公开(公告)号：US3475482A

公开(公告)日：1969-10-28

申请号：US3475482D

申请日：1966-05-24

Applicant: HOECHST AG

Inventor： EHRHART GUSTAV ,  LINDNER ERNST ,  OTT HEINRICH

IPC: A61K31/195 ,  C07C101/04 ,  A61K27/00

CPC classification number: A61K31/195

公开(公告)号：US3426028A

公开(公告)日：1969-02-04

申请号：US3426028D

申请日：1965-11-16

Applicant: HOECHST AG

Inventor： EHRHART GUSTAV ,  THER LEOPOLD ,  ALPERMANN HANS-GEORG ,  OTT HEINRICH

IPC: C07D211/62 ,  C07D211/64 ,  C07D29/24 ,  C07D29/10

CPC classification number: C07D211/62 ,  C07D211/64

公开(公告)号：US3577424A

公开(公告)日：1971-05-04

申请号：US86793269

申请日：1969-10-20

Applicant: HOECHST AG

Inventor： EHRHART GUSTAV ,  SCHMITT KARL ,  HOFFMANN IRMGARD ,  OTT HEINRICH

IPC: C07D217/02 ,  C07D217/04 ,  C07D217/14 ,  C07D217/16 ,  C07D35/38

CPC classification number: C07D217/16 ,  C07D217/02 ,  C07D217/04 ,  C07D217/14

Abstract: 4-PHENYL-8-AMINO TETRAHYDROISOQUINOLINES HAVING CENTRALLY STIMULATING AND THYMOLEPTIC ACTION. METHODS FOR THEIR MANUFACTURE BY RING CLOSURE, ACYLATION, OR REDUCTION. PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS.

公开(公告)号：US3565955A

公开(公告)日：1971-02-23

申请号：US3565955D

申请日：1967-10-23

Applicant: HOECHST AG

Inventor： EHRHART GUSTAV ,  LINDNER ERNST ,  OTT HEINRICH

IPC: C07C93/08

CPC classification number: B41M5/136

Abstract: BASICALLY SUBSTITUTED DIPHENYL-METHYL ETHERS OF THE FORMULA

1-((R-PHENYL)-CH(-PHENYLENE-R1)-O-CH2-CH2-N(-CH3)-

CH(-CH3)-CH2-),3-(CH3-O-),R4-BENZENE

IN WHICH R AND R1 ARE HYDROGEN, CHLORINE, BROMINE, HYDROXYL, ALKYL OF 1 TO 3 CARBON ATOMS, OR ALKOXY OF 1 TO 3 CARBON ATOMS, AND R4 IS HYDROGEN OR METHOXY HAVING BENEFICIAL PHYSIOLOGICAL ACTIVITY IN THE TREATMENT OF HEART AND CIRCULATORY DISEASES.

公开(公告)号：US3474140A

公开(公告)日：1969-10-21

申请号：US3474140D

申请日：1967-08-08

Applicant: HOECHST AG

Inventor： EHRHART GUSTAV ,  LEDITSCHKE HEINRICH ,  MEIXNER WILLI ,  RUSCHIG HEINRICH

IPC: A61K31/195 ,  C07C233/00 ,  C07C103/22

CPC classification number: A61K31/195 ,  C07C233/00

公开(公告)号：US3468952A

公开(公告)日：1969-09-23

申请号：US3468952D

申请日：1966-05-03

Applicant: HOECHST AG

Inventor： EHRHART GUSTAV ,  GERICKE DIETMAR ,  OTT HEINRICH

IPC: A61K31/195 ,  C07C233/45 ,  C07C103/32

CPC classification number: A61K31/195 ,  C07C233/45

公开(公告)号：US3462456A

公开(公告)日：1969-08-19

申请号：US3462456D

申请日：1967-08-07

Applicant: HOECHST AG

Inventor： LEDITSCHKE HEINRICH ,  EHRHART GUSTAV ,  RUSCHIG HEINRICH ,  MEIXNER WILLI

IPC: C07D317/60 ,  C07D13/00

CPC classification number: C07D317/60

公开(公告)号：US3400155A

公开(公告)日：1968-09-03

申请号：US64727167

申请日：1967-04-25

Applicant: HOECHST AG

Inventor： EHRHART GUSTAV ,  LINDNER ERNST ,  OTT HEINRICH

IPC: C07D209/86 ,  C07D219/14 ,  C07D223/28 ,  C07D265/38 ,  C07D279/18

CPC classification number: C07D279/18 ,  C07D209/86 ,  C07D219/14 ,  C07D223/28 ,  C07D265/38

公开(公告)号：CA848456A

公开(公告)日：1970-08-04

申请号：CA848456D

Applicant: HOECHST AG

Inventor： LEDITSCHKE HEINRICH ,  EHRHART GUSTAV ,  MEIXNER WILLI ,  RUSCHIG HEINRICH

公开(公告)号：DE1568567A1

公开(公告)日：1970-03-19

申请号：DE1568567

申请日：1966-08-13

Applicant: HOECHST AG

Inventor： EHRHART GUSTAV ,  RUSCHIG HEINRICH ,  MEIXNER WILLI ,  LEDITSCHKE DR HEINRICH

IPC: A61K31/195 ,  C07C233/00 ,  C07C103/22

Abstract: 1,193,657. Substituted phenylacetamides. FARBWERKE HOECHST A.G. 11 Aug., 1967 [13 Aug., 1966], No. 37048/67. Heading C2C. Novel substituted phenylacetamides of the formula in which R 1 , R 2 and R 3 each represent an identical or different, saturated or unsaturated aliphatic hydrocarbon radical containing up to 4 carbon atoms are prepared by one of the following methods (a) Hydrolysis of an appropriately substituted phenylacetonitrile. (b) Reaction of ammonia on a suitably substituted phenylacetic acid or derivative thereof. (c) Dehydration of an ammonium salt of an appropriately substituted phenylacetic acid. (d) Hydrogenolysis of a suitably substituted N-benzyl- or N,N-dibenzyl-phenylacetamide. (e)Alkylation or alkenylation of an appropriately substituted 3-hydroxy-phenylacetamide. 3 - Hydroxyphenyldiethylacetamide is made by treating 3 - methoxyphenyldiethylacetamide with hydrobromic acid. 3 - Methoxyphenyldipropylacetonitrile is obtained by treating 3-methoxybenzyl cyanide with propyl bromide in the presence of sodium amide. Similarly using sec. butyl bromide, 3 - methoxyphenyl - ethyl - sec. butyl - acetonitrile is obtained from 3 - methoxy - phenyl - ethyl - acetonitrile which is in turn, obtained from 3- methoxybenzyl cyanide and ethyl bromide. Therapeutic compositions, having sedative properties and suitable for oral or parenteral administration, contain the above novel compounds as the active ingredient and pharmaceutically acceptable carriers.