公开(公告)号：NZ223384A

公开(公告)日：1989-11-28

申请号：NZ22338488

申请日：1988-02-02

Applicant: HOECHST AG

Inventor： ENGLERT H C ,  LANG H-J ,  MANIA D ,  SCHOLKENS B ,  KLAUS E

IPC: A61K31/40 ,  A61K31/41 ,  A61K31/535 ,  A61K31/54 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  A61K31/395 ,  A61K31/415 ,  A61K31/445 ,  A61K31/42 ,  A61K31/425 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505

Abstract: N-Benzopyranyllactams of the formula I in which R' represents CN, NO2 or SOn-Ar; where n = 1 or 2, Ar represents an aromatic or heteroaromatic system which is unsubstituted or substituted and p represents 1 or 2, R represents H, OH, (C1-C2)-alkoxy, (C1-C2)-alkyl, halogen or NR R , where R and R are identical or different and represent H, (C1-C2)-alkyl or (C1-C2)-alkylcarbonyl, R and R are identical or different and represent alkyl having 1-4 C atoms, the abovementioned meanings of R and R can also be exchanged, X represents a chain (CH2)m, which is substituted by at least 1 and at most 2m-1 (C1-C2)-alkyl groups, and can also be interrupted by a heteroatom Y having the meaning O, NR or S and R denotes H or (C1-C4)-alkyl and m represents 2, 3 or 4, are described. They have hypotensive activity and/or ureter-relaxing activity.