公开(公告)号：KR820000581B1

公开(公告)日：1982-04-15

申请号：KR820000803

申请日：1982-02-23

Applicant: HOECHST AG

Inventor： ALLEN R ,  MCFADDEN A ,  KIN LEE T

IPC: A61K31/335 ,  C07D313/12

Abstract: Title compd. I with antiinflammatory and analgesic effect, was prepared. Thus, 4-benzyloxy-3-carboxyphenyl acetic acid was reacted with thionyl chloride to give 4-benzyloxy-3-(chlorocarbonyl)phenyl acetyl chloride, which was dissolved in methylene chloride-nitromethane mixture and reacted with equi-mole of aluminium chloride.

公开(公告)号：KR820000475B1

公开(公告)日：1982-04-07

申请号：KR780003135

申请日：1978-10-17

Applicant: HOECHST AG

Inventor： MCFADDEN A ,  KIN LEE T ,  ALLEN R

IPC: A61K31/335 ,  C07D313/12

Abstract: Title compd(I), useful as antiphlogistics and analogesics, was prepd. by the cyclization of 4-benzyloxy-3-carboxyphenylacetic acid(III). Thus, a compd. contg. 30.0 g 5-acetyl salicylic acid, 9.0 g sulfur and 54ml morpholine was reacted at 140-145oC for 19 hr, extracted with ether, and acidified to give 3-carboxy-4-hydroxyphenylthioacetmorpholide(m.p. 196-198≦̸C.).

公开(公告)号：KR810000563B1

公开(公告)日：1981-06-01

申请号：KR760003114

申请日：1976-12-17

Applicant: HOECHST AG

Inventor： MCFADDEN A ,  HELSLEY R

IPC: C07D313/12

Abstract: Title compds. (I; Y,Z = H, C1-4alkyl, alkoxy, halogen, CF3; n,p = 1-3), useful as anti-inflammatory agent, were prepd. by esterification of II and III. Thus, 4.0 g PCl5 were added to 60 g 6,11-dihydro-11-oxodibenz b,e oxepine-2-acetic acid in 70 ml benzene while cooling and were stirred for 4hr. The reactant was melted in 30 ml CHCl3 and 70 ml of the mixt. was reacted with 2.2 g benzyl alcohol and 2.0 g triethylamine to give 6,11-dihydro-11-oxodibenz b,e, oxepine-2-acetate(m.p.: 82-84≦̸C).

公开(公告)号：ZA7703305B

公开(公告)日：1978-04-26

申请号：ZA7703305

申请日：1977-06-02

Applicant: HOECHST AG

Inventor： MCFADDEN A ,  HELSLEY G

IPC: A61K31/335 ,  A61P29/00 ,  C07D313/12 ,  C07C

CPC classification number: C07D313/12

公开(公告)号：PH13197A

公开(公告)日：1980-01-18

申请号：PH19839

申请日：1977-06-03

Applicant: HOECHST AG

Inventor： MCFADDEN A ,  HEISLEY G

IPC: A61K31/335 ,  A61P29/00 ,  C07D313/12 ,  C07D313/02

Abstract: Benzyl and related esters of 6,11-dihydrodibenz[b,e]oxepin-acetic and method for preparing same are described. These compounds are valuable as systemic and topical anti-inflammatory agents.

公开(公告)号：ZA773305B

公开(公告)日：1978-04-26

申请号：ZA773305

申请日：1977-06-02

Applicant: HOECHST AG

Inventor： MCFADDEN A ,  HELSLEY G

IPC: A61K31/335 ,  A61P29/00 ,  C07D313/12 ,  C07C

Abstract: Benzyl and related esters of 6,11-dihydrodibenz[b,e]oxepin-acetic and method for preparing same are described. These compounds are valuable as systemic and topical anti-inflammatory agents.

公开(公告)号：ZA7405665B

公开(公告)日：1976-02-25

申请号：ZA7405665

申请日：1975-09-05

Applicant: HOECHST AG

Inventor： HOFFMANN D ,  HELSLEY G ,  MCFADDEN A

IPC: A61K20060101 ,  C07D20060101 ,  C07D313/12

公开(公告)号：ZA745665B

公开(公告)日：1976-02-25

申请号：ZA745665

申请日：1975-09-05

Applicant: HOECHST AG

Inventor： HOFFMANN D ,  HELSLEY G ,  MCFADDEN A

IPC: A61K20060101 ,  C07D20060101 ,  C07D313/12