公开(公告)号：CA2107008C

公开(公告)日：2004-11-16

申请号：CA2107008

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH M ,  RAJAGOPALAN RAMANUJAN ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SCHOLZ WOLFGANG

IPC: A61K31/47 ,  A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12 ,  C07D217/14 ,  C07D401/02 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  A61K31/495 ,  A61K31/535

Abstract: Antiarrhythmic and Cardioprotective Substituted -1(2H)Isoquinolines, proce ss for their production, medicament containing them and their use for the production of a medicament for combating heart failures Described are guanidinocarbonyl isoquinolines I, (see formula I) with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G (see formula VII) X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide , (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their preparation, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmi c conditions as well as cardioprotective agents in mammals.

公开(公告)号：CA2107008A1

公开(公告)日：1994-03-29

申请号：CA2107008

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH M ,  RAJAGOPALAN RAMANUJAN ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SCHOLZ WOLFGANG

IPC: A61K31/47 ,  A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12 ,  C07D217/14 ,  C07D401/02 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  A61K31/495 ,  A61K31/535

Abstract: Antiarrhythmic and Cardioprotective Substituted -1(2H)isoquinolines, process for their production, medicament containing them and their use for the production of a medicament for combating heart failures Described are guanidinocarbonyl isoquinolines I, I with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G V I I X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their preparation, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.