公开(公告)号：DE2837022A1

公开(公告)日：1980-03-06

申请号：DE2837022

申请日：1978-08-24

Applicant: HOECHST AG

Inventor： KUEMMERLE KURT DR ,  HEISE HARTMUT DR

IPC: C07B31/00 ,  C07C5/03 ,  C07C5/10 ,  C07C29/141 ,  C07C29/145 ,  C07C29/17 ,  C07C29/20 ,  C07C37/07 ,  C07C67/00 ,  C07C209/48 ,  C07D295/023 ,  C07D307/08 ,  C07D307/12 ,  C07B1/00 ,  C07C5/02 ,  C07C29/00 ,  C07C37/00 ,  C07C67/30 ,  C07C85/11 ,  C07C102/00 ,  C07D211/02

公开(公告)号：DE2609835A1

公开(公告)日：1977-09-22

申请号：DE2609835

申请日：1976-03-10

Applicant: HOECHST AG

Inventor： KUEMMERLE KURT DR ,  HEISE HARTMUT DR ,  HILLE ERNST DR

IPC: C07B61/00 ,  B01J23/00 ,  B01J23/40 ,  B01J23/74 ,  B01J31/00 ,  B01J31/02 ,  C07C20060101 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C235/16 ,  C07C235/24 ,  C07C103/34

Abstract: The liquid-phase catalytic hydrogenation of N-acetoacetyl arylamides to yield 3-hydroxybutyric acid arylamides proceeds much faster when amines, phosphines or trialkylphosphates are added. Thus, even with lower hydrogen pressures and at lower temperatures with a lower catalyst concentration, shorter reaction times are sufficient.

公开(公告)号：DE2240849A1

公开(公告)日：1974-03-14

申请号：DE2240849

申请日：1972-08-19

Applicant: HOECHST AG

Inventor： KUEMMERLE KURT DR ,  ALBERS ARNOLD DR ,  HILLE ERNST DR ,  HEISE HARTMUT DR

IPC: C08G18/48 ,  C07C85/10

Abstract: Title cpds are prepared by hydrogenating the corresp. nitrobenzenes in aq. phase, using Ni catalysts, and adjusting the pH to 6-7.5 by addn. of oxyacids of 3-or 5-valent P, or of B, CO2 or low-mol. carboxylic acids and strong bases, or the corresp. salts; the additives are metered in such a way that the pH does not fall below the above limit. Nitrobenzenes carrying the above substits. cannot be hydrogenated by previous methods. Only 0.01-10 wt. % Ni catalyst is needed. Lower temps., e.g. 20-120 degrees C, can be used. Aminoacids have esp. strong stabilising effect on the pH.

公开(公告)号：DE3003254A1

公开(公告)日：1981-08-20

申请号：DE3003254

申请日：1980-01-30

Applicant: HOECHST AG

Inventor： KUEMMERLE KURT DR ,  HEISE HARTMUT DR

IPC: C07B31/00 ,  B01J23/00 ,  C07B61/00 ,  C07C1/22 ,  C07C5/02 ,  C07C5/03 ,  C07C29/132 ,  C07C29/145 ,  C07C29/17 ,  C07C29/19 ,  C07C29/20 ,  C07C67/00 ,  C07C209/48 ,  C07D211/02 ,  C07D295/023 ,  C07D307/08 ,  C07B1/00 ,  C07C31/135 ,  C07C85/12 ,  C07C87/00

公开(公告)号：CH626326A5

公开(公告)日：1981-11-13

申请号：CH281777

申请日：1977-03-07

Applicant: HOECHST AG

Inventor： KUEMMERLE KURT DR ,  HEISE HARTMUT DR ,  HILLE ERNST DR

IPC: C07B61/00 ,  B01J23/00 ,  B01J23/40 ,  B01J23/74 ,  B01J31/00 ,  B01J31/02 ,  C07C20060101 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C235/16 ,  C07C235/24 ,  C07C103/34

Abstract: The liquid-phase catalytic hydrogenation of N-acetoacetyl arylamides to yield 3-hydroxybutyric acid arylamides proceeds much faster when amines, phosphines or trialkylphosphates are added. Thus, even with lower hydrogen pressures and at lower temperatures with a lower catalyst concentration, shorter reaction times are sufficient.

公开(公告)号：DE2848979A1

公开(公告)日：1980-05-22

申请号：DE2848979

申请日：1978-11-11

Applicant: HOECHST AG

Inventor： KUEMMERLE KURT DR ,  HEISE HARMUT DR

IPC: C07D307/08