公开(公告)号：NO753806A

公开(公告)日：1976-06-09

申请号：NO753806

申请日：1975-11-13

Applicant: HOECHST AG

Inventor： MOHLER W ,  JAYME M ,  KOMAREK J

IPC: A61K31/52 ,  C07D473/06 ,  C07D

CPC classification number: C07D473/06

公开(公告)号：SE7513759A

公开(公告)日：1976-06-08

申请号：SE7513759

申请日：1975-12-05

Applicant: HOECHST AG

Inventor： MOHLER W ,  JAYME M ,  KOMAREK J

IPC: A61K31/52 ,  C07D473/06 ,  C07D473/04

CPC classification number: C07D473/06

公开(公告)号：DK145676B

公开(公告)日：1983-01-24

申请号：DK321574

申请日：1974-06-14

Applicant: HOECHST AG

Inventor： MOHLER W ,  JAYME M ,  KOMAREK J

IPC: A61K31/52 ,  A61K31/522 ,  A61P7/02 ,  A61P9/08 ,  C07D473/06 ,  C07D473/04

Abstract: Compounds of general formula (I) wherein one of the groups R1 and R3 is a straight-chain or branched oxoalkyl group consisting from 5 to 8 carbon atoms and the oxygen atom is attached to a non-terminal carbon atom and is separated from the nearest ring nitrogen atom by at least 3 carbon atoms in ( omega -1)-oxoalkyl groups and by at least 4 carbon atoms in oxoalkyl groups in which the oxygen atom is separated from the terminal carbon atom by more than one carbon atom, R2 and the other one of groups R1 and R3 are straight chain or branched alkyl groups containing from 1 to 12 carbon atoms but wherein that group R1 or R3 which is other than an oxoalkyl group may also be hydrogen, one nitrogen-bound substituent being hydrogen or alkyl containing more than 1 carbon atom, and physiologically acceptable acid addition salts thereof, a process for their preparation and pharmaceutical compositions containing said compounds.

公开(公告)号：SE423631B

公开(公告)日：1982-05-17

申请号：SE7407913

申请日：1974-06-14

Applicant: HOECHST AG

Inventor： MOHLER W ,  JAYME M ,  KOMAREK J

IPC: A61K31/52 ,  A61K31/522 ,  A61P7/02 ,  A61P9/08 ,  C07D473/06

Abstract: Compounds of general formula (I) wherein one of the groups R1 and R3 is a straight-chain or branched oxoalkyl group consisting from 5 to 8 carbon atoms and the oxygen atom is attached to a non-terminal carbon atom and is separated from the nearest ring nitrogen atom by at least 3 carbon atoms in ( omega -1)-oxoalkyl groups and by at least 4 carbon atoms in oxoalkyl groups in which the oxygen atom is separated from the terminal carbon atom by more than one carbon atom, R2 and the other one of groups R1 and R3 are straight chain or branched alkyl groups containing from 1 to 12 carbon atoms but wherein that group R1 or R3 which is other than an oxoalkyl group may also be hydrogen, one nitrogen-bound substituent being hydrogen or alkyl containing more than 1 carbon atom, and physiologically acceptable acid addition salts thereof, a process for their preparation and pharmaceutical compositions containing said compounds.

公开(公告)号：DK321574A

公开(公告)日：1975-02-10

申请号：DK321574

申请日：1974-06-14

Applicant: HOECHST AG

Inventor： MOHLER W ,  JAYME M ,  KOMAREK J

IPC: A61K31/52 ,  A61K31/522 ,  A61P7/02 ,  A61P9/08 ,  C07D473/06 ,  C07D

Abstract: Compounds of general formula (I) wherein one of the groups R1 and R3 is a straight-chain or branched oxoalkyl group consisting from 5 to 8 carbon atoms and the oxygen atom is attached to a non-terminal carbon atom and is separated from the nearest ring nitrogen atom by at least 3 carbon atoms in ( omega -1)-oxoalkyl groups and by at least 4 carbon atoms in oxoalkyl groups in which the oxygen atom is separated from the terminal carbon atom by more than one carbon atom, R2 and the other one of groups R1 and R3 are straight chain or branched alkyl groups containing from 1 to 12 carbon atoms but wherein that group R1 or R3 which is other than an oxoalkyl group may also be hydrogen, one nitrogen-bound substituent being hydrogen or alkyl containing more than 1 carbon atom, and physiologically acceptable acid addition salts thereof, a process for their preparation and pharmaceutical compositions containing said compounds.

公开(公告)号：FI206574A

公开(公告)日：1975-01-12

申请号：FI206574

申请日：1974-07-05

Applicant: HOECHST AG

Inventor： MOHLER W ,  JAYME M ,  HINZE H-J ,  KOMAREK J ,  REISER M ,  SOEDER A

IPC: C07D473/06 ,  C07D473/08 ,  C07D473/10 ,  C07D

公开(公告)号：ZA743760B

公开(公告)日：1975-06-25

申请号：ZA743760

申请日：1974-06-12

Applicant: HOECHST AG

Inventor： JAYME M ,  MOHLER W ,  KOMAREK J

IPC: A61K31/52 ,  A61K31/522 ,  A61P7/02 ,  A61P9/08 ,  C07D473/06 ,  C07D57/40

Abstract: Compounds of general formula (I) wherein one of the groups R1 and R3 is a straight-chain or branched oxoalkyl group consisting from 5 to 8 carbon atoms and the oxygen atom is attached to a non-terminal carbon atom and is separated from the nearest ring nitrogen atom by at least 3 carbon atoms in ( omega -1)-oxoalkyl groups and by at least 4 carbon atoms in oxoalkyl groups in which the oxygen atom is separated from the terminal carbon atom by more than one carbon atom, R2 and the other one of groups R1 and R3 are straight chain or branched alkyl groups containing from 1 to 12 carbon atoms but wherein that group R1 or R3 which is other than an oxoalkyl group may also be hydrogen, one nitrogen-bound substituent being hydrogen or alkyl containing more than 1 carbon atom, and physiologically acceptable acid addition salts thereof, a process for their preparation and pharmaceutical compositions containing said compounds.

公开(公告)号：NO742464L

公开(公告)日：1975-02-10

申请号：NO742464

申请日：1974-07-05

Applicant: HOECHST AG

Inventor： MOHLER W ,  JAYME M ,  HINZE H-J ,  KOMAREK J ,  REISER M ,  SOEDER A

IPC: C07D473/06 ,  C07D473/08 ,  C07D473/10 ,  C07D

公开(公告)号：SE7310986L

公开(公告)日：1975-01-13

申请号：SE7310986

申请日：1973-08-10

Applicant: HOECHST AG

Inventor： HINZE H-J ,  SODER A ,  POPENDIKER K ,  MOHLER W ,  JAYME M ,  KOMAREK J ,  REISER M

IPC: C07D473/06 ,  C07D473/08 ,  C07D473/10 ,  C07D57/40 ,  C07D473/04

公开(公告)号：NO742121L

公开(公告)日：1975-01-13

申请号：NO742121

申请日：1974-06-11

Applicant: HOECHST AG

Inventor： MOHLER W ,  JAYME M ,  KOMAREK J

IPC: A61K31/52 ,  A61K31/522 ,  A61P7/02 ,  A61P9/08 ,  C07D473/06 ,  C07D

Abstract: Compounds of general formula (I) wherein one of the groups R1 and R3 is a straight-chain or branched oxoalkyl group consisting from 5 to 8 carbon atoms and the oxygen atom is attached to a non-terminal carbon atom and is separated from the nearest ring nitrogen atom by at least 3 carbon atoms in ( omega -1)-oxoalkyl groups and by at least 4 carbon atoms in oxoalkyl groups in which the oxygen atom is separated from the terminal carbon atom by more than one carbon atom, R2 and the other one of groups R1 and R3 are straight chain or branched alkyl groups containing from 1 to 12 carbon atoms but wherein that group R1 or R3 which is other than an oxoalkyl group may also be hydrogen, one nitrogen-bound substituent being hydrogen or alkyl containing more than 1 carbon atom, and physiologically acceptable acid addition salts thereof, a process for their preparation and pharmaceutical compositions containing said compounds.