公开(公告)号：SE7810895L

公开(公告)日：1979-04-20

申请号：SE7810895

申请日：1978-10-19

Applicant: HOECHST AG

Inventor： MCFADDEN A R ,  ALLEN R C ,  LEE T B K

IPC: A61K31/335 ,  A61P25/04 ,  A61P29/00 ,  C07D295/185 ,  C07D313/12

Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.

公开(公告)号：DK59680A

公开(公告)日：1980-08-14

申请号：DK59680

申请日：1980-02-12

Applicant: HOECHST AG

Inventor： LEE T B K

IPC: C07D495/04 ,  C07D

Abstract: Isopropyl 4,10-dihydro-10-oxothieno[3,2-c][1]benzoxepin-8-acetate is synthesized from 4-(2-carboxy-3-thienylmethoxy)phenylacetic acid by a process comprising acid halide formation, ring closure catalyzed by aluminum trihalide and esterification with isopropyl alcohol. The three reaction steps are carried out successively in the same reactor without any isolation or purification of intermediate products and a surprisingly high overall yield is obtained. Additionally, a valuable chemical, aluminum isopropoxide is obtained as a by-product of this process and significant advantages in terms of environmental pollution and waste water costs are achieved.

公开(公告)号：SE8301997L

公开(公告)日：1983-04-11

申请号：SE8301997

申请日：1983-04-11

Applicant: HOECHST AG

Inventor： MCFADDEN A R ,  ALLEN R C ,  LEE T B K

IPC: A61K31/335 ,  A61P25/04 ,  A61P29/00 ,  C07D295/185 ,  C07D313/12

Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.

公开(公告)号：SE8301997D0

公开(公告)日：1983-04-11

申请号：SE8301997

申请日：1983-04-11

Applicant: HOECHST AG

Inventor： MCFADDEN A R ,  ALLEN R C ,  LEE T B K

IPC: A61K31/335 ,  A61P25/04 ,  A61P29/00 ,  C07D295/185 ,  C07D313/12

Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.

公开(公告)号：SE7810895A

公开(公告)日：1979-04-20

申请号：SE7810895

申请日：1978-10-19

Applicant: HOECHST AG

Inventor： MCFADDEN A R ,  ALLEN R C ,  LEE T B K

IPC: A61K31/335 ,  A61P25/04 ,  A61P29/00 ,  C07D295/185 ,  C07D313/12

CPC classification number: C07D295/185 ,  C07D313/12