公开(公告)号：AT198328T

公开(公告)日：2001-01-15

申请号：AT93115081

申请日：1993-09-20

Applicant: HOECHST AG

Inventor： LAL BANSI DR ,  GIDWANI RAMESH MATIORAM DR ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN DR ,  ENGLERT HEINRICH DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/47 ,  A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：NO180374C

公开(公告)日：1997-04-09

申请号：NO933450

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SCHOLZ WOLFGANG

IPC: A61K31/472 ,  A61P9/00 ,  A61K31/47 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：AU662079B2

公开(公告)日：1995-08-17

申请号：AU4865993

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI DR ,  GIDWANI RAMESH MATIORAM DR ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN DR ,  ENGLERT HEINRICH DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/47 ,  A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：FI934185A

公开(公告)日：1994-03-29

申请号：FI934185

申请日：1993-09-24

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SCHOLZ WOLFGANG

IPC: A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61K31/47 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：CA2107008A1

公开(公告)日：1994-03-29

申请号：CA2107008

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH M ,  RAJAGOPALAN RAMANUJAN ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SCHOLZ WOLFGANG

IPC: A61K31/47 ,  A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12 ,  C07D217/14 ,  C07D401/02 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  A61K31/495 ,  A61K31/535

Abstract: Antiarrhythmic and Cardioprotective Substituted -1(2H)isoquinolines, process for their production, medicament containing them and their use for the production of a medicament for combating heart failures Described are guanidinocarbonyl isoquinolines I, I with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G V I I X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their preparation, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：GR3035537T3

公开(公告)日：2001-06-29

申请号：GR20010400378

申请日：2001-03-09

Applicant: HOECHST AG

Inventor： LAL BANSI DR ,  GIDWANI RAMESH MATIORAM DR ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN DR ,  ENGLERT HEINRICH DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/472 ,  A61P9/00 ,  A61K31/47 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：DE69329787T2

公开(公告)日：2001-06-13

申请号：DE69329787

申请日：1993-09-20

Applicant: HOECHST AG

Inventor： LAL DR ,  GIDWANI DR ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG DR ,  ENGLERT DR ,  SCHOLZ DR

IPC: A61K31/472 ,  A61P9/00 ,  A61K31/47 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：ZA937141B

公开(公告)日：1994-05-18

申请号：ZA937141

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SANKAR CHINNAKULANDAI ,  SCHOLZ WOLFGANG

IPC: A61K31/472 ,  A61P9/00 ,  A61K31/47 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12 ,  C07D ,  A61K

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：FI103884B

公开(公告)日：1999-10-15

申请号：FI934185

申请日：1993-09-24

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SCHOLZ WOLFGANG

IPC: A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61K31/47 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

公开(公告)号：NO180374B

公开(公告)日：1996-12-30

申请号：NO933450

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SCHOLZ WOLFGANG

IPC: A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61K31/47 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.