公开(公告)号：SE305211B

公开(公告)日：1968-10-21

申请号：SE869065

申请日：1965-06-30

Applicant: HOECHST AG

Inventor： MUELLER G ,  MERTEN R ,  WIRTZ S

IPC: C07C311/54 ,  C07C143/833

Abstract: Novel benzenesulphonyl ureas of the formula and physiologically acceptable salts thereof, wherein R and R1 are each a hydrogen or halogen atom or an alkoxy, acyl, alkyl, haloalkyl, aminoalkyl, hydroxyalkyl, alkenyl, haloalkenyl, aminoalkenyl or hydroxyalkenyl group and R1 may also be an amino or acylamino group are made by (a) reacting an R,R1-substituted benzenesulphonyl isocyanate, or a corresponding carbamic acid ester or halide thiocarbamic ester or urea with aminonortricyclene or its salts; (b) reacting a benzenesulphonamide or its salt with nortricyclyl-isocyanate, a nortricyclyl-carbamic ester or halide, a nortricyclyl thiocarbamic ester or nortricyclyl-urea; (c) reacting a benzenesulphonic acid N-halo-amide with nortricyclyl formamide; (d) reacting a benzenesulphonyl halide with nortricyclyl urea isourea ether, isothiourea ether, guanidine or parabanic acid and hydrolysing the resulting isourea, isothiourea, guanidine or parabanic acid derivatives; (e) treating a corresponding benzenesulphonyl thiourea to replace the sulphur atom by an oxygen atom or (f) oxidizing corresponding benzenesulphinyl or benzenesulpheny ureas. Pharmaceutical preparations having hypoglycaemic properties comprise the above compounds in admixture or conjunction with a carrier, preferably in unit dosage form adapted to oral administration e.g. tablets.