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    Benzenesulfonyl-ureas and process for their preparation
    1.
    发明授权
    Benzenesulfonyl-ureas and process for their preparation 失效
    苯并呋喃及其制备方法

    公开(公告)号：US3835188A

    公开(公告)日：1974-09-10

    申请号：US37166373

    申请日：1973-06-20

    Applicant: HOECHST AG

    Inventor： WEYER R ,  HITZEL V ,  AUMULLER W ,  HEERDT R

    IPC: A61K20060101 ,  A61K31/64 ,  C07C20060101 ,  C07C127/12

    CPC classification number: Y10S514/866

    Abstract: R1 represents hydrogen, lower molecular alkyl, acyl, phenyl, R2 is hydrogen, lower molecular alkyl, R3 is alkyl having 3 to 6 carbon atoms, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkenyl, alkylcycloalkenyl having each 5 to 9 carbon atoms, cyclohexenylmethyl, chlorocyclohexyl, bicycloheptenylmethyl, bicycloheptylmethyl, bicycloheptenyl, bicycloheptyl, nortricyclyl, adamantyl, benzyl, phenylethyl, which as substance or in the form of their salts have pypoglycemic properties and which are distinguished by a strong and continuous lowering of the blood sugar level; processes for preparing them as well as pharmaceutical preparations containing the sulfonyl-ureas as an active substance.

    IN WHICH X represents hydrogen, chlorine, bromine, methoxy or methyl, Y represents -CH(CH3)-CH2-, -CH2-CH(CH3)-or preferably -CH2-CH2-, Z represents hydrogen or together with Y and the phenylene radical the radical

    Sulfonyl-ureas of the formula

    Abstract translation: 磺酰脲，其中X表示氢，氯，溴，甲氧基或甲基，Y表示-CH（CH 3）-CH 2 - ， - CH 2 -CH（CH 3） - 优选-CH 2 -CH 2 - ，Z表示氢 或与Y和亚苯基一起，基团R1代表氢，低级分子烷基，酰基，苯基，R2是氢，低级分子烷基，R3是具有3至6个碳原子的烷基，环烷基，烷基环烷基，环烷基，环烯基，烷基环烯基， 每个5至9个碳原子，环己烯基甲基，氯代环己基，双环庚烯基甲基，双环庚基甲基，双环庚烯基，双环庚基，二环己基，金刚烷基，苄基，苯乙基，其物质或其盐形式具有降血糖性质，并且通过强烈和连续降低 的血糖水平; 制备它们的方法以及含有磺酰脲类作为活性物质的药物制剂。

    Benzenesulfonyl-semicarbazides and process for their manufacture
    2.
    发明授权
    Benzenesulfonyl-semicarbazides and process for their manufacture 失效
    苯并呋喃半胱氨酸及其制备方法

    公开(公告)号：US3813398A

    公开(公告)日：1974-05-28

    申请号：US14974671

    申请日：1971-06-03

    Applicant: HOECHST AG

    Inventor： AUMUELLER W ,  WEYER R ,  HEERDT R

    IPC: A61K31/175 ,  A61K31/47 ,  A61K31/64 ,  C07D215/48 ,  C07D33/00

    CPC classification number: A61K31/47 ,  C07D215/48

    Abstract: HYPOGLYCEMICALLY ACTIIVE BENZENESULFONYL - SEMICARBAZIDES OF THE FORMULA

    1-((X-QUINOL-8-YL)-CO-NH-Y-),4-(R-NH-CO-NH-SO2-),Z-

    BENZENE

    WHEREIN X IS HYDROGEN, CHLORINE, BROMINE, METYL OR METHOXY, Y IS -CH(CH3)-CH3-, PREFERABLY

    -CH2-CH2-,

    Z IS HYDROGEN OR A HYDROCARBON RADICAL OF 1 OR 2 CARBON ATOMS, WHICH FORMS TOGETHER WITH A 5- OR 6-MEMBERED RING, R IS ALKYLENE-IMINO OF 3 TO 7 CARBON ATOMS IN THE RING WHICH MAY BE UNSATURATED OR SUBSTITUTED BY 1 OR 2 METHYL OR LOWER ALKYL OR METHOXY, PENTAMETHYLENIMINO SUBSTITUTED BY ENDOALKYLENE OF 1 TO 3 CARBON ATOMS, HEXAMETHYLENE-IMINO SUBSTITUTED BY ENDOETHYLENE IN B-EPOSITIONS, TETRAHYDRO-ISO-INDOLINE, 4,7 - ENDOALKYLENE-HEXAHYDRO- OR -TETRAHYDRO-ISO-INDOLINE, THE ENDOALKYLENE CONTAINING 1 OR 2 CARBON ATOMS AND THE DOUBLE BOND OF THE TETRAHYDRO COMPOUND BEING IN 5,6 POSITION, AND THE SALTS THEREOF.

    Benzenesulfonyl-ureas and process for their manufacture
    3.
    发明授权
    Benzenesulfonyl-ureas and process for their manufacture 失效
    苯并呋喃及其制备方法

    公开(公告)号：US3751418A

    公开(公告)日：1973-08-07

    申请号：US3751418D

    申请日：1971-06-03

    Applicant: HOECHST AG

    Inventor： WEYER R ,  AUMULLER W ,  HEERDT R ,  WEBER H ,  SCHWEITZER R

    IPC: C07D215/48 ,  C07D33/56

    CPC classification number: C07D215/48 ,  Y10S514/866

    Abstract: HYPOGLYCEMICALLY ACTIVE BENZENESULFONYL-UREAS OF THE FORMULA

    (X-QUINOLIN-8-YL)-CO-NH-Y-(2-Z-1,4-PHENYLENE)-SO2-NH-CO-

    NH-R

    WHEREIN X IS HYDROGEN, CHLORINE, BROMINE, METHOXY OR METHYL, Y IS -CH(CH3)-CH2-, -CH2-CH(CH3)OR -CH2CH2-, R IS ALKYL OF 3 TO 6 CARBON ATOMS, CYCLOALKYL OF 5 TO 8 CARBON ATOMS, WHICH MAY BE SUBSTITUTED BY 1 OR 2 ALKYL OF UP TO 3 CARBON ATOMS OR BY CHLORINE, CYCLOALKENYL OF 5 TO 8 CARBON ATOMS, WHICH MAY BE SUBSTITUTED BY 1 TO 2 ALKYL OF UP TO 3 CARBON ATOMS, BICYCLOALKYL OR BICYCLOALKENYL OF 7 OR 8 CARBON ATOMS, NORTRICYCLYL, SPIRO(2,4)-HEPTYL, Z IS HYDROGEN OR A HYDROCARBON RADICAL OF 1 OR 2 CARBON ATOMS WHICH FORMS WITH Y A 5- OR 6-MEMBERED RING, OR THE SALTS THEREOF AS WELL AS A PROCESS FOR THEIR MANUFACTURE.

    BENZENESULFONYL-UREA DERIVATIVES AND PROCESS FOR THEIR MANUFACTURE
    7.
    发明专利
    BENZENESULFONYL-UREA DERIVATIVES AND PROCESS FOR THEIR MANUFACTURE 未知

    公开(公告)号：ZA713618B

    公开(公告)日：1972-01-26

    申请号：ZA713618

    申请日：1971-06-04

    Applicant: HOECHST AG

    Inventor： WEYER R ,  SCHWEITZER R ,  HEERDT R ,  AUMUELLER W ,  WEBER H

    IPC: C07D215/48 ,  C07C ,  C07D

    Abstract: 1335913 Sulphonyl-ureas FARBWERKE HOECHST AG 7 June 1971 [6 June 1970 26 April 1971] 19306/71 Heading C2C Novel compounds (I) (including salts thereof) where X is H, Cl, Br, MeO or Me, Y is or R is C 3 to C 6 alkyl, C 5 to C 8 cycloalkyl optionally substituted by 1 or 2 alkyls of up to 3 carbon atoms in total or by Cl, C 5 to C 8 cycloalkenyl optionally substituted by 1 or 2 alkyls of up to 3 carbon atoms in total, C 7 or C 8 bicyclo-alkyl or -alkenyl, nortricyclyl, spiro[2,4]heptyl, alkylene-imino of 3 to 7 carbons in the ring which may be unsaturated and/or substituted by 1 or 2 methyls or by a C 1 to C 4 alkyl or by a MeO, pentamethylene-imino substituted by C 1 to C 3 endoalkylene, hexamethylene-imino substituted by endoethylene in #,#-position, or tetrahydroisoindoline, 4,7 - endoalkylene - hexahydro- or -tetrahydro-isoindoline the endoalkylene group containing 1 or 2 carbons and the double bond of the tetrahydro-compound being in 5,6-position, are made by standard methods. The following compounds are also prepared: N - [4 - (# - quinolino - 8 - carboxamidoethyl)- benzenesulphonyl] - N 1 - cyclohexyl - thioureaisourea methyl ether and -isothiourea methyl ether. Pharmaceutical preparations suitable for lowering the blood sugar level in the treatment of diabetes mellitus contain (I) as active ingredient; administration is orally.

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