceutically suitable carrier.

公开(公告)号：DK111413B

公开(公告)日：1968-08-19

申请号：DK482965

申请日：1965-09-20

Applicant: HOECHST AG

Inventor： TSCHESCHE R ,  DUPHORN I

IPC: C07G11/00 ,  C12P1/06 ,  C12D9/14

Abstract: 1,126,196. Moenomycin A, B and C. FARBWERKE HOECHST A.G. 9 Dec., 1965 [10 Dec., 1964], No. 52310/65. Heading C2A. The antibiotic moenomycin (Specification 977,327) is separated into its components A, B and C by column chromatography on silica gel using as eluting agents mixtures of watermiscible alcohols and aqueous ammonia or aqueous C 1-4 amines. Mixtures of n-propanol and SN.NH 4 OH are preferred in which the content of NH 4 OH is increased. First impurities and then the components are eluted, and are recovered from pooled fractions by the addition of a non-solvent e.g. ether. Pharmaceutical compositions comprise monomycin A, B and C or a physiologically tolerable salt thereof, in admixture or conjunction with a phermaceutically suitable carrier.

公开(公告)号：SE348108B

公开(公告)日：1972-08-28

申请号：SE1203965

申请日：1965-09-16

Applicant: HOECHST AG

Inventor： HUBER G ,  SCHACHT U ,  TSCHESCHE R ,  DUPHORN I

IPC: C07G11/00 ,  C12P1/06 ,  A61K21/00

Abstract: 1,126,196. Moenomycin A, B and C. FARBWERKE HOECHST A.G. 9 Dec., 1965 [10 Dec., 1964], No. 52310/65. Heading C2A. The antibiotic moenomycin (Specification 977,327) is separated into its components A, B and C by column chromatography on silica gel using as eluting agents mixtures of watermiscible alcohols and aqueous ammonia or aqueous C 1-4 amines. Mixtures of n-propanol and SN.NH 4 OH are preferred in which the content of NH 4 OH is increased. First impurities and then the components are eluted, and are recovered from pooled fractions by the addition of a non-solvent e.g. ether. Pharmaceutical compositions comprise monomycin A, B and C or a physiologically tolerable salt thereof, in admixture or conjunction with a phermaceutically suitable carrier.