公开(公告)号：KR780000548B1

公开(公告)日：1978-11-08

申请号：KR770002722

申请日：1977-11-21

Applicant: HOECHST AG

Inventor： NAHM HELMUT DR ,  GRANZER ERNOLD DR

IPC: A61K31/19 ,  C07C37/05 ,  C07C43/263 ,  C07C43/29 ,  C07C51/09 ,  C07C59/68 ,  C07C59/70 ,  C07C69/712

公开(公告)号：KR780000549B1

公开(公告)日：1978-11-08

申请号：KR770002721

申请日：1977-11-21

Applicant: HOECHST AG

Inventor： NAHM HELMUT DR ,  GRANZER ERNOLD DR

IPC: A61K31/19 ,  C07C37/05 ,  C07C43/263 ,  C07C43/29 ,  C07C51/09 ,  C07C59/68 ,  C07C59/70 ,  C07C69/712

公开(公告)号：KR780000547B1

公开(公告)日：1978-11-08

申请号：KR720001091

申请日：1972-07-15

Applicant: HOECHST AG

Inventor： NAHM HELMUT DR ,  GRANZER ERNOLD DR

IPC: A61K31/19 ,  C07C37/05 ,  C07C43/263 ,  C07C43/29 ,  C07C51/09 ,  C07C59/68 ,  C07C59/70 ,  C07C69/712 ,  C07C59/25

公开(公告)号：JPS5820949B1

公开(公告)日：1983-04-26

申请号：JP7406472

申请日：1972-07-24

Applicant: HOECHST AG

Inventor： NAHM HELMUT DR ,  GRANZER ERNOLD DR

IPC: A61K31/19 ,  C07C37/05 ,  C07C43/263 ,  C07C43/29 ,  C07C51/09 ,  C07C59/68 ,  C07C59/70 ,  C07C69/712 ,  C07C59/125 ,  C07C51/347 ,  C07C67/30

公开(公告)号：DE59107442D1

公开(公告)日：1996-04-04

申请号：DE59107442

申请日：1991-04-03

Applicant: HOECHST AG

Inventor： BECK GERHARD DR ,  SCHACHT ULRICH DR ,  KESSELER KURT DR ,  GRANZER ERNOLD DR

IPC: A61K31/35 ,  A61K31/352 ,  A61P3/06 ,  A61P9/10 ,  A61P31/00 ,  C07D211/20 ,  C07D311/30

Abstract: Substituted 3-thia- and 3-oxa-alkylflavones of formula I I wherein R, R1, R2, R3, R4+L, X, m and n have the indicated meanings, a process for the preparation of these compounds and their use as medicaments and pharmaceutical preparations are described. In addition, new intermediates for the preparation of the compounds of formula I are described.

公开(公告)号：ES2082755T3

公开(公告)日：1996-04-01

申请号：ES88710018

申请日：1988-07-07

Applicant: HOECHST AG

Inventor： KESSELER KURT DR ,  BECK GERHARD DR ,  BARTMANN WILHELM PROF DR ,  GRANZER ERNOLD DR

IPC: A61K31/44 ,  A61K31/365 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  C07D213/55 ,  C07D239/26 ,  C07D405/06 ,  C07D405/14 ,  C07F7/18

Abstract: 3-Desmethylmevalonic acid derivatives of the formula I ( delta -lactone) or II (corresponding dihydroxycarboxylic acid derivative) … … in which A-B, Z, R , R , R and R have the meanings given, are used as medicaments.

公开(公告)号：DE4024425A1

公开(公告)日：1992-02-06

申请号：DE4024425

申请日：1990-08-01

Applicant: HOECHST AG

Inventor： GRABLEY SUSANNE DR ,  HAMMANN PETER DR ,  ROMEYKE YVONNE DIPL CHEM ,  GRANZER ERNOLD DR

IPC: C07C31/22 ,  C07C33/02 ,  C07C45/51 ,  C07C49/24 ,  C07D309/30

Abstract: Prepns. of delta lactones (I) in the 3R5R (Ia), 3R5S (Ib), 3S5S (Ic) and 3S5R (Id) configurations are new. R1 = 3-15C alkyl or alkenyl (with 1-7 C-C double bonds) or CH2OH. (I), except (Ia) where R1 = 5C alkyl are new. Also new are the precursors (IIb) and the 3S5R (IIIa), 3R5S (IIIc) and 3R5R (IIId) forms of (III). Pref. synthesis is diastereoselective redn. of the oxo gp. of cpd. (IIa) to (IIIa)/(IIIb), then regioselectively oxidising to (Ia) or (Ib).

公开(公告)号：DE2963278D1

公开(公告)日：1982-08-19

申请号：DE2963278

申请日：1979-12-05

Applicant: HOECHST AG

Inventor： KAMPE KLAUS-DIETER DR ,  GRANZER ERNOLD DR

IPC: A61K31/415 ,  A61K31/505 ,  A61P3/04 ,  A61P3/06 ,  C07D239/48 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14

Abstract: What is disclosed are 4-amino-2-ureido (or -thioureido)-pyrimidine-5-carboxylic acid anilides of the formula further defined in the specification, and physiologically acceptable acid addition salts thereof, methods for treating adiposity and disturbances of the lipometabolism with these compounds or salts, and pharmaceutical compositions containing these compounds or salts and useful for inducing anorexia or affecting the lipometabolism.

公开(公告)号：DK143271B

公开(公告)日：1981-08-03

申请号：DK364272

申请日：1972-07-21

Applicant: HOECHST AG

Inventor： NAHM HELMUT DR ,  GRANZER ERNOLD DR

IPC: A61K31/19 ,  C07C37/05 ,  C07C43/263 ,  C07C43/29 ,  C07C51/09 ,  C07C59/68 ,  C07C59/70 ,  C07C69/712 ,  C07C59/64

Abstract: Novel 4-phenoxy-phenoxy-alkane-carboxylic acid derivatives of the formula I in which R1 stands for hydrogen, methylithio, cyclopentyl, cyclohexyl, phenyl, methylcycylohexyl, ethylcyclohexyl, or R1 and R3 together stand for a -CH=CH-CH=CH- bridge or-unless at least one of the substituents R2 to R8 stands for hydrogen, or if R9 stands for a radical having at least 2 carbon atoms-for chlorine, R2 and R3, independent of one another, each stands for hydrogen, chlorine or alkyl of 1 to 4 carbon atoms, R4 stands for hydrogen, chlorine, alkyl of 1 to 4 carbon atoms, cyclopentyl, cyclohexyl, methylcyclohexyl or R3 and R4 together stand for a -CH=CH-CH=CH- bridge, R5, R6 and R7, independent of one another, each stands for hydrogen or alkyl of 1 to 4 carbon atoms, R8 stands for hydrogen, alkyl of 1 to 4 carbon atoms or allyl, R9 stands for alkyl of 1 to 10 carbon atoms or phenyl and X stands for hydrogen, the cation of a physiologically acceptable inorganic or organic base of a hydrocarbon radical of 1 to 10 carbon atoms, having a strong action on the lipide and cholesterine metabolism and a process for this manufacture.

公开(公告)号：FI55171C

公开(公告)日：1979-06-11

申请号：FI207072

申请日：1972-07-21

Applicant: HOECHST AG

Inventor： NAHM HELMUT DR ,  GRANZER ERNOLD DR

IPC: A61K31/19 ,  C07C37/05 ,  C07C43/263 ,  C07C43/29 ,  C07C51/09 ,  C07C59/68 ,  C07C59/70 ,  C07C69/712 ,  C07C59/25 ,  C07C69/76

Abstract: Novel 4-phenoxy-phenoxy-alkane-carboxylic acid derivatives of the formula I in which R1 stands for hydrogen, methylithio, cyclopentyl, cyclohexyl, phenyl, methylcycylohexyl, ethylcyclohexyl, or R1 and R3 together stand for a -CH=CH-CH=CH- bridge or-unless at least one of the substituents R2 to R8 stands for hydrogen, or if R9 stands for a radical having at least 2 carbon atoms-for chlorine, R2 and R3, independent of one another, each stands for hydrogen, chlorine or alkyl of 1 to 4 carbon atoms, R4 stands for hydrogen, chlorine, alkyl of 1 to 4 carbon atoms, cyclopentyl, cyclohexyl, methylcyclohexyl or R3 and R4 together stand for a -CH=CH-CH=CH- bridge, R5, R6 and R7, independent of one another, each stands for hydrogen or alkyl of 1 to 4 carbon atoms, R8 stands for hydrogen, alkyl of 1 to 4 carbon atoms or allyl, R9 stands for alkyl of 1 to 10 carbon atoms or phenyl and X stands for hydrogen, the cation of a physiologically acceptable inorganic or organic base of a hydrocarbon radical of 1 to 10 carbon atoms, having a strong action on the lipide and cholesterine metabolism and a process for this manufacture.