公开(公告)号：CZ290341B6

公开(公告)日：2002-07-17

申请号：CS255392

申请日：1992-08-19

Applicant: HOECHST AG

Inventor： MULLER GUNTER DR ,  TRIPIER DOMINIQUE DR ,  MULLNER STEFAN DR

IPC: A61K38/28 ,  A61K31/715 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/22 ,  C07K5/08 ,  C07K5/093 ,  C07K5/10 ,  C07K9/00 ,  C07K14/37 ,  C07K14/41 ,  C07K14/475 ,  C07K14/575 ,  C07K14/62 ,  C07K14/65 ,  C12P19/26 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865

Abstract: The present invention relates to phosphoinositol glycan compounds exhibiting insulin-like activity, which can be obtained by splitting of adenosine-3',5'-cyclic monophosphate-binding protein and/or physiologically acceptable salts thereof containing phosphoinositol glycan and 2-aminoethanol and physiologically acceptable salts thereof, process of their preparation and their use, particularly as medicaments intended especially for treating diabetes mellitus or insulin-independent diabetes.

公开(公告)号：ES2074740T3

公开(公告)日：1995-09-16

申请号：ES92101077

申请日：1992-01-23

Applicant: HOECHST AG

Inventor： AIGNER RUDOLF ,  MULLER GUNTER DR ,  SCHOLZ HANS JURGEN DR ,  WEHLE DETLEF DR

IPC: C07C213/02 ,  C07C213/04 ,  C07C215/10

Abstract: The novel process is based on the reaction of a dialkylamine, preferably dimethylamine or diethylamine, with a monohalopropanediol, preferably monochloropropanediol, in the presence of water. The reaction is carried out in the presence of 25 to 70% by weight of water and at a temperature of from 20 to 80 DEG C, the dialkylamine being employed in an amount of at least 2.5 mol per mol of monohalopropanediol. The novel process allows a high space-time-yield and also a high chemical yield of virtually pure dialkylaminopropanediol to be obtained.

公开(公告)号：ES2137937T3

公开(公告)日：2000-01-01

申请号：ES92119913

申请日：1992-11-23

Applicant: HOECHST AG

Inventor： FRICK WENDELIN DR ,  MULLER GUNTER DR ,  MULLNER STEFAN DR ,  BREIPOHL GERHARD DR

IPC: A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  A61K38/28 ,  C07K5/087 ,  C07K5/093 ,  C07K5/097 ,  C07K7/06 ,  C07K7/08 ,  C07K9/00

Abstract: Peptides with insulin-like activity and the formula I where C is a hydrogen atom, amino-acid residue, substituted amino-acid residue or sugar residue, D is an amino-acid residue, phosphoamino-acid residue, sugar residue, covalent bond or hydroxyl radical, E is a hydrogen atom, hydroxyl radical, substituted sugar residues, substituted alkyldiamine or glycerol residue, R is (C1-C4)-alkyl, =O or -O-(C1-C4)-alkyl, R is a sulphur protective group, SO2, SO3, (C1-C3)-alkyl, O2 radical, O3 radical, or hydrogen atom, R or R is, independently of one another, hydrogen or methyl, and W is an integer 1 or 2, the preparation and use thereof for the treatment of diabetes mellitus or non-insulin-dependent diabetes are described.

公开(公告)号：CZ284568B6

公开(公告)日：1999-01-13

申请号：CS387991

申请日：1991-12-18

Applicant: HOECHST AG

Inventor： MULLNER STEFAN DR ,  KONIG WOLFGANG DR ,  MULLER GUNTER DR

IPC: A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K1/113 ,  C07K5/08 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/62

Abstract: Short peptides of the formula I X-Y-A-B-C-Cys-D-E (I> in which A and B are an amino acid or a covalent bond, C and D are an amino acid or a substituted amino acid, E is a modified or unmodified amino acid or a covalent bond, X is a radical or hydrogen and Y is leucine or a covalent bond, or dimers of the peptides of the formula I with cystine as dimerisation component, the stereoisomeric forms thereof where appropriate or their physiologically tolerated salts, the preparation thereof, and their use for the treatment of diabetes mellitus are described.

公开(公告)号：CS9103879A3

公开(公告)日：1992-07-15

申请号：CS387991

申请日：1991-12-18

Applicant: HOECHST AG

Inventor： MULLNER STEFAN DR ,  KONIG WOLFGANG DR ,  MULLER GUNTER DR

IPC: A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K1/113 ,  C07K5/08 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/62 ,  A61K37/02

CPC classification number: C07K14/62 ,  A61K38/00

公开(公告)号：ES2130130T3

公开(公告)日：1999-07-01

申请号：ES91121624

申请日：1991-12-17

Applicant: HOECHST AG

Inventor： MULLNER STEFAN DR ,  KONIG WOLFGANG DR ,  MULLER GUNTER DR

IPC: A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K1/113 ,  C07K5/08 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/62

Abstract: Short peptides of the formula I X-Y-A-B-C-Cys-D-E (I> in which A and B are an amino acid or a covalent bond, C and D are an amino acid or a substituted amino acid, E is a modified or unmodified amino acid or a covalent bond, X is a radical or hydrogen and Y is leucine or a covalent bond, or dimers of the peptides of the formula I with cystine as dimerisation component, the stereoisomeric forms thereof where appropriate or their physiologically tolerated salts, the preparation thereof, and their use for the treatment of diabetes mellitus are described.

公开(公告)号：ES2096686T3

公开(公告)日：1997-03-16

申请号：ES92113897

申请日：1992-08-14

Applicant: HOECHST AG

Inventor： MULLER GUNTER DR ,  TRIPIER DOMINIQUE DR ,  MULLNER STEFAN DR

IPC: A61K38/28 ,  A61K31/715 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/22 ,  C07K5/08 ,  C07K5/093 ,  C07K5/10 ,  C07K9/00 ,  C07K14/37 ,  C07K14/41 ,  C07K14/475 ,  C07K14/575 ,  C07K14/62 ,  C07K14/65 ,  C12P19/26 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865

Abstract: Phosphoinositolglycan peptides, obtainable by cleavage of adenosine-3%,5%-cyclic monophosphate binding protein, which contain glucosamine, galactose, mannose, inositol, phosphoric acid, ethanolamine and a peptide containing the sequence Asn-Cys-Tyr, their preparation and use for the treatment of diabetes mellitus and non-insulin-dependent diabetes are described.

公开(公告)号：CZ9202553A3

公开(公告)日：1993-03-17

申请号：CS255392

申请日：1992-08-19

Applicant: HOECHST AG

Inventor： MULLER GUNTER DR ,  TRIPIER DOMINIQUE DR ,  MULLNER STEFAN DR

IPC: A61K38/28 ,  A61K31/715 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/22 ,  C07K5/08 ,  C07K5/093 ,  C07K5/10 ,  C07K9/00 ,  C07K14/37 ,  C07K14/41 ,  C07K14/475 ,  C07K14/575 ,  C07K14/62 ,  C07K14/65 ,  C12P19/26 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865 ,  C07K15/24

CPC classification number: C07K14/475 ,  A61K38/00 ,  C07K5/0827 ,  C07K5/1027 ,  C07K9/001 ,  C12P19/26

公开(公告)号：CZ255392A3

公开(公告)日：1993-03-17

申请号：CS255392

申请日：1992-08-19

Applicant: HOECHST AG

Inventor： MULLER GUNTER DR ,  TRIPIER DOMINIQUE DR ,  MULLNER STEFAN DR

IPC: A61K38/28 ,  A61K31/715 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/22 ,  C07K5/08 ,  C07K5/093 ,  C07K5/10 ,  C07K9/00 ,  C07K14/37 ,  C07K14/41 ,  C07K14/475 ,  C07K14/575 ,  C07K14/62 ,  C07K14/65 ,  C12P19/26 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865 ,  C07K15/24

Abstract: Phosphoinositolglycan peptides, obtainable by cleavage of adenosine-3%,5%-cyclic monophosphate binding protein, which contain glucosamine, galactose, mannose, inositol, phosphoric acid, ethanolamine and a peptide containing the sequence Asn-Cys-Tyr, their preparation and use for the treatment of diabetes mellitus and non-insulin-dependent diabetes are described.

公开(公告)号：CS387991A3

公开(公告)日：1992-07-15

申请号：CS387991

申请日：1991-12-18

Applicant: HOECHST AG

Inventor： MULLNER STEFAN DR ,  KONIG WOLFGANG DR ,  MULLER GUNTER DR

IPC: A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K1/113 ,  C07K5/08 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/62 ,  A61K37/02

Abstract: Short peptides of the formula I X-Y-A-B-C-Cys-D-E (I> in which A and B are an amino acid or a covalent bond, C and D are an amino acid or a substituted amino acid, E is a modified or unmodified amino acid or a covalent bond, X is a radical or hydrogen and Y is leucine or a covalent bond, or dimers of the peptides of the formula I with cystine as dimerisation component, the stereoisomeric forms thereof where appropriate or their physiologically tolerated salts, the preparation thereof, and their use for the treatment of diabetes mellitus are described.