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公开(公告)号：DK0580008T3
公开(公告)日：1999-02-08
申请号：DK93110754
申请日：1993-07-06
Applicant: HOECHST AG
Inventor： ZOLLER GERHARD DR , JABLONKA BERND DR , JUST MELITTA DR , KLINGLER OTMAR DR , BREIPOHL GERHARD DR , KNOLLE JOCHEN DR , KOENIG WOLFGANG DR
IPC: A61K31/415 , A61K31/4166 , A61K38/00 , A61K38/04 , A61K38/05 , A61P7/02 , A61P19/10 , A61P35/00 , A61P35/04 , A61P43/00 , C07D233/40 , C07D233/42 , C07D233/72 , C07D233/76 , C07D233/78 , C07D233/80 , C07D233/86 , C07K5/06 , C07K5/072 , C07K5/08 , C07K5/10 , C07K5/117 , A61K37/02
Abstract: Phenylimidazolidine derivatives of the general formula I in which, for example, Y is -CH2-CH2-CO- r is 0 to 3 Z is oxygen W is hydroxyl R is -NH-C(=NH)-NH2 R, R , R are hydrogen R is -CO-NHR where -NH-R is an alpha -amino acid residue, have valuable pharmacological properties.
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公开(公告)号：AT162531T
公开(公告)日：1998-02-15
申请号：AT93113143
申请日：1993-08-17
Applicant: HOECHST AG
Inventor： ZOLLER GERHARD DR , JABLONKA BERND DR , JUST MELITTA DR , KLINGLER OTMAR DR , BREIPOHL GERHARD DR , KNOLLE JOCHEN DR , KOENIG WOLFGANG DR
IPC: A61K31/415 , A61K31/4166 , A61K38/00 , A61K38/05 , A61K38/07 , A61P7/02 , A61P19/10 , A61P35/00 , A61P35/04 , C07D233/72 , C07D233/76 , C07D233/78 , C07D233/86 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/072 , C07K5/10 , C07K5/117
Abstract: The present invention relates to compounds of the general formula I in which R, R to R and r, Y, Z and W are defined as stated in the description, to processes for their preparation and to their use as inhibitors of platelet aggregation, of metastasis of carcinoma cells, and of osteoclast binding to bone surfaces.
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公开(公告)号：DK0584694T3
公开(公告)日：1998-09-14
申请号：DK93113143
申请日：1993-08-17
Applicant: HOECHST AG
Inventor： ZOLLER GERHARD DR , JABLONKA BERND DR , JUST MELITTA DR , KLINGLER OTMAR DR , BREIPOHL GERHARD DR , KNOLLE JOCHEN DR , KOENIG WOLFGANG DR
IPC: A61K31/415 , A61K31/4166 , A61K38/00 , A61K38/05 , A61K38/07 , A61P7/02 , A61P19/10 , A61P35/00 , A61P35/04 , C07D233/72 , C07D233/76 , C07D233/78 , C07D233/86 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/072 , C07K5/10 , C07K5/117 , C07K5/08 , A61K37/02 , C07K15/00
Abstract: The present invention relates to compounds of the general formula I in which R, R to R and r, Y, Z and W are defined as stated in the description, to processes for their preparation and to their use as inhibitors of platelet aggregation, of metastasis of carcinoma cells, and of osteoclast binding to bone surfaces.
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公开(公告)号：AT168116T
公开(公告)日：1998-07-15
申请号：AT93110754
申请日：1993-07-06
Applicant: HOECHST AG
Inventor： ZOLLER GERHARD DR , JABLONKA BERND DR , JUST MELITTA DR , KLINGLER OTMAR DR , BREIPOHL GERHARD DR , KNOLLE JOCHEN DR , KOENIG WOLFGANG DR
IPC: A61K31/415 , A61K31/4166 , A61K38/00 , A61K38/04 , A61K38/05 , A61P7/02 , A61P19/10 , A61P35/00 , A61P35/04 , A61P43/00 , C07D233/40 , C07D233/42 , C07D233/72 , C07D233/76 , C07D233/78 , C07D233/80 , C07D233/86 , C07K5/06 , C07K5/072 , C07K5/08 , C07K5/10 , C07K5/117
Abstract: Phenylimidazolidine derivatives of the general formula I in which, for example, Y is -CH2-CH2-CO- r is 0 to 3 Z is oxygen W is hydroxyl R is -NH-C(=NH)-NH2 R, R , R are hydrogen R is -CO-NHR where -NH-R is an alpha -amino acid residue, have valuable pharmacological properties.
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公开(公告)号：DK0530505T3
公开(公告)日：1996-02-12
申请号：DK92113086
申请日：1992-07-31
Applicant: HOECHST AG
Inventor： KOENIG WOLFGANG DR , ZOLLER GERHARD DR , JUST MELITTTA DR , JABLONKA BERND DR
IPC: A61K31/415 , A61K31/4166 , A61K38/00 , A61K38/04 , A61K38/05 , A61K38/06 , A61P7/02 , A61P9/10 , A61P19/10 , A61P35/00 , A61P43/00 , C07D233/76 , C07D233/96 , C07K1/02 , C07K5/02 , C07K5/023 , C07K5/06 , C07K5/062 , C07K5/072 , C07K5/078 , C07K5/08 , C07K5/083 , C07K5/09 , C07K5/097 , C07K5/10 , C07K5/11 , C07K5/117 , A61K37/02
Abstract: The present invention relates to hydantoin derivatives of the general formula I in which Y and R to R are defined as indicated in claim 1, process for the preparation thereof and the use thereof for inhibiting platelet aggregation.
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Patent Agency Ranking
公开(公告)号：AT236886T
公开(公告)日：2003-04-15
申请号：AT93105575
申请日：1993-04-03
Applicant: HOECHST AG
Inventor： ZOLLER GERHARD DR , JUST MELITTA DR , JABLONKA BERND DR , KOENIG WOLFGANG DR , KNOLLE JOCHEN DR
IPC: A61K31/415 , A61K31/4166 , A61K31/42 , A61K31/425 , A61K38/00 , A61K38/04 , A61K38/06 , A61P7/02 , A61P19/10 , A61P35/00 , A61P43/00 , C07D233/72 , C07D233/76 , C07D233/80 , C07D233/96 , C07D403/12 , C07K5/08 , C07K5/10 , C07K5/117 , C08K5/08
Abstract: The present invention relates to 2,4-dioxoimidazolidine derivatives of the general formula I in which R to R and Y are defined as indicated in the description, processes for their preparation and their use as inhibitors of platelet aggregation, the metastasis of carcinoma cells and osteoclast binding to the bone surfaces.
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公开(公告)号：ES2119837T3
公开(公告)日：1998-10-16
申请号：ES93110754
申请日：1993-07-06
Applicant: HOECHST AG
Inventor： ZOLLER GERHARD DR , JABLONKA BERND DR , JUST MELITTA DR , KLINGLER OTMAR DR , BREIPOHL GERHARD DR , KNOLLE JOCHEN DR
IPC: A61K31/415 , A61K31/4166 , A61K38/00 , A61K38/04 , A61K38/05 , A61P7/02 , A61P19/10 , A61P35/00 , A61P35/04 , A61P43/00 , C07D233/40 , C07D233/42 , C07D233/72 , C07D233/76 , C07D233/78 , C07D233/80 , C07D233/86 , C07K5/06 , C07K5/072 , C07K5/08 , C07K5/10 , C07K5/117
Abstract: Phenylimidazolidine derivatives of the general formula I in which, for example, Y is -CH2-CH2-CO- r is 0 to 3 Z is oxygen W is hydroxyl R is -NH-C(=NH)-NH2 R, R , R are hydrogen R is -CO-NHR where -NH-R is an alpha -amino acid residue, have valuable pharmacological properties.
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公开(公告)号：ES2112361T3
公开(公告)日：1998-04-01
申请号：ES93113143
申请日：1993-08-17
Applicant: HOECHST AG
Inventor： ZOLLER GERHARD DR , JABLONKA BERND DR , JUST MELITTA DR , KLINGLER OTMAR DR , BREIPOHL GERHARD DR , KNOLLE JOCHEN DR
IPC: A61K31/415 , A61K31/4166 , A61K38/00 , A61K38/05 , A61K38/07 , A61P7/02 , A61P19/10 , A61P35/00 , A61P35/04 , C07D233/72 , C07D233/76 , C07D233/78 , C07D233/86 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/072 , C07K5/10 , C07K5/117
Abstract: The present invention relates to compounds of the general formula I in which R, R to R and r, Y, Z and W are defined as stated in the description, to processes for their preparation and to their use as inhibitors of platelet aggregation, of metastasis of carcinoma cells, and of osteoclast binding to bone surfaces.
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公开(公告)号：ES2194842T3
公开(公告)日：2003-12-01
申请号：ES93105575
申请日：1993-04-03
Applicant: HOECHST AG
Inventor： ZOLLER GERHARD DR , JUST MELITTA DR , JABLONKA BERND DR , KONIG WOLFGANG DR , KNOLLE JOCHEN DR
IPC: A61K31/415 , A61K31/4166 , A61K31/42 , A61K31/425 , A61K38/00 , A61K38/04 , A61K38/06 , A61P7/02 , A61P19/10 , A61P35/00 , A61P43/00 , C07D233/72 , C07D233/76 , C07D233/80 , C07D233/96 , C07D403/12 , C07K5/08 , C07K5/10 , C07K5/117 , C08K5/08
Abstract: The present invention relates to 2,4-dioxoimidazolidine derivatives of the general formula I in which R to R and Y are defined as indicated in the description, processes for their preparation and their use as inhibitors of platelet aggregation, the metastasis of carcinoma cells and osteoclast binding to the bone surfaces.
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公开(公告)号：DE59308732D1
公开(公告)日：1998-08-13
申请号：DE59308732
申请日：1993-07-06
Applicant: HOECHST AG
Inventor： ZOLLER GERHARD DR , JABLONKA BERND DR , JUST MELITTA DR , KLINGLER OTMAR DR , BREIPOHL GERHARD DR , KNOLLE JOCHEN DR , KOENIG WOLFGANG DR
IPC: A61K31/415 , A61K31/4166 , A61K38/00 , A61K38/04 , A61K38/05 , A61P7/02 , A61P19/10 , A61P35/00 , A61P35/04 , A61P43/00 , C07D233/40 , C07D233/42 , C07D233/72 , C07D233/76 , C07D233/78 , C07D233/80 , C07D233/86 , C07K5/06 , C07K5/072 , C07K5/08 , C07K5/10 , C07K5/117
Abstract: Phenylimidazolidine derivatives of the general formula I in which, for example, Y is -CH2-CH2-CO- r is 0 to 3 Z is oxygen W is hydroxyl R is -NH-C(=NH)-NH2 R, R , R are hydrogen R is -CO-NHR where -NH-R is an alpha -amino acid residue, have valuable pharmacological properties.
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