公开(公告)号：DK0584694T3

公开(公告)日：1998-09-14

申请号：DK93113143

申请日：1993-08-17

Applicant: HOECHST AG

Inventor： ZOLLER GERHARD DR ,  JABLONKA BERND DR ,  JUST MELITTA DR ,  KLINGLER OTMAR DR ,  BREIPOHL GERHARD DR ,  KNOLLE JOCHEN DR ,  KOENIG WOLFGANG DR

IPC: A61K31/415 ,  A61K31/4166 ,  A61K38/00 ,  A61K38/05 ,  A61K38/07 ,  A61P7/02 ,  A61P19/10 ,  A61P35/00 ,  A61P35/04 ,  C07D233/72 ,  C07D233/76 ,  C07D233/78 ,  C07D233/86 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/072 ,  C07K5/10 ,  C07K5/117 ,  C07K5/08 ,  A61K37/02 ,  C07K15/00

Abstract: The present invention relates to compounds of the general formula I in which R, R to R and r, Y, Z and W are defined as stated in the description, to processes for their preparation and to their use as inhibitors of platelet aggregation, of metastasis of carcinoma cells, and of osteoclast binding to bone surfaces.

公开(公告)号：AT168116T

公开(公告)日：1998-07-15

申请号：AT93110754

申请日：1993-07-06

Applicant: HOECHST AG

Inventor： ZOLLER GERHARD DR ,  JABLONKA BERND DR ,  JUST MELITTA DR ,  KLINGLER OTMAR DR ,  BREIPOHL GERHARD DR ,  KNOLLE JOCHEN DR ,  KOENIG WOLFGANG DR

IPC: A61K31/415 ,  A61K31/4166 ,  A61K38/00 ,  A61K38/04 ,  A61K38/05 ,  A61P7/02 ,  A61P19/10 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D233/40 ,  C07D233/42 ,  C07D233/72 ,  C07D233/76 ,  C07D233/78 ,  C07D233/80 ,  C07D233/86 ,  C07K5/06 ,  C07K5/072 ,  C07K5/08 ,  C07K5/10 ,  C07K5/117

Abstract: Phenylimidazolidine derivatives of the general formula I in which, for example, Y is -CH2-CH2-CO- r is 0 to 3 Z is oxygen W is hydroxyl R is -NH-C(=NH)-NH2 R, R , R are hydrogen R is -CO-NHR where -NH-R is an alpha -amino acid residue, have valuable pharmacological properties.

公开(公告)号：DK0530505T3

公开(公告)日：1996-02-12

申请号：DK92113086

申请日：1992-07-31

Applicant: HOECHST AG

Inventor： KOENIG WOLFGANG DR ,  ZOLLER GERHARD DR ,  JUST MELITTTA DR ,  JABLONKA BERND DR

IPC: A61K31/415 ,  A61K31/4166 ,  A61K38/00 ,  A61K38/04 ,  A61K38/05 ,  A61K38/06 ,  A61P7/02 ,  A61P9/10 ,  A61P19/10 ,  A61P35/00 ,  A61P43/00 ,  C07D233/76 ,  C07D233/96 ,  C07K1/02 ,  C07K5/02 ,  C07K5/023 ,  C07K5/06 ,  C07K5/062 ,  C07K5/072 ,  C07K5/078 ,  C07K5/08 ,  C07K5/083 ,  C07K5/09 ,  C07K5/097 ,  C07K5/10 ,  C07K5/11 ,  C07K5/117 ,  A61K37/02

Abstract: The present invention relates to hydantoin derivatives of the general formula I in which Y and R to R are defined as indicated in claim 1, process for the preparation thereof and the use thereof for inhibiting platelet aggregation.

公开(公告)号：ES2082026T3

公开(公告)日：1996-03-16

申请号：ES91104195

申请日：1991-03-19

Applicant: HOECHST AG

Inventor： KONIG WOLFGANG DR ,  JUST MELITTA DR ,  JABLONKA BERND DR

IPC: A61K31/415 ,  A61K31/4166 ,  A61K38/00 ,  A61K38/04 ,  A61P7/02 ,  A61P19/10 ,  C07D233/72 ,  C07D233/76 ,  C07K5/08 ,  C07K5/097 ,  C07K5/10 ,  C07K5/117 ,  C07K7/02 ,  C07K7/06 ,  C07K14/78

Abstract: Hydantoin derivatives of the general formula I in which n is 3 or 4, R is alkyl or a radical of the formula with R' and R'' being hydrogen or alkyl and R is hydrogen, -NH-CO-NH2 and optionally substituted alkyl, and processes for the preparation thereof and the use thereof for inhibiting platelet aggregation are described.

公开(公告)号：DE59106881D1

公开(公告)日：1995-12-21

申请号：DE59106881

申请日：1991-03-19

Applicant: HOECHST AG

Inventor： KOENIG WOLFGANG DR ,  JUST MELITTA DR ,  JABLONKA BERND DR

IPC: A61K31/415 ,  A61K31/4166 ,  A61K38/00 ,  A61K38/04 ,  A61P7/02 ,  A61P19/10 ,  C07D233/72 ,  C07D233/76 ,  C07K5/08 ,  C07K5/097 ,  C07K5/10 ,  C07K5/117 ,  C07K7/02 ,  C07K7/06 ,  C07K14/78

Abstract: Hydantoin derivatives of the general formula I in which n is 3 or 4, R is alkyl or a radical of the formula with R' and R'' being hydrogen or alkyl and R is hydrogen, -NH-CO-NH2 and optionally substituted alkyl, and processes for the preparation thereof and the use thereof for inhibiting platelet aggregation are described.

公开(公告)号：DE4009506A1

公开(公告)日：1991-09-26

申请号：DE4009506

申请日：1990-03-24

Applicant: HOECHST AG

Inventor： KOENIG WOLFGANG DR ,  JUST MELITTA DR ,  JABLONKA BERND DR

IPC: A61K31/415 ,  A61K31/4166 ,  A61K38/00 ,  A61K38/04 ,  A61P7/02 ,  A61P19/10 ,  C07D233/72 ,  C07D233/76 ,  C07K5/08 ,  C07K5/097 ,  C07K5/10 ,  C07K5/117 ,  C07K7/02 ,  C07K7/06 ,  C07K14/78

Abstract: Hydantoin derivatives of the general formula I in which n is 3 or 4, R is alkyl or a radical of the formula with R' and R'' being hydrogen or alkyl and R is hydrogen, -NH-CO-NH2 and optionally substituted alkyl, and processes for the preparation thereof and the use thereof for inhibiting platelet aggregation are described.

公开(公告)号：ES2194842T3

公开(公告)日：2003-12-01

申请号：ES93105575

申请日：1993-04-03

Applicant: HOECHST AG

Inventor： ZOLLER GERHARD DR ,  JUST MELITTA DR ,  JABLONKA BERND DR ,  KONIG WOLFGANG DR ,  KNOLLE JOCHEN DR

IPC: A61K31/415 ,  A61K31/4166 ,  A61K31/42 ,  A61K31/425 ,  A61K38/00 ,  A61K38/04 ,  A61K38/06 ,  A61P7/02 ,  A61P19/10 ,  A61P35/00 ,  A61P43/00 ,  C07D233/72 ,  C07D233/76 ,  C07D233/80 ,  C07D233/96 ,  C07D403/12 ,  C07K5/08 ,  C07K5/10 ,  C07K5/117 ,  C08K5/08

Abstract: The present invention relates to 2,4-dioxoimidazolidine derivatives of the general formula I in which R to R and Y are defined as indicated in the description, processes for their preparation and their use as inhibitors of platelet aggregation, the metastasis of carcinoma cells and osteoclast binding to the bone surfaces.

公开(公告)号：DE59308732D1

公开(公告)日：1998-08-13

申请号：DE59308732

申请日：1993-07-06

Applicant: HOECHST AG

Inventor： ZOLLER GERHARD DR ,  JABLONKA BERND DR ,  JUST MELITTA DR ,  KLINGLER OTMAR DR ,  BREIPOHL GERHARD DR ,  KNOLLE JOCHEN DR ,  KOENIG WOLFGANG DR

IPC: A61K31/415 ,  A61K31/4166 ,  A61K38/00 ,  A61K38/04 ,  A61K38/05 ,  A61P7/02 ,  A61P19/10 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D233/40 ,  C07D233/42 ,  C07D233/72 ,  C07D233/76 ,  C07D233/78 ,  C07D233/80 ,  C07D233/86 ,  C07K5/06 ,  C07K5/072 ,  C07K5/08 ,  C07K5/10 ,  C07K5/117

Abstract: Phenylimidazolidine derivatives of the general formula I in which, for example, Y is -CH2-CH2-CO- r is 0 to 3 Z is oxygen W is hydroxyl R is -NH-C(=NH)-NH2 R, R , R are hydrogen R is -CO-NHR where -NH-R is an alpha -amino acid residue, have valuable pharmacological properties.

公开(公告)号：DE59308021D1

公开(公告)日：1998-02-26

申请号：DE59308021

申请日：1993-08-17

Applicant: HOECHST AG

Inventor： ZOLLER GERHARD DR ,  JABLONKA BERND DR ,  JUST MELITTA DR ,  KLINGLER OTMAR DR ,  BREIPOHL GERHARD DR ,  KNOLLE JOCHEN DR ,  KOENIG WOLFGANG DR

IPC: A61K31/415 ,  A61K31/4166 ,  A61K38/00 ,  A61K38/05 ,  A61K38/07 ,  A61P7/02 ,  A61P19/10 ,  A61P35/00 ,  A61P35/04 ,  C07D233/72 ,  C07D233/76 ,  C07D233/78 ,  C07D233/86 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/072 ,  C07K5/10 ,  C07K5/117

Abstract: The present invention relates to compounds of the general formula I in which R, R to R and r, Y, Z and W are defined as stated in the description, to processes for their preparation and to their use as inhibitors of platelet aggregation, of metastasis of carcinoma cells, and of osteoclast binding to bone surfaces.

公开(公告)号：ES2081000T3

公开(公告)日：1996-02-16

申请号：ES92113086

申请日：1992-07-31

Applicant: HOECHST AG

Inventor： KONIG WOLFGANG DR ,  ZOLLER GERHARD DR ,  JUST MELITTTA DR ,  JABLONKA BERND DR

IPC: A61K31/415 ,  A61K31/4166 ,  A61K38/00 ,  A61K38/04 ,  A61K38/05 ,  A61K38/06 ,  A61P7/02 ,  A61P9/10 ,  A61P19/10 ,  A61P35/00 ,  A61P43/00 ,  C07D233/76 ,  C07D233/96 ,  C07K1/02 ,  C07K5/02 ,  C07K5/023 ,  C07K5/06 ,  C07K5/062 ,  C07K5/072 ,  C07K5/078 ,  C07K5/08 ,  C07K5/083 ,  C07K5/09 ,  C07K5/097 ,  C07K5/10 ,  C07K5/11 ,  C07K5/117

Abstract: The present invention relates to hydantoin derivatives of the general formula I in which Y and R to R are defined as indicated in claim 1, process for the preparation thereof and the use thereof for inhibiting platelet aggregation.