公开(公告)号：KR800001132B1

公开(公告)日：1980-10-12

申请号：KR790002788

申请日：1979-08-16

Applicant: HOECHST AG

Inventor： BORMANN D ,  MERKEL W ,  MUSHABECK R

IPC: C07D207/00

Abstract: Heterocylic group substituted 5-sulfamoyl benzoic acid and its salts (I; R1, R2 = H, C1-4 alkyl; when R1 is H, R2 is C2-5 alkoxymethyl, phenoxymethyl or phenylthiomethyl; R3 = H, C1-4 alkyls, C5-6 cycloalkyl, phenyl, benzyl; X = halogen, CF3, CCl3, C1-6 satd. or unsatd. alkyl or alkoxy, benzyl, OR4, SR4, SOR4, SO2R4 (R4 = Hal, OH, NH2, CF3, NO2); A= halogen, alkyl, aralkyl or side chain aryl group substituted C1-3 alkylene or singled bond; L = eliminatig group), useful as diuretic agent, were prepd. by treating sulfamoyl benzoic acid derivs. (II) with acid or base for eliminating HL group.

公开(公告)号：KR800001133B1

公开(公告)日：1980-10-12

申请号：KR740003720

申请日：1974-09-28

Applicant: HOECHST AG

Inventor： BORMANN D ,  MERKEL W ,  MUSHABECK R

IPC: C07D207/00

Abstract: Title compds. (I; R1, R2 = H, C1-4 alkyl, alkoxymethyl, phenoxymethyl, phenylthiomethyl; R3 = H, C1-4 alkyl, C5-6 cycloalkyl, Ph, benzyl, benzhydryl, C3-5 alkanoyloxymethyl; x = halogen, CF3, CCl3, alkyl, alkoxy; A = single bond, substituted alkylene), useful diuretic, were prepd. from 3-substituted sulfamoyl benzoic acid derivs.(II, z = two H, one O) by redn. with HB complex in the presence of Lewis acid or various methods.

公开(公告)号：KR800001131B1

公开(公告)日：1980-10-12

申请号：KR790002786

申请日：1979-08-16

Applicant: HOECHST AG

Inventor： BORMANN D ,  MERKEL W ,  MUSHABECK R

IPC: C07D207/00

Abstract: Title compds. (I; R1, R2 = H, C1-4 alkyl; R3 = H, C1-4 alkyl, phenyl, benzyl, C3-5 alkanoyloxymethyl; X = halogen, CF3, C1-6 alkyl etc.; A = single bond or C1-3 alkylene), with diuretic and saluretic action are prepd. by treating 5-halo- genosulfonyl benzoic acid derivs.(II; Hal = halogen) with III. If, necessary a process such as adding hydrogen to double bond, inducing double bond, esterifying carboxylic acid, hydrolysing carboxylic ester, separating protected group and liberating hydroxyl, amino or mercapto group and treating carboxylic acid with base or acid can be accepted.