公开(公告)号：JPH10279568A

公开(公告)日：1998-10-20

申请号：JP6266598

申请日：1998-03-13

Applicant: HOECHST AG

Inventor： FALK EUGEN ,  ENHSEN ALFONS ,  STENGELIN SIEGFRIED ,  GLOMBIK HEINER

IPC: C12N15/09 ,  A61K31/55 ,  A61K31/554 ,  A61K31/675 ,  A61K31/70 ,  A61K48/00 ,  A61P1/16 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P35/00 ,  C07D281/00 ,  C07D281/10 ,  C07D417/04 ,  C07D417/10 ,  C07D417/12 ,  C07F9/6558 ,  C07H17/00 ,  C12N5/00 ,  C12N5/10 ,  C12N9/12 ,  C12N15/06 ,  C12N15/10 ,  C12N15/11 ,  C12N15/54 ,  C12N15/85 ,  C12P21/02 ,  C12R1/91

Abstract: PROBLEM TO BE SOLVED: To obtain a new compound capable of reducing the concentration of an (ultra) low density lipoprotein cholesterol in plasma or serum and useful for treating and preventing hyperlipemia such as atherosclerosis. SOLUTION: This compound is represented by formula I R and R are each a straight-chain 1-6C alkyl; R is H or OR [R is H or a (substituted) 1-6C alkyl]; R is pyridyl or a (substituted) phenyl; R , R and R are each H, a halogen, cyano, etc.; R is represented by formula II (R is COOH, CH2 OH, etc.), etc.; X is NH or O; R and R are each H or 1-6C alkyl}. The objective compound is prepared by acylating or alkylating a compound represented by formula III at the group X-H according to the standard method or glycosylating or glucuronidating the compound represented by formula III at the group X-H and then eliminating the protecting group, especially hydroxyl group and amino functional group.

公开(公告)号：NO304653B1

公开(公告)日：1999-01-25

申请号：NO932159

申请日：1993-06-11

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER ,  WESS G NTHER

IPC: A61K31/575 ,  A61P1/00 ,  A61P3/00 ,  A61P3/06 ,  A61P7/00 ,  C07H9/00 ,  C07J9/00 ,  C07J41/00

Abstract: Bile acid derivatives of the formula I Z(X-GS)n in which GS, X, Z and n have the stated meanings, and a process for the production of these compounds are described. The compounds have pharmacological activity and can therefore be used as pharmaceuticals, in particular as hypolipidaemic.

公开(公告)号：HUT67574A

公开(公告)日：1995-04-28

申请号：HU9401408

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： WESS GUENTHER ,  KRAMER WERNER ,  ENHSEN ALFONS ,  GLOMBIK HEINER

IPC: A61K31/575 ,  A61K31/58 ,  A61P3/06 ,  A61P9/10 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00 ,  C07J51/00

Abstract: Monomeric bile acid derivatives of the formula I Z-X-GS I, in which GS, X and Z have the stated meanings, and processes for their preparation are described. The compounds have valuable pharmacological properties and can therefore be used as medicines.

公开(公告)号：AU6194994A

公开(公告)日：1994-11-10

申请号：AU6194994

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： GLOMBIK HEINER ,  ENHSEN ALFONS ,  KRAMER WERNER ,  WESS GUNTHER

IPC: A61K31/575 ,  A61K31/58 ,  A61P3/06 ,  A61P9/10 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00 ,  C07J51/00 ,  C07J17/00 ,  A61K31/565 ,  A61K31/66

Abstract: Monomeric bile acid derivatives of the formula I Z-X-GS I, in which GS, X and Z have the stated meanings, and processes for their preparation are described. The compounds have valuable pharmacological properties and can therefore be used as medicines.

公开(公告)号：AU6194694A

公开(公告)日：1994-11-10

申请号：AU6194694

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER ,  WESS GUNTHER

IPC: A61K31/575 ,  A61P3/06 ,  A61P9/00 ,  C07J3/00 ,  C07J7/00 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J51/00

Abstract: nor-Bile acid derivatives of the formula I G1 - X - G2 I, in which G1, G2 and X have the stated meanings, processes for preparing these compounds and medicines are described. On the basis of their pharmacological action, they can be used as antihyperlipidaemic.

公开(公告)号：NO941678L

公开(公告)日：1994-11-09

申请号：NO941678

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER ,  WESS GUNTHER

IPC: A61P3/06 ,  A61P9/00 ,  A61K31/575 ,  C07J3/00 ,  C07J7/00 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J51/00

Abstract: nor-Bile acid derivatives of the formula I G1 - X - G2 I, in which G1, G2 and X have the stated meanings, processes for preparing these compounds and medicines are described. On the basis of their pharmacological action, they can be used as antihyperlipidaemic.

公开(公告)号：NO941677L

公开(公告)日：1994-11-09

申请号：NO941677

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER ,  WESS GUNTHER

IPC: A61K31/575 ,  A61K31/58 ,  A61K31/675 ,  A61P3/06 ,  A61P9/10 ,  C07J9/00 ,  C07J17/00 ,  C07J41/00 ,  C07J43/00

Abstract: Tetrazole bile acid derivatives of the formula I G1 - X - G2 I in which G1, G2 and X have the stated meanings, and processes for their preparation are described. The compounds have valuable pharmacological properties and can therefore be used as medicines.

公开(公告)号：NO941677A

公开(公告)日：1994-11-09

申请号：NO941677

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER ,  WESS GUNTHER

IPC: A61K31/575 ,  A61K31/58 ,  A61K31/675 ,  A61P3/06 ,  A61P9/10 ,  C07J9/00 ,  C07J17/00 ,  C07J41/00 ,  C07J43/00

CPC classification number: C07J9/005 ,  C07J17/00 ,  C07J41/0005 ,  C07J41/0094 ,  C07J43/003

公开(公告)号：FI942077A

公开(公告)日：1994-11-09

申请号：FI942077

申请日：1994-05-05

Applicant: HOECHST AG

Inventor： GLOMBIK HEINER ,  ENHSEN ALFONS ,  KRAMER WERNER ,  WESS GUENTHER

IPC: A61K31/575 ,  A61K31/58 ,  A61P3/06 ,  A61P9/10 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00 ,  C07J51/00 ,  C07J17/00

Abstract: Monomeric bile acid derivatives of the formula I Z-X-GS I, in which GS, X and Z have the stated meanings, and processes for their preparation are described. The compounds have valuable pharmacological properties and can therefore be used as medicines.

公开(公告)号：CA2123051A1

公开(公告)日：1994-11-09

申请号：CA2123051

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER ,  WESS GUENTHER

IPC: A61K31/575 ,  A61P3/06 ,  A61P9/00 ,  C07J3/00 ,  C07J7/00 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J51/00

Abstract: nor-Bile acid derivatives, processes for their preparation and the use of these compounds as medicaments nor-Bile acid derivatives of the formula I G1 - X - G2 I in which G1, G2 and X have the meanings given, processes for the preparation of these compounds and medicaments are described. On the basis of their pharmacological action, they can be used as an antihyperlipidemic agent.