公开(公告)号：ES2054738T3

公开(公告)日：1994-08-16

申请号：ES88110834

申请日：1988-07-07

Applicant: HOECHST AG

Inventor： BERGMANN ANDREAS DR ,  BARTMANN WILHELM PROF DR ,  BECK GERHARD DR ,  LAU HANS-HERMANN DR

IPC: C07D213/30 ,  A61K31/365 ,  A61K31/366 ,  A61K31/38 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/50 ,  A61P3/06 ,  A61P9/10 ,  C07C45/68 ,  C07C47/55 ,  C07C51/00 ,  C07C51/09 ,  C07C59/00 ,  C07C59/125 ,  C07C59/48 ,  C07C59/68 ,  C07C59/72 ,  C07C59/90 ,  C07C67/00 ,  C07C313/00 ,  C07C323/52 ,  C07C333/04 ,  C07D213/55 ,  C07D239/26 ,  C07D309/10 ,  C07D309/30 ,  C07D405/06 ,  C07D405/10 ,  C07D405/12 ,  C07D407/06 ,  C07D407/12 ,  C07D409/06 ,  C07D409/12 ,  C07D493/04 ,  C07D493/14 ,  C07F7/18 ,  C07H15/18

Abstract: 3-Desmethyl-4-fluoromevalonic acid derivatives of the formula I and the corresponding dihydroxycarboxylic acid derivatives of the formula II … … in which R, X and Y have the meanings given, processes for the preparation of these compounds, their use as medicaments and pharmaceutical preparations are described. Novel intermediates for the preparation of the compounds of the formula I or formula II are additionally described.

公开(公告)号：GR3002945T3

公开(公告)日：1993-01-25

申请号：GR910401331

申请日：1991-10-18

Applicant: HOECHST AG

Inventor： WESS GUENTHER DR ,  BARTMANN WILHELM PROF DR ,  BECK GERHARD DR ,  ANAGNOSTOPULOS HIRISTO

IPC: A61K31/085 ,  A61K31/10 ,  A61K31/12 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61K31/38 ,  A61K31/22 ,  A61K31/34 ,  A61K31/381 ,  A61K31/395 ,  A61K31/41 ,  A61K31/44 ,  A61K31/535 ,  A61K31/5375 ,  A61P1/04 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07C41/00 ,  C07C43/00 ,  C07C43/178 ,  C07C43/20 ,  C07C43/235 ,  C07C43/263 ,  C07C45/00 ,  C07C47/52 ,  C07C49/84 ,  C07C51/00 ,  C07C59/125 ,  C07C65/21 ,  C07C67/00 ,  C07C69/007 ,  C07C69/025 ,  C07C69/675 ,  C07C69/92 ,  C07C201/00 ,  C07C235/06 ,  C07C235/16 ,  C07C239/00 ,  C07C239/14 ,  C07C313/00 ,  C07C317/00 ,  C07C317/04 ,  C07C317/18 ,  C07C317/22 ,  C07C317/24 ,  C07C317/44 ,  C07C317/46 ,  C07C323/00 ,  C07C323/16 ,  C07C323/19 ,  C07C323/22 ,  C07C323/52 ,  C07C323/56 ,  C07C323/60 ,  C07C323/65 ,  C07D213/30 ,  C07D257/04 ,  C07D295/18 ,  C07D317/36 ,  C07D317/38 ,  C07D333/16

Abstract: Leukotriene antagonists, a process for the preparation thereof, and the use thereof for the treatment of diseases (I) in which R1, R2, R3, R4, R5 and X have the indicated meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals, and pharmaceutical products based on these compounds, are described.

公开(公告)号：DE3632893A1

公开(公告)日：1988-04-07

申请号：DE3632893

申请日：1986-09-27

Applicant: HOECHST AG

Inventor： BARTMANN WILHELM PROF DR ,  BECK GERHARD DR ,  JENDRALLA HEINER DR ,  KEREKJARTO BELA VON DR

IPC: C07D309/10 ,  C07D309/30 ,  C07F7/18 ,  A61K31/19 ,  A61K31/365 ,  C07C155/02

Abstract: The compounds mentioned in the title, of the formula I in which R , R , R , R , R and n have the meanings indicated, and the corresponding open-chain dihydroxycarboxylic acids, their pharmacologically tolerable salts and esters, processes for the preparation of these compounds, their use as medicaments and pharmaceutical preparations are described. Novel intermediates for the preparation of the compounds of the formula I are additionally described.

公开(公告)号：ES2061779T3

公开(公告)日：1994-12-16

申请号：ES89108378

申请日：1989-05-10

Applicant: HOECHST AG

Inventor： JENDRALLA HEINER DR ,  WESS GUNTHER DR ,  BARTMANN WILHELM PROF DR ,  BECK GERHARD DR

IPC: A61K31/365 ,  A61K31/185 ,  A61K31/19 ,  A61K31/35 ,  A61K31/366 ,  A61P3/06 ,  C07C39/367 ,  C07C59/64 ,  C07C59/68 ,  C07C323/01 ,  C07C323/09 ,  C07D309/30

Abstract: Compounds of the general formula I and the corresponding open-chain dihydroxy carboxylic acids of the formula II in which X, Y and Z have the stated meanings, and their pharmacologically tolerated salts with bases and their pharmacologically tolerated esters, process for preparing this compound, its use as pharmaceutical and pharmaceutical products are described. Also described are phenols and thiophenols of the formula III in which X, Y and Z have the stated meanings.

公开(公告)号：AT99301T

公开(公告)日：1994-01-15

申请号：AT89108378

申请日：1989-05-10

Applicant: HOECHST AG

Inventor： JENDRALLA HEINER DR ,  WESS GUENTHER DR ,  BARTMANN WILHELM PROF DR ,  BECK GERHARD DR

IPC: A61K31/185 ,  A61K31/35 ,  C07C39/367 ,  C07C59/64 ,  C07C323/01 ,  C07D309/30

公开(公告)号：AT87916T

公开(公告)日：1993-04-15

申请号：AT88110834

申请日：1988-07-07

Applicant: HOECHST AG

Inventor： BERGMANN ANDREAS DR ,  BARTMANN WILHELM PROF DR ,  BECK GERHARD DR ,  LAU HANS-HERMANN DR

IPC: C07D213/30 ,  A61K31/365 ,  A61K31/366 ,  A61K31/38 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/50 ,  A61P3/06 ,  A61P9/10 ,  C07C45/68 ,  C07C47/55 ,  C07C51/00 ,  C07C51/09 ,  C07C59/00 ,  C07C59/125 ,  C07C59/48 ,  C07C59/68 ,  C07C59/72 ,  C07C59/90 ,  C07C67/00 ,  C07C313/00 ,  C07C323/52 ,  C07C333/04 ,  C07D213/55 ,  C07D239/26 ,  C07D309/10 ,  C07D309/30 ,  C07D405/06 ,  C07D405/10 ,  C07D405/12 ,  C07D407/06 ,  C07D407/12 ,  C07D409/06 ,  C07D409/12 ,  C07D493/04 ,  C07D493/14 ,  C07F7/18 ,  C07H15/18

公开(公告)号：ES2082755T3

公开(公告)日：1996-04-01

申请号：ES88710018

申请日：1988-07-07

Applicant: HOECHST AG

Inventor： KESSELER KURT DR ,  BECK GERHARD DR ,  BARTMANN WILHELM PROF DR ,  GRANZER ERNOLD DR

IPC: A61K31/44 ,  A61K31/365 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  C07D213/55 ,  C07D239/26 ,  C07D405/06 ,  C07D405/14 ,  C07F7/18

Abstract: 3-Desmethylmevalonic acid derivatives of the formula I ( delta -lactone) or II (corresponding dihydroxycarboxylic acid derivative) … … in which A-B, Z, R , R , R and R have the meanings given, are used as medicaments.

公开(公告)号：DE58906520D1

公开(公告)日：1994-02-10

申请号：DE58906520

申请日：1989-05-10

Applicant: HOECHST AG

Inventor： JENDRALLA HEINER DR ,  WESS GUENTHER DR ,  BARTMANN WILHELM PROF DR ,  BECK GERHARD DR

IPC: A61K31/365 ,  A61K31/185 ,  A61K31/19 ,  A61K31/35 ,  A61K31/366 ,  A61P3/06 ,  C07C39/367 ,  C07C59/64 ,  C07C59/68 ,  C07C323/01 ,  C07C323/09 ,  C07D309/30

Abstract: Compounds of the general formula I and the corresponding open-chain dihydroxy carboxylic acids of the formula II in which X, Y and Z have the stated meanings, and their pharmacologically tolerated salts with bases and their pharmacologically tolerated esters, process for preparing this compound, its use as pharmaceutical and pharmaceutical products are described. Also described are phenols and thiophenols of the formula III in which X, Y and Z have the stated meanings.

公开(公告)号：DE3864345D1

公开(公告)日：1991-09-26

申请号：DE3864345

申请日：1988-07-21

Applicant: HOECHST AG

Inventor： WESS GUENTHER DR ,  BARTMANN WILHELM PROF DR ,  BECK GERHARD DR ,  ANAGNOSTOPULOS HIRISTO

IPC: A61K31/38 ,  A61K31/085 ,  A61K31/10 ,  A61K31/12 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61K31/22 ,  A61K31/34 ,  A61K31/381 ,  A61K31/395 ,  A61K31/41 ,  A61K31/44 ,  A61K31/535 ,  A61K31/5375 ,  A61P1/04 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07C41/00 ,  C07C43/00 ,  C07C43/178 ,  C07C43/20 ,  C07C43/235 ,  C07C43/263 ,  C07C45/00 ,  C07C47/52 ,  C07C49/84 ,  C07C51/00 ,  C07C59/125 ,  C07C65/21 ,  C07C67/00 ,  C07C69/007 ,  C07C69/025 ,  C07C69/675 ,  C07C69/92 ,  C07C201/00 ,  C07C235/06 ,  C07C235/16 ,  C07C239/00 ,  C07C239/14 ,  C07C313/00 ,  C07C317/00 ,  C07C317/04 ,  C07C317/18 ,  C07C317/22 ,  C07C317/24 ,  C07C317/44 ,  C07C317/46 ,  C07C323/00 ,  C07C323/16 ,  C07C323/19 ,  C07C323/22 ,  C07C323/52 ,  C07C323/56 ,  C07C323/60 ,  C07C323/65 ,  C07D213/30 ,  C07D257/04 ,  C07D295/18 ,  C07D317/36 ,  C07D317/38 ,  C07D333/16

Abstract: 2-Hydroxy-3-hydroxyphenyl-propyl ether and thioether derivs. of formula (I) and their pharmaceutically acceptable salts when a COOH gp. is present, are new, where X = O, S, SO or SO2; R1 = H, 1-12C alkyl, 2-12C alkenyl or alkynyl, 3-8C cy cloalkyl or cycloalkenyl, halo, phenoxy, CF3, NO2, OH, OR6, COOH, COOR6, CHO or COR7; R2 = H, 1-12C alkyl, 2-12C alkenyl or alkynyl, 3-8C cycloalkyl or cycloalkenyl, phenyl (1-10C) alkyl, phenoxy (1-10C) alkyl, phenyl (2-10C) alkenyl, R3 = OH, OR6 or OCOR7, R4 = 1-4C alkyl (opt. su bstd. by 1-4C alkoxy or alkanoyloxy), 2-4C hydroxyalkyl, 3-4C dihydroxyalkyl, phenyl, phenyl (1-4C) alkyl (thio)phenyl rings opt. substd. by 1 or 2 OH, halo, 1-4C akloxy or alkylthio), (CH2)nCOR8 or (CH2)nR9; R5 = H, halo, CF3, OH, 1-4C aklyl or alkoxy; R6 = 1-4C alkyl, allyl or benzyl; R7 = 1-4C alkyl or phenyl; R8 = OH, 1-4C alkoxy, CH2OH, OCH2.COOH, OCH2.COOR7, oCH2Ph, NHOH, etc. R9 = tetrazol-5-yl or 2-oxo-1,3-dioxolan-4-yl; n = 0-3.

公开(公告)号：DE3816388A1

公开(公告)日：1989-11-23

申请号：DE3816388

申请日：1988-05-13

Applicant: HOECHST AG

Inventor： JENDRALLA HEINER DR ,  WESS GUENTHER DR ,  BARTMANN WILHELM PROF DR ,  BECK GERHARD DR

IPC: C07C59/68 ,  C07C323/09 ,  C07D309/30

Abstract: Novel compounds of the general formula (I) and also the corresponding open-chain dihydroxycarboxylic acids of the formula (II) in which X, Y and Z have the given meanings, and also their pharmacologically tolerated salts with bases and their pharmacologically tolerated esters, processes for the preparation of these compounds, their use as drugs (medicaments, pharmaceuticals), and also pharmaceutical preparations, are described. In addition, novel phenols and thiophenols of the formula (III) in which X, Y and Z have the given meanings, are described.e