公开(公告)号：ZA8808734B

公开(公告)日：1989-07-26

申请号：ZA8808734

申请日：1988-11-22

Applicant: HOECHST AG

Inventor： FUELBERTH WERNER ,  WERNER FUELBERTH ,  LEEB RICHARD ,  RICHARD LEEB ,  RADAU MANFRED ,  MANFRED RADAU ,  STAMMBERGER WILLI ,  WILLI STAMMBERGER

IPC: A61K38/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/36 ,  A61K9/50 ,  A61K38/04 ,  A61K38/55 ,  A61K47/38 ,  A61P9/12 ,  A61P43/00 ,  C07K1/00 ,  C07K5/06 ,  C07K5/062 ,  C07K14/81 ,  C08G59/40 ,  C07K ,  A61K

CPC classification number: C08G59/40 ,  A61K9/1617 ,  A61K9/1652 ,  A61K9/2081 ,  A61K9/5047 ,  A61K38/04

公开(公告)号：PT89061A

公开(公告)日：1988-12-01

申请号：PT8906188

申请日：1988-11-23

Applicant: HOECHST AG

Inventor： FUELBERTH WERNER ,  LEEB RICHARD ,  RADAU MANFRED ,  STAMMBERGER WILLI

IPC: A61K9/16 ,  A61K9/20 ,  A61K38/00 ,  A61K9/36 ,  A61K9/50 ,  A61K38/04 ,  A61K38/55 ,  A61K47/02 ,  A61K47/30 ,  A61K47/38 ,  A61P9/12 ,  A61P43/00 ,  C07K1/00 ,  C07K5/06 ,  C07K5/062 ,  C07K14/81 ,  C08G59/40 ,  A61K37/02

Abstract: Stabilised compounds of the formula I in which R, R , R , R , R and R have the stated meanings, and process for the preparation thereof are described. The stabilised compounds are suitable for the production of pharmaceutical preparations.

公开(公告)号：CA1102242A

公开(公告)日：1981-06-02

申请号：CA304493

申请日：1978-05-31

Applicant: HOECHST AG

Inventor： SCHMITT KARL ,  HOFFMANN IRMGARD ,  FUELBERTH WERNER ,  STAMMBERGER WILLI

IPC: A61K31/47 ,  A61K31/55 ,  A61P25/24 ,  A61P25/26

Abstract: MEDICINAL COMPOSITION AND ITS USE AS ANTIDEPRESSIVE AGENT of the disclosure: Medicinal composition containing compounds of the general formula I (I) in which R1, R3 and R4, which may be identical or different, and represent hydrogen atoms or lower alkyl or aralkyl groups, and R2 and R?, which may be identical or different, represent hydrogen or halogen atoms, hydroxy or trifluoromethyl groups or lower alkyl alkoxy or aralkoxy groups, it also being possible that that two adjacent radicals form an alkylene-dioxy radical, and R5 represents a hydrogen or halogen atom, a hydroxy, trifluoromethyl or nitro group or a lower alkyl, alkoxy or aralkoxy radical, and their salts with acids (active substance A) and 7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4 (3H,5H)-dione (active substance B), and its use as antidepressive agent.

公开(公告)号：CA1338344C

公开(公告)日：1996-05-21

申请号：CA583952

申请日：1988-11-23

Applicant: HOECHST AG

Inventor： FUELBERTH WERNER ,  LEEB RICHARD ,  RADAU MANFRED ,  STAMMBERGER WILLI

IPC: A61K38/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/36 ,  A61K9/50 ,  A61K38/04 ,  A61K38/55 ,  A61K47/02 ,  A61K47/30 ,  A61K47/38 ,  A61P9/12 ,  A61P43/00 ,  C07K1/00 ,  C07K5/06 ,  C07K5/062 ,  C07K14/81 ,  C08G59/40 ,  C07K5/072 ,  A61K38/05 ,  A61K9/30

Abstract: Stabilized compounds of the formula I I in which R, R1, R2, R3, R4 and R5 have the stated meanings, and a process for the preparation thereof, are described. The stabilized compounds are suitable for the manufacture of medicinal formulations.

公开(公告)号：CA1247526A

公开(公告)日：1988-12-28

申请号：CA497412

申请日：1985-12-11

Applicant: HOECHST AG

Inventor： FUELBERTH WERNER ,  FREUER HANS-GEORG

IPC: A61K35/39 ,  A61K9/22 ,  A61K9/28 ,  A61K9/30 ,  A61K9/32 ,  A61K38/46 ,  A61K38/54 ,  C12N9/94 ,  A61K37/48

Abstract: of the disclosure A process for the preparation of pancreatic enzyme products in compressed form is described. A water-based insulating layer and a final lacquer based on organic solvents are applied to the core which contains the active compounds.

公开(公告)号：DK572985A

公开(公告)日：1986-06-13

申请号：DK572985

申请日：1985-12-11

Applicant: HOECHST AG

Inventor： FUELBERTH WERNER ,  FREUER HANS-GEORG

IPC: A61K35/39 ,  A61K9/22 ,  A61K9/28 ,  A61K9/30 ,  A61K9/32 ,  A61K38/46 ,  A61K38/54 ,  C12N9/94 ,  A61K

Abstract: A process for the preparation of pancreatic enzyme products in compressed form is described. A water-based insulating layer and a final lacquer based on organic solvents are applied to the core which contains the active compounds.

公开(公告)号：ZA821036B

公开(公告)日：1983-01-26

申请号：ZA821036

申请日：1982-02-17

Applicant: HOECHST AG

Inventor： FUELBERTH WERNER ,  SICKMUELLER ALFRED ,  STAMMBERGER WILLI

IPC: A23L1/00 ,  A23L2/60 ,  A23L27/30 ,  A23P1/02 ,  A61J3/10 ,  A61K9/46 ,  A23L

公开(公告)号：MTP762A

公开(公告)日：1974-08-07

申请号：MTP762

申请日：1974-03-13

Applicant: HOECHST AG

Inventor： NEUBAUER HORST ,  FUELBERTH WERNER

IPC: A61K9/48 ,  A61K38/46

CPC classification number: A61K35/413 ,  A61K38/465 ,  A61K38/47 ,  A61K38/48 ,  A61K38/4873 ,  A61K2300/00

公开(公告)号：DK158489C

公开(公告)日：1990-10-29

申请号：DK69782

申请日：1982-02-17

Applicant: HOECHST AG

Inventor： FUELBERTH WERNER ,  SICKMUELLER ALFRED ,  STAMMBERGER WILLI

IPC: A23L1/00 ,  A23L2/60 ,  A23L27/30 ,  A23P1/02 ,  A61J3/10 ,  A61K9/46 ,  A23L1/236

公开(公告)号：NO885213L

公开(公告)日：1989-05-25

申请号：NO885213

申请日：1988-11-23

Applicant: HOECHST AG

Inventor： FUELBERTH WERNER ,  LEEB RICHARD ,  RADAU MANFRED ,  STAMMBERGER WILLI

IPC: A61K9/16 ,  A61K38/00 ,  A61K9/20 ,  A61K9/36 ,  A61K9/50 ,  A61K38/04 ,  A61K38/55 ,  A61K47/02 ,  A61K47/30 ,  A61K47/38 ,  A61P9/12 ,  A61P43/00 ,  C07K1/00 ,  C07K5/06 ,  C07K5/062 ,  C07K14/81 ,  C08G59/40 ,  A61K

Abstract: Stabilised compounds of the formula I in which R, R , R , R , R and R have the stated meanings, and process for the preparation thereof are described. The stabilised compounds are suitable for the production of pharmaceutical preparations.