公开(公告)号：DE3161691D1

公开(公告)日：1984-01-26

申请号：DE3161691

申请日：1981-05-28

Applicant: HOECHST AG

Inventor： KONIG WOLFGANG DR ,  GEIGER ROLF DR PROF ,  SANDOW JURGEN KURT DR

IPC: A61K38/04 ,  A61K38/00 ,  A61P43/00 ,  C07K7/23 ,  C07K14/575 ,  C07C103/52 ,  A61K37/38

Abstract: What are disclosed are a nonapeptide of the formula +TR wherein D-Aad (OBut) represents D- alpha -aminoadipic acid delta -tert. butyl ester, methods for making this peptide, pharmaceutical preparations containing this peptide, and methods for its use in increasing fertility or for contraception.

公开(公告)号：GR851394B

公开(公告)日：1985-11-25

申请号：GR850101394

申请日：1985-06-07

Applicant: HOECHST AG

Inventor： KONIG WOLFGANG DR ,  GEIGER ROLF DR PROF ,  OBERMEIER RAINER DR ,  MULLNER HUBERT DR

IPC: A61K38/00 ,  A61K38/22 ,  A61P37/00 ,  C07K7/06 ,  C07K14/66

Abstract: The invention relates to a process for the preparation of peptides of the general formula Arg-Lys-S-Val-Y in which S denotes glutamic acid or alpha -aminoadipic acid and Y denotes tyrosine or tryptophan or esters or amides thereof, which comprises subjecting tetrapeptides of the formula Z-Arg(Z'2)-Lys(Z')-S-(Bzl)-Val-OH in which Z' represents a protective group of the benzyl type, to a condensation reaction with corresponding tyrosine esters or amides or tryptophan esters or amides and removing the protective groups by hydrogenation. The invention furthermore relates to tetrapeptides as intermediate products of this process.