公开(公告)号：US3850950A

公开(公告)日：1974-11-26

申请号：US36341473

申请日：1973-05-24

Applicant: HOECHST AG

Inventor： HITZEL V ,  HUBNER M ,  AUMULLER W ,  WEYER R

IPC: C07D263/56 ,  C07D85/48

CPC classification number: C07D263/56 ,  Y10S514/866

Abstract: 1. SULFONYL UREAS OF THE FORMULA

2-R1,5-X,7-(R-NH-CO-NH-SO2-(1,4-PHENYLENE)-Y-NH-CO-)-

BENZOXAZOLE

IN WHICH R1 IS HYDROGEN, METHYL, ETHYL, PHENYL, X IS HYDROGEN, CHLORINE, BROMINE OR METHYL, Y IS -CH(CH3)-CH2-, -CH2-CH(CH3)- OR, PREFERABLY, -CH2-CH2-, R IS ALKYL HAVING FROM 3 TO 6 CARBON ATOMS, CYCLOALKYL, ALKYLCYCLOALKYL, CYCLOALKYLALKYL, CYCLOALKENYL, ALKYLCYCLOALKENYL EACH HAVING FROM 5 TO 9 CARBON ATOMS, CYCLOHEXENYLMETHYL, CHLOROCYCLOHEXYL, BICYCLOHEPTENYLMETHYL, BICYCLOHEPTYLMETHYL, BICYCLOHEPTENYL, BICYCLOHEPTYL, NORTRICYCLYL, ADAMANTYL AND PHENYLALKYL HAVING FROM 1 TO 2 ALKYL CARBON ATOMS AND THE PHYSILOGICALLY TOLERABLE SALTS THEREOF.

公开(公告)号：US3816424A

公开(公告)日：1974-06-11

申请号：US22653072

申请日：1972-02-15

Applicant: HOECHST AG

Inventor： WEYER R ,  WEBER H ,  HUBNER M ,  AUMULLER W ,  SCHWEITZER R

IPC: A61K31/18 ,  A61K31/47 ,  A61K31/505 ,  C07D215/14 ,  C07D215/48 ,  C07D239/42 ,  C07D239/69 ,  C07D401/12 ,  C07D57/00

CPC classification number: C07D239/69 ,  C07D215/48 ,  Y10S514/866

Abstract: NEW SULFONAMIDOPYRIMIDINES WITH HYPOGLYCEMIC PROPERTIES HAVING THE FORMULA

1-((X-QUINOL-8-YL)-CO-NH-Y-),2-R,4-((4-R",5-R''-PYRIMIDIN-

2-YL)-NH-SO2-)BENZENE

IN WHICH X REPRESENTS HYDROGEN, CHLORINE, BROMINE, METHYL, METHOXY Y REPRESENTS -CH(CH3)-CH2-, OR, PREFERABLY,

-CH2-CH2-

R REPRESENTS HYDROGEN OR, TOGETHER WITH Y, A BRIDGE OF 3 OR 4 CARBON ATOMS, R'' REPRESENTS ALKYL, CYCLOALKYL, CYCLOALKYLALKYL, ARYL, ARALKYL, ALKOXY, CYCLOALKOXY, ALKOXYALKYL, ALKOXYALKOXY, ALKYLMERCAPTO, ALKYLMERCAPTOALKYL, THE ALKLY CONTAINING, IN ANY CASE FROM 1 TO 4 CARBON ATOMS AND THE CYCLOALKYL, IN ANY CASE, 5 TO 8 CARBON ATOMS, R" REPRESENTS HYDROGEN, LOWER ALKYL, R" AND R'' TOGETHER BEING ABLE TO FORM A RING OF FROM 3 TO 5 METHYL GROUPS, AND PHYSIOLOGICALLY TOLERABLE SALTS THEREOF AND PROCESSES FOR THEIR PREPARATION.

公开(公告)号：SE381048B

公开(公告)日：1975-11-24

申请号：SE7307384

申请日：1973-05-25

Applicant: HOECHST AG

Inventor： AUMULLER W ,  WEYER R ,  HITZEL V ,  HUBNER M

IPC: C07D263/56

公开(公告)号：SE385886B

公开(公告)日：1976-07-26

申请号：SE187472

申请日：1972-02-16

Applicant: HOECHST AG

Inventor： WEYER R ,  AUMULLER W ,  SCHWEITZER R ,  WEBER H ,  HUBNER M

IPC: A61K31/18 ,  A61K31/47 ,  A61K31/505 ,  C07D215/14 ,  C07D215/48 ,  C07D239/42 ,  C07D239/69 ,  C07D401/12 ,  C07D239/44

Abstract: 1377793 Benzenesulphonamido-pyrimidines FARBWERKE HOECHST AG 17 Feb 1972 [17 Feb 1971] 7398/72 Heading C2C Novel compounds (I) (including salts thereof) where X is H, Cl, Br, Me or MeO, Y signifies -CHMeCH 2 - or -CH 2 -CH 2 -; R is H or together with Y is a 3 or 4 C bridge, R 1 is alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, alkoxy, cycloalkoxy, alkoxyalkyl, alkoxyalkoxy, alkylmercapto or alkylmercaptoalkyl, R 11 is H or alkyl and R 1 and R 11 together represent C 3 to C 5 alkylene, are made by standard methods. The preparations of 4-(#-quinoline-8-carboxamido - ethyl) - benzenesulphochloride and of compounds VIII are also described. Pharmaceutical preparations showing hypoglycemic action contain (I) as active ingredient; administration is, e.g. orally.