公开(公告)号：IE921658A1

公开(公告)日：1992-12-02

申请号：IE921658

申请日：1992-07-01

Applicant: HOECHST AG

Inventor： DANIELISOVA VIERA ,  KOLVENBACH RALF ,  SCHUBERT HANS-PETER ,  GROME JOHN ,  SCHNEIDER ERNST JURGEN

IPC: A61K31/52 ,  A61K31/522 ,  A61P25/00 ,  A61P25/28 ,  C07D473/06

Abstract: The use of 1-(5-oxohexyl)-3-methyl-7-n-propylxanthine or of physiologically tolerated salts of this compound for the production of pharmaceuticals for the prophylaxis and treatment of nerve damage after interruption of the blood circulation.

公开(公告)号：PT97329A

公开(公告)日：1992-01-31

申请号：PT9732991

申请日：1991-04-11

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  ANAGNOSTOPULOS HIRISTO ,  PORSCHE-WIEBKING ELENA ,  GROME JOHN

IPC: A61K31/415 ,  A61K31/44 ,  A61K31/445 ,  A61K31/675 ,  A61P9/10 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  C07D261/04 ,  C07D261/08 ,  C07D261/12 ,  C07D261/18 ,  C07D413/04 ,  C07D413/06 ,  C07F9/653 ,  C07D261/00 ,  C07D413/00 ,  A61K31/42

Abstract: Novel 3,5-disubstituted 2-isoxazolines and isoxazoles and novel pharmaceuticals are described which are suitable, in particular, for the prophylaxis and/or treatment of pathological, neurodegenerative disorders in humans and animals. Processes for the preparation of these 3,5-disubstituted 2-isoxazolines and isoxazolines and isoxazoles are additionally indicated.

公开(公告)号：AU7428591A

公开(公告)日：1991-10-17

申请号：AU7428591

申请日：1991-04-11

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  ANAGNOSTOPULOS HIRISTO ,  PORSCHE-WIEBKING ELENA ,  GROME JOHN

IPC: A61K31/415 ,  A61K31/44 ,  A61K31/445 ,  A61K31/675 ,  A61P9/10 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  C07D261/04 ,  C07D261/08 ,  C07D261/12 ,  C07D261/18 ,  C07D413/04 ,  C07D413/06 ,  C07F9/653 ,  A61K31/42

Abstract: Novel 3,5-disubstituted 2-isoxazolines and isoxazoles and novel pharmaceuticals are described which are suitable, in particular, for the prophylaxis and/or treatment of pathological, neurodegenerative disorders in humans and animals. Processes for the preparation of these 3,5-disubstituted 2-isoxazolines and isoxazolines and isoxazoles are additionally indicated.

公开(公告)号：FI911718A

公开(公告)日：1991-10-13

申请号：FI911718

申请日：1991-04-10

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  ANAGNOSTOPULOS HIRISTO ,  PORSCHE-WIEBKING ELENA ,  GROME JOHN

IPC: A61K31/415 ,  A61K31/44 ,  A61K31/445 ,  A61K31/675 ,  A61P9/10 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  C07D261/04 ,  C07D261/08 ,  C07D261/12 ,  C07D261/18 ,  C07D413/04 ,  C07D413/06 ,  C07F9/653 ,  C07D

Abstract: Novel 3,5-disubstituted 2-isoxazolines and isoxazoles and novel pharmaceuticals are described which are suitable, in particular, for the prophylaxis and/or treatment of pathological, neurodegenerative disorders in humans and animals. Processes for the preparation of these 3,5-disubstituted 2-isoxazolines and isoxazolines and isoxazoles are additionally indicated.

公开(公告)号：CA2040219A1

公开(公告)日：1991-10-13

申请号：CA2040219

申请日：1991-04-11

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  ANAGNOSTOPULOS HIRISTO ,  PORSCHE-WIEBKING ELENA ,  GROME JOHN

IPC: A61K31/415 ,  A61K31/44 ,  A61K31/445 ,  A61K31/675 ,  A61P9/10 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  C07D261/04 ,  C07D261/08 ,  C07D261/12 ,  C07D261/18 ,  C07D413/04 ,  C07D413/06 ,  C07F9/653 ,  C07D261/00 ,  A61K31/42

Abstract: - 1 - HOE 90/F 111 of the disclosure 3,5-Disubstituted 2-isoxazolines and isoxazoles, processes for their preparation, agents containing them and their use Novel 3,5-disubstituted 2-isoxazolines and isoxazoles and novel pharmaceuticals are described which are suitable, in particular, for the prophylaxis and/or treatment of pathological, neurodegenerative disorders in humans and animals. Processes for the preparation of these 3,5disubstituted 2-isoxazolines and isoxazoles are additionally indicated.

公开(公告)号：CA2085046A1

公开(公告)日：1993-06-12

申请号：CA2085046

申请日：1992-12-10

Applicant: HOECHST AG

Inventor： KOLVENBACH RALF ,  GROME JOHN ,  SCHNEIDER ERNST J

IPC: A61K31/52 ,  A61K31/522 ,  A61P9/00 ,  C07D473/04

Abstract: HOE 91/F 384 The use of xanthine derivatives for stabilizing autoregulation of cerebral circulation. The use of at least one xanthine derivative of the formula I (I) and/or of at least one physiologically tolerable salt of the formula I in which R1 is oxoalkyl, hydroxyalkyl or alkyl, R2 is a hydrogen atom or alkyl and R3 is a hydrogen atom, alkyl, oxoalkyl or an alkyl having up to 6 carbon atoms, whose carbon chain is interrupted by an oxygen atom, for the production of pharmaceuticals for stabilizing autoregulation of cerebral circulation, and cerebral protection during cardiac or pulmonary resuscitation is described.

公开(公告)号：MX9207156A

公开(公告)日：1993-06-01

申请号：MX9207156

申请日：1992-12-10

Applicant: HOECHST AG

Inventor： KOLVENBACH ROLF ,  GROME JOHN ,  SCHNEIDER ERNST-JURGEN

IPC: A61K31/52 ,  A61K31/522 ,  A61P9/00 ,  C07D473/04

Abstract: The use of at least one xanthine derivative of the formula I, and/or of at least one physiologically tolerated salt of the formula I, where R is oxoalkyl, hydroxyalkyl or alkyl, R is hydrogen atom or alkyl and R is hydrogen atom, alkyl, oxoalkyl or an alkyl with up to 6 carbon atoms whose carbon chain is interrupted by an oxygen atom, for the preparation of pharmaceutical compositions for the stabilisation of the autoregulation of cerebral blood flow, as well as cerebral protection during cardiac or pulmonary resuscitation, is described.

公开(公告)号：HUT61469A

公开(公告)日：1993-01-28

申请号：HU9201695

申请日：1992-05-21

Applicant: HOECHST AG

Inventor： DANIELISOVA VIELA ,  KOLVENBACH RALF ,  SCHUBERT HANS-PETER ,  GROME JOHN ,  SCHNEIDER ERNST JUERGEN

IPC: A61K31/52 ,  A61K31/522 ,  A61P25/00 ,  A61P25/28 ,  C07D473/06

Abstract: The use of 1-(5-oxohexyl)-3-methyl-7-n-propylxanthine or of physiologically tolerated salts of this compound for the production of pharmaceuticals for the prophylaxis and treatment of nerve damage after interruption of the blood circulation.

公开(公告)号：CA2069202A1

公开(公告)日：1992-11-24

申请号：CA2069202

申请日：1992-05-22

Applicant: HOECHST AG

Inventor： DANIELISOVA VIERA ,  KOLVENBACH RALF ,  SCHUBERT HANS-PETER ,  GROME JOHN ,  SCHNEIDER ERNST J

IPC: A61K31/52 ,  A61K31/522 ,  A61P25/00 ,  A61P25/28 ,  C07D473/06

Abstract: of the disclosure: The use of 1-(5-oxohexyl)-3-methyl-7-n-propylxanthine in vascular surgery The use of 1-(5-oxohexyl)-3-methyl-7-n-propylxanthine or of physiologically tolerated salts of this compound for the preparation of pharmaceuticals for the prophylaxis and treatment of nerve damage after interruption of the blood circulation.

公开(公告)号：NO911432A

公开(公告)日：1991-10-14

申请号：NO911432

申请日：1991-04-11

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  ANAGNOSTOPULOS HIRISTO ,  PORSCHE-WIEBKING ELENA ,  GROME JOHN

IPC: A61K31/415 ,  A61K31/44 ,  A61K31/445 ,  A61K31/675 ,  A61P9/10 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  C07D261/04 ,  C07D261/08 ,  C07D261/12 ,  C07D261/18 ,  C07D413/04 ,  C07D413/06 ,  C07F9/653

CPC classification number: C07D413/04 ,  C07D261/04 ,  C07D261/08 ,  C07D261/18 ,  C07F9/653