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    4.
    发明专利
    未知

    公开(公告)号：DE59209745D1

    公开(公告)日：1999-10-21

    申请号：DE59209745

    申请日：1992-11-23

    Applicant: HOECHST AG

    Inventor： FRICK WENDELIN ,  MUELLER GUENTER ,  MUELLNER STEFAN ,  BREIPOHL GERHARD

    IPC: A61K38/28 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07K5/087 ,  C07K5/093 ,  C07K5/097 ,  C07K7/06 ,  C07K7/08 ,  C07K9/00

    Abstract: Peptides with insulin-like activity and the formula I where C is a hydrogen atom, amino-acid residue, substituted amino-acid residue or sugar residue, D is an amino-acid residue, phosphoamino-acid residue, sugar residue, covalent bond or hydroxyl radical, E is a hydrogen atom, hydroxyl radical, substituted sugar residues, substituted alkyldiamine or glycerol residue, R is (C1-C4)-alkyl, =O or -O-(C1-C4)-alkyl, R is a sulphur protective group, SO2, SO3, (C1-C3)-alkyl, O2 radical, O3 radical, or hydrogen atom, R or R is, independently of one another, hydrogen or methyl, and W is an integer 1 or 2, the preparation and use thereof for the treatment of diabetes mellitus or non-insulin-dependent diabetes are described.

    8.
    发明专利
    未知

    公开(公告)号：NO301018B1

    公开(公告)日：1997-09-01

    申请号：NO932635

    申请日：1993-07-21

    Applicant: HOECHST AG

    Inventor： AHLERS MICHAEL ,  GLOMBIK HEINER ,  MUELLNER STEFAN ,  WALCH AXEL

    IPC: A61P3/06 ,  C08F8/12 ,  A61K31/785 ,  C08F26/00 ,  C08F26/02 ,  C08F226/00

    Abstract: The invention relates to crosslinked, nitrogen-containing vinyl copolymers containing units of the formula I and the physiologically acceptable salts thereof, where, in formula I, A1, A2, R, w, x, y and z are as defined, to a process for their preparation, and to the use of the compounds as medicaments (drugs, pharmaceuticals), active compound (active ingredient) carriers and as foodstuff auxiliaries.

    Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders
    10.
    发明专利
    Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders 未知

    公开(公告)号：ZA96540B

    公开(公告)日：1996-08-15

    申请号：ZA96540

    申请日：1996-01-24

    Applicant: HOECHST AG

    Inventor： GRAEVE ROLF ,  THORWART WERNER ,  RAISS RUTH ,  WIETHMANN KLAUS ULRICH ,  MUELLNER STEFAN

    IPC: A61K31/66 ,  A61K31/665 ,  A61P9/00 ,  A61P29/00 ,  A61P43/00 ,  B01J23/44 ,  B01J25/02 ,  B01J31/02 ,  C07F9/38 ,  C07F9/40 ,  C07F9/58 ,  C07F9/6533 ,  C07F9/655 ,  C07F9/6553 ,  C07F9/6571 ,  C07F9/6574 ,  C07F9/6596 ,  C07F ,  C07D ,  A61K

    Abstract: Medicaments contg. an amino-, cyano- or carboxy-substd. phenylalkane- or phenylalkene-phosphonic acid deriv. of formula (I) and/or its salt and/or stereoisomer are claimed. R1, R2 = R' or R"; or R1+R2 = OCH2O or OCH2CH2O; R3 = H or as for R2; R5 = CN, CH2NHR9 or COOR10; or R1+R5 are bonded, to give a bicyclic cpd. of formula (Ia); R6, R7 = H or 1-6C alkyl; or R1+R7 are bonded, to give a bicyclic cpd. of formula (Ib); R' = OH, 1-12C alkoxy (opt. monosubstd. by COOH or CO-O-(1-12C) alkyl), 3-12C cycloalkoxy, 3-6C alkenyloxy, 1-3Calkoxy( substd. by 5-7C cycloalkyl, heteroaryl (where the heteroatoms are N, S and/or O), Het or phenyl), benzyloxy (mono- to tri-substd. by halomethyl or 1-3C alkoxy) or phenoxy (mono- to tri-substd. by 1-3C alkoxy); R" = OCOR8, OSO2R8, OCH2P(O)(OR8)2 or substd. phenylmethoxy of formula (a); Het = 5 or 6 membered heterocycloalkyl (where the heteroatoms are N, S and/or O, opt. mono- to tri-substd. by 1-3C alkyl); R8 = H or 1-4C alkyl; R9 = H or 2-4C alkanoyl; R10 = H, 1-6C alkyl (opt. substd. by 1-4 of COOH, (1-3C) alkoxy-carbonyl, N(R)2 or morpholino) or trialkylsilyl; R = H or 1-3C alkyl; X-A = (CH=CH-CH=CH-CH) (sic), (CH2CH2CH2CH2CH), (CH2CH2CH2CH2CH), (CH2CH) or (CH=C); heteroatoms are N, S and/or O. Cpds. (I) and their salts and stereoisomers are new, provided that: (1) if R5 = CN, then at most one of R1-R3 = OH; (2) if R10 = H, then none of R1-R3 = OH; (3) if R10 = Me, Et or t-Bu, then R1-R3 are not OMe; (4) the O,O-dimethyl and O,O-diethyl esters of 1-(ethoxycarbonyl)-2-(3,4-methylenedioxyphenyl)-ethanephosphonic acid are excluded; (5) X-A is not (CH2)4CH or (CH=CH-CH=CH-CH); and (6) X-A may also be (CH=CH-CH=C).

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