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    PROCESS FOR THE PREPARATION OF ALKYLATED HYDROXYLAMINES
    1.
    发明授权
    PROCESS FOR THE PREPARATION OF ALKYLATED HYDROXYLAMINES 失效

    公开(公告)号：KR820000600B1

    公开(公告)日：1982-04-16

    申请号：KR770002744

    申请日：1977-11-25

    Applicant: HOECHST AG

    Inventor： GEBERT V ,  CARTHEUSER C ,  THORWAST W ,  KOMAREK J

    IPC: C07C83/04

    Abstract: O-Alkylated hydroxylamine and acid added salts of formula I [X=DR1,SR1(R1=H, C1-C6 alkyl, C3-C6 cycloalkyl, haloalkyl) or NR2R3(R2,R3 = H, C1-C6 alkyl, C3-C7 cycloalkyl substituted with OH, C1-C4 alkoxy carbonyl were prepd. by two methods. Thus, MeC(oEt):NOH was added to Na in EtOH, then C1CH2CH(OH)CH2OH and the mixt. refluxed 30 min, and the product(64.5 % yield) MeC(oEt):NOCH2CH(OH)CH2OH deblocked by refluxing 15 min with 2N HC1 to give 93.4 % H2NOCH2CH(OH)CH2OHHCl. The title compds. are used as an antihypertensives.

    PROCESS FOR PREPARING SUBSTITUTED 0-PROPYLOXIMES
    2.
    发明授权
    PROCESS FOR PREPARING SUBSTITUTED 0-PROPYLOXIMES 失效

    公开(公告)号：KR810000559B1

    公开(公告)日：1981-06-01

    申请号：KR770003022

    申请日：1977-12-24

    Applicant: HOECHST AG

    Inventor： GREVE H ,  KOMAREK J ,  GEBERT U ,  THORWART W ,  POPENDIKER K ,  CARTHEUSER C

    IPC: C07D211/14 ,  C07D295/08

    Abstract: Substituted O-propyloximes(I; R1 = H, carboxyl, C1-6 alkyl or alkenyl; R2 = H, C1-3 alkyl, R3 = H, hydroxy, acyloxy; R4 = H, C1-3 alkyl, phenyl group; R5 = H, halogen, C1-2 alkoxy, hydroxy group; X = N, methyl; M = H, alkaline metal, alkali earth metal cation; n = 1 or valence of cation; Y = halogen, active sulfonic ester; Z = halogen, active sulfonic ester), useful for treatment of catatonia, were prepd. by reaction of O-alkylated oxime(II) and compd.(III). The carbonyl compd.(IV) or its active derivs. were reacted with hydroxylamine derivs.(V) to give intermediate(II).

    3.
    发明专利
    未知

    公开(公告)号：DK145676B

    公开(公告)日：1983-01-24

    申请号：DK321574

    申请日：1974-06-14

    Applicant: HOECHST AG

    Inventor： MOHLER W ,  JAYME M ,  KOMAREK J

    IPC: A61K31/52 ,  A61K31/522 ,  A61P7/02 ,  A61P9/08 ,  C07D473/06 ,  C07D473/04

    Abstract: Compounds of general formula (I) wherein one of the groups R1 and R3 is a straight-chain or branched oxoalkyl group consisting from 5 to 8 carbon atoms and the oxygen atom is attached to a non-terminal carbon atom and is separated from the nearest ring nitrogen atom by at least 3 carbon atoms in ( omega -1)-oxoalkyl groups and by at least 4 carbon atoms in oxoalkyl groups in which the oxygen atom is separated from the terminal carbon atom by more than one carbon atom, R2 and the other one of groups R1 and R3 are straight chain or branched alkyl groups containing from 1 to 12 carbon atoms but wherein that group R1 or R3 which is other than an oxoalkyl group may also be hydrogen, one nitrogen-bound substituent being hydrogen or alkyl containing more than 1 carbon atom, and physiologically acceptable acid addition salts thereof, a process for their preparation and pharmaceutical compositions containing said compounds.

    4.
    发明专利
    未知

    公开(公告)号：SE423631B

    公开(公告)日：1982-05-17

    申请号：SE7407913

    申请日：1974-06-14

    Applicant: HOECHST AG

    Inventor： MOHLER W ,  JAYME M ,  KOMAREK J

    IPC: A61K31/52 ,  A61K31/522 ,  A61P7/02 ,  A61P9/08 ,  C07D473/06

    Abstract: Compounds of general formula (I) wherein one of the groups R1 and R3 is a straight-chain or branched oxoalkyl group consisting from 5 to 8 carbon atoms and the oxygen atom is attached to a non-terminal carbon atom and is separated from the nearest ring nitrogen atom by at least 3 carbon atoms in ( omega -1)-oxoalkyl groups and by at least 4 carbon atoms in oxoalkyl groups in which the oxygen atom is separated from the terminal carbon atom by more than one carbon atom, R2 and the other one of groups R1 and R3 are straight chain or branched alkyl groups containing from 1 to 12 carbon atoms but wherein that group R1 or R3 which is other than an oxoalkyl group may also be hydrogen, one nitrogen-bound substituent being hydrogen or alkyl containing more than 1 carbon atom, and physiologically acceptable acid addition salts thereof, a process for their preparation and pharmaceutical compositions containing said compounds.

    5.
    发明专利
    未知

    公开(公告)号：DK575277A

    公开(公告)日：1978-06-25

    申请号：DK575277

    申请日：1977-12-22

    Applicant: HOECHST AG

    Inventor： GEBERT U ,  THORWART W ,  KOMAREK J ,  CATHEUSER C ,  POPENDIKER K ,  GREVE H G

    IPC: C07D295/08 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/451 ,  A61K31/455 ,  A61K31/495 ,  A61K31/52 ,  A61K31/522 ,  A61P7/10 ,  A61P9/08 ,  A61P9/12 ,  A61P25/02 ,  A61P25/20 ,  C07D209/14 ,  C07D211/22 ,  C07D213/53 ,  C07D213/80 ,  C07D231/16 ,  C07D231/38 ,  C07D233/54 ,  C07D233/64 ,  C07D295/088 ,  C07D303/12 ,  C07D311/22 ,  C07D317/58 ,  C07D317/62 ,  C07D317/64 ,  C07D333/22 ,  C07D473/12 ,  C07D

    Abstract: Compounds of general formula (I) wherein R1 represents a radical selected from the group consisting of (a) hydrogen, carboxyl; (b) alkyl, alkenyl each having up to 6 carbon atoms and their phenyl substituted derivatives; (c) at most binuclear unsubstituted aryl, at most binuclear aryl substituted by from 1 to 3 substituents selected from the group consisting of alkyl and alkoxy each having up to 6 carbon atoms, benzloxy, haloalkyl having up to 2 carbon atoms, halogen, cyano and nitro; amino, carboxyl and hydroxy; amino, carboxyl and hydroxy each being substituted by alkyl having at most 2 carbon atoms, methylenedioxy groups and O- -hydroximinom ethyl groups; (d) at most bicyclic unsubstituted heteroaromatic group having 1 to 4 heteroatoms selected from the group consisting of nitrogen, one sulphur and one oxygen in the ring system and such a heteroaromatic group being substituted by at most 3 substituents selected from the group consisting of alkyl, alkoxy each having up to 2 carbon atoms, phenylalkyl having up to 3 carbon atoms in the alkyl moiety, halogen, methylamino and dimethylamino; R2 represents a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, cycloalkyl having up to 6 carbon atoms and phenyl; and R1 and R2, together with the carbon atom to which they are attached, form a radical selected from the group consisting of fluorene-9-ylidene and a cycloaliphatic group having up to 10 carbon atoms and such a cycloaliphatic group containing a hydrocarbon bridging group; R3 represents a member selected from the group consisting of hydrogen hydroxy and acyloxy; R4 represents a member selected from the group consisting of hydrogen alkyl having up to 3 carbon atoms and phenyl; R5 represents a member selected from the group consisting of halogen, alkoxy having up to 2 carbon atoms and hydroxy; and X represents a member selected from the group consisting of nitrogen and methine and physiologically acceptable acid addition salts thereof; a pharmaceutical composition containing said compounds.

    6.
    发明专利
    未知

    公开(公告)号：DK321574A

    公开(公告)日：1975-02-10

    申请号：DK321574

    申请日：1974-06-14

    Applicant: HOECHST AG

    Inventor： MOHLER W ,  JAYME M ,  KOMAREK J

    IPC: A61K31/52 ,  A61K31/522 ,  A61P7/02 ,  A61P9/08 ,  C07D473/06 ,  C07D

    Abstract: Compounds of general formula (I) wherein one of the groups R1 and R3 is a straight-chain or branched oxoalkyl group consisting from 5 to 8 carbon atoms and the oxygen atom is attached to a non-terminal carbon atom and is separated from the nearest ring nitrogen atom by at least 3 carbon atoms in ( omega -1)-oxoalkyl groups and by at least 4 carbon atoms in oxoalkyl groups in which the oxygen atom is separated from the terminal carbon atom by more than one carbon atom, R2 and the other one of groups R1 and R3 are straight chain or branched alkyl groups containing from 1 to 12 carbon atoms but wherein that group R1 or R3 which is other than an oxoalkyl group may also be hydrogen, one nitrogen-bound substituent being hydrogen or alkyl containing more than 1 carbon atom, and physiologically acceptable acid addition salts thereof, a process for their preparation and pharmaceutical compositions containing said compounds.

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