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    7.
    发明专利
    未知

    公开(公告)号：GR82436B

    公开(公告)日：1984-12-13

    申请号：GR840175419

    申请日：1984-07-25

    Applicant: HOECHST AG

    Inventor： ENGELS JOACHIM DR ,  KOENIG WOLFGANG DR ,  MULLNER HUBERT DR ,  UHLMANN EUGEN DR ,  WETEKAM WALDEMAR DR

    IPC: C12N15/09 ,  C07H21/00 ,  C07H21/04 ,  C07K1/00 ,  C07K7/08 ,  C07K14/00 ,  C07K14/575 ,  C07K14/60 ,  C07K19/00 ,  C12N1/20 ,  C12N15/00 ,  C12N15/16 ,  C12N15/31 ,  C12P21/00 ,  C12P21/02 ,  C12R1/19

    Abstract: Polypeptides with a carboxamide carboxyl terminus and a methionine residue, which is optionally bound to a bacterial protein, at the amino end can be prepared by genetic engineering synthesis of the corresponding polypeptide with a glycine residue at the C terminus and the enzymatic conversion thereof into the amino group of the required carboxamide moiety. Peptides which have the amino-acid sequence of growth hormone releasing factor, part sequences thereof or modifications of these peptides can easily be obtained in this way. The genetic engineering synthesis is expediently carried out using two gene fragments which are chemically synthesised from single-stranded smaller fragments. The two gene fragments are then linked enzymatically to give the complete gene, incorporated in a suitable vector, amplified there, the peptide is isolated directly or as fusion protein and is converted enzymatically into the required amide.

    8.
    发明专利
    未知

    公开(公告)号：GR851394B

    公开(公告)日：1985-11-25

    申请号：GR850101394

    申请日：1985-06-07

    Applicant: HOECHST AG

    Inventor： KONIG WOLFGANG DR ,  GEIGER ROLF DR PROF ,  OBERMEIER RAINER DR ,  MULLNER HUBERT DR

    IPC: A61K38/00 ,  A61K38/22 ,  A61P37/00 ,  C07K7/06 ,  C07K14/66

    Abstract: The invention relates to a process for the preparation of peptides of the general formula Arg-Lys-S-Val-Y in which S denotes glutamic acid or alpha -aminoadipic acid and Y denotes tyrosine or tryptophan or esters or amides thereof, which comprises subjecting tetrapeptides of the formula Z-Arg(Z'2)-Lys(Z')-S-(Bzl)-Val-OH in which Z' represents a protective group of the benzyl type, to a condensation reaction with corresponding tyrosine esters or amides or tryptophan esters or amides and removing the protective groups by hydrogenation. The invention furthermore relates to tetrapeptides as intermediate products of this process.

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