公开(公告)号：DE19654180A1

公开(公告)日：1998-06-25

申请号：DE19654180

申请日：1996-12-23

Applicant: HOECHST AG

Inventor： BOGDANOVIC SANDRA DR ,  BELLER MATTHIAS PROF DR ,  ZAPF ALEXANDER ,  KRAUTER JUERGEN

IPC: B01J31/24 ,  C07H15/203 ,  C07H17/00 ,  C07H1/00

Abstract: The invention relates to a method for producing phosphanes of the generic formula (I) Ar 3-xP(Ar (OZ)y)x, in which Ar and Ar independently of each other represent aromatic C6-20 radicals possibly substituted by halogen atoms, carboxyl groups, hydroxyl groups, alkyl C1-6 groups, phenyl groups or naphthyl groups, or represent heteroaromatic C4-9 radicals, whereby Ar has one free valence and Ar has y+1 free valences; Z is a carbohydrate radical with a glycosidic bond; x has a value of 1, 2 or 3; and y has a value of 1 or 2. According to said method, (1) carbohydrate halogenoses of the generic formula (II) Z'-X, in which Z' represents a radical Z as described above, in which the hydroxyl groups are substituted by protective groups and X represents Br, Cl or F, are reacted with a phosphane of the generic formula (III) Ar 3-xP(Ar (OH)y)x, in which Ar , Ar , x and y have the meaning given above, in a multiple-phase reaction medium in the presence of a base and a phase-transfer catalyst, to yield a phosphane of the generic formula (IV) Ar 3-xP(Ar (OZ')y)x, in which Ar , Ar , x, y and Z' have the meaning given above, and (2) the protective groups are separated from Z'.