公开(公告)号：KR820000475B1

公开(公告)日：1982-04-07

申请号：KR780003135

申请日：1978-10-17

Applicant: HOECHST AG

Inventor： MCFADDEN A ,  KIN LEE T ,  ALLEN R

IPC: A61K31/335 ,  C07D313/12

Abstract: Title compd(I), useful as antiphlogistics and analogesics, was prepd. by the cyclization of 4-benzyloxy-3-carboxyphenylacetic acid(III). Thus, a compd. contg. 30.0 g 5-acetyl salicylic acid, 9.0 g sulfur and 54ml morpholine was reacted at 140-145oC for 19 hr, extracted with ether, and acidified to give 3-carboxy-4-hydroxyphenylthioacetmorpholide(m.p. 196-198≦̸C.).

公开(公告)号：KR820000581B1

公开(公告)日：1982-04-15

申请号：KR820000803

申请日：1982-02-23

Applicant: HOECHST AG

Inventor： ALLEN R ,  MCFADDEN A ,  KIN LEE T

IPC: A61K31/335 ,  C07D313/12

Abstract: Title compd. I with antiinflammatory and analgesic effect, was prepared. Thus, 4-benzyloxy-3-carboxyphenyl acetic acid was reacted with thionyl chloride to give 4-benzyloxy-3-(chlorocarbonyl)phenyl acetyl chloride, which was dissolved in methylene chloride-nitromethane mixture and reacted with equi-mole of aluminium chloride.

公开(公告)号：KR820000562B1

公开(公告)日：1982-04-14

申请号：KR820000779

申请日：1982-02-22

Applicant: HOECHST AG

Inventor： SETESCAK L ,  SHUTSKE G ,  ALLEN R

IPC: C07D275/06 ,  C07D413/04 ,  C07D417/04

Abstract: 1,2-Benzisoxazolyloxy acetic acids and derivatives of formula I[R = H, low alkyl, cycloalkyl; R1 = COOH, CHO, CN, 5-tetrazolyl; R2,R3,R4 = H, alkyl, halogen; R5,R6=H, low alkyl, A,A1=O or S were prepd. Thus 2.3 dichlorophenoxy acetic acid reacted with 2-fluorobenzoyl chloride to give 2.3 dichloro-4-(2-fluorobenzoyl)phenoxy acetic acid, which was converted to 2.3 dichloro-4-(2-fluorobenzohydroxymoyl)phenoxy acetic acid[II II was hydrolyzed to [7-chloro-3-(2-fluorophenyl -1,2-benzisoxazol-6-yl oxy acetic acid. The title compds. have diuretic, antihypertensive and uricosuric acitvity.

公开(公告)号：KR820000476B1

公开(公告)日：1982-04-07

申请号：KR780003502

申请日：1978-11-17

Applicant: HOECHST AG

Inventor： SHUTSKE G ,  ALLEN R ,  SETESCAK L

IPC: C07D261/20 ,  C07D275/06 ,  C07D413/12 ,  C07D417/12

Abstract: Titla compds. (I; R = H, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, tricycloalkyl, cycloalkyl lower alkyl, cycloalkenyl lower alkyl, boxyl, -COZ, -CH2OH, -CHO, -CH; R2, R3, R4 = H, halogen, lower alkyl; R5, R6 = H, lower alkyl; A, A' = O, S; Z = Cl, Br, F; M, n = 1,2,3), useful as diuretic, were prepd. by reacting compd.(II) with compd.(III) followed by treatment. The treatment comprise hydrolysis, oxidn., N(R7)(R8) or NH2OH treatment, NHO3 treatment in glacial acetic acid, and dealkylation.

公开(公告)号：ZA8001868B

公开(公告)日：1981-04-29

申请号：ZA8001868

申请日：1980-03-28

Applicant: HOECHST AG

Inventor： ALLEN R ,  KLIOZE S

IPC: A61K31/495 ,  A61P9/12 ,  C07D213/74 ,  C07D295/26 ,  C07D ,  A61K

CPC classification number: C07D213/74 ,  C07D295/26

公开(公告)号：ZA7605111B

公开(公告)日：1977-08-31

申请号：ZA7605111

申请日：1976-08-25

Applicant: HOECHST AG

Inventor： KLIOZE S ,  ALLEN R

IPC: C07D295/22 ,  A61K31/495 ,  A61P7/10 ,  A61P9/12 ,  C07D209/48 ,  C07D295/26 ,  C07D

CPC classification number: C07D209/48 ,  C07D295/26

公开(公告)号：PH14355A

公开(公告)日：1981-06-03

申请号：PH15774

申请日：1974-04-24

Applicant: HOECHST AG

Inventor： ALLEN R ,  BRIAN ANDERSON V

IPC: C07D207/00 ,  C07D209/00

公开(公告)号：ZA801868B

公开(公告)日：1981-04-29

申请号：ZA801868

申请日：1980-03-28

Applicant: HOECHST AG

Inventor： ALLEN R ,  KLIOZE S

IPC: A61K31/495 ,  A61P9/12 ,  C07D213/74 ,  C07D295/26 ,  C07D ,  A61K

公开(公告)号：ZA7806528B

公开(公告)日：1979-10-31

申请号：ZA7806528

申请日：1978-11-20

Applicant: HOECHST AG

Inventor： SETESCAK L ,  ALLEN R ,  SHUTSKE G

IPC: A61K31/42 ,  C07C20060101 ,  C07D261/20 ,  C07C

公开(公告)号：ZA786528B

公开(公告)日：1979-10-31

申请号：ZA786528

申请日：1978-11-20

Applicant: HOECHST AG

Inventor： SETESCAK L ,  ALLEN R ,  SHUTSKE G

IPC: A61K31/42 ,  C07C20060101 ,  C07D261/20 ,  C07C