公开(公告)号：DE3344912A1

公开(公告)日：1985-06-20

申请号：DE3344912

申请日：1983-12-13

Applicant: HOECHST AG

Inventor： MAUZ OTTO DR ,  NOETZEL SIEGFRIED DR ,  NEUMANN BERNHARD DR

IPC: A61K38/46 ,  A61K39/00 ,  A61K39/44 ,  A61K47/00 ,  A61K47/32 ,  B01D15/08 ,  B01J20/26 ,  B01J20/281 ,  B01J20/285 ,  C08F2/00 ,  C08F2/18 ,  C08F8/00 ,  C08F8/12 ,  C08F16/02 ,  C08F16/32 ,  C08F18/02 ,  C08F22/18 ,  C08F26/00 ,  C08F26/10 ,  C08F216/06 ,  C08F216/12 ,  C08F218/00 ,  C08F218/02 ,  C08F218/04 ,  C08F218/08 ,  C08F226/06 ,  C08J9/224 ,  C12N11/08 ,  G01N30/88 ,  G01N33/543

Abstract: For the contracting states : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A crosslinked polymer in the form of beads which substantially comprises vinyl acylate units and units of a crosslinking agent which has the formulae see diagramm : EP0150350,P12,F1 and/or see diagramm : EP0150350,P12,F2 where R1 and R2 in the formula (I) can be identical or different and each denotes vinyl-, 1-acyloxyvinyl, allyl- or 2-acyloxyallyl, A represents a divalent hydrocarbon radical of 2 to 8 carbon atoms, B in the formula (II) stands for a divalent hydrocarbon radical of 1 to 8 carbon atoms and X denotes acyloxy, the amount of theses crosslinking agent units accounting for 1 to 60 % by weight of the polymer, the acyloxy groups of the vinyl acylate units being present as such or having been partially or completely replaced by hydroxyl groups, and the average particle size of the beads being 20 to 800 mu m and the mean pore diameter being 2 to 10,000 nm. For the contracting state AT 1. A process for preparing a crosslinked polymer in the form of beads by copolymerizing vinyl acylate with a crosslinking agent and, if propriate, a further monomer copolymerizable with the vinyl acylate in ther presence of a dispersion medium and if desired partially or completely hydrolyzing the resulting polymer, wherein the crosslinking agent has the formulae see diagramm : EP0150350,P12,F1 and/or see diagramm : EP0150350,P12,F2 where R1 and R2 in the formula (I) can be identical or different and each denotes vinyl-, 1-acyloxyvinyl, allyl- or 2-acyloxyallyl, A represents a divalent hydrocarbon radical of 2 to 8 carbon atoms, B in the formula (II) stands for a divalent hydrocarbon radical of 1 to 8 carbon atoms and X denotes acyloxy, and the beads obtained have an average particle size of 10 to 800 mu m and an average pore diameter of 2 to 10,000 nm.

公开(公告)号：AT40388T

公开(公告)日：1989-02-15

申请号：AT84114854

申请日：1984-12-06

Applicant: HOECHST AG

Inventor： MAUZ OTTO DR ,  NOETZEL SIEFRIED DR ,  NEUMANN BERNHARD DR

IPC: A61K38/46 ,  A61K39/00 ,  A61K39/44 ,  A61K47/00 ,  A61K47/32 ,  B01D15/08 ,  B01J20/26 ,  B01J20/281 ,  B01J20/285 ,  C08F2/00 ,  C08F2/18 ,  C08F8/00 ,  C08F8/12 ,  C08F16/02 ,  C08F16/32 ,  C08F18/02 ,  C08F22/18 ,  C08F26/00 ,  C08F26/10 ,  C08F216/06 ,  C08F216/12 ,  C08F218/00 ,  C08F218/02 ,  C08F218/04 ,  C08F218/08 ,  C08F226/06 ,  C08J9/224 ,  C12N11/08 ,  G01N30/88 ,  G01N33/543

公开(公告)号：DE3476405D1

公开(公告)日：1989-03-02

申请号：DE3476405

申请日：1984-12-06

Applicant: HOECHST AG

Inventor： MAUZ OTTO DR ,  NOETZEL SIEFRIED DR ,  NEUMANN BERNHARD DR

IPC: A61K38/46 ,  A61K39/00 ,  A61K39/44 ,  A61K47/00 ,  A61K47/32 ,  B01D15/08 ,  B01J20/26 ,  B01J20/281 ,  B01J20/285 ,  C08F2/00 ,  C08F2/18 ,  C08F8/00 ,  C08F8/12 ,  C08F16/02 ,  C08F16/32 ,  C08F18/02 ,  C08F22/18 ,  C08F26/00 ,  C08F26/10 ,  C08F216/06 ,  C08F216/12 ,  C08F218/00 ,  C08F218/02 ,  C08F218/04 ,  C08F218/08 ,  C08F226/06 ,  C08J9/224 ,  C12N11/08 ,  G01N30/88 ,  G01N33/543

Abstract: For the contracting states : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A crosslinked polymer in the form of beads which substantially comprises vinyl acylate units and units of a crosslinking agent which has the formulae see diagramm : EP0150350,P12,F1 and/or see diagramm : EP0150350,P12,F2 where R1 and R2 in the formula (I) can be identical or different and each denotes vinyl-, 1-acyloxyvinyl, allyl- or 2-acyloxyallyl, A represents a divalent hydrocarbon radical of 2 to 8 carbon atoms, B in the formula (II) stands for a divalent hydrocarbon radical of 1 to 8 carbon atoms and X denotes acyloxy, the amount of theses crosslinking agent units accounting for 1 to 60 % by weight of the polymer, the acyloxy groups of the vinyl acylate units being present as such or having been partially or completely replaced by hydroxyl groups, and the average particle size of the beads being 20 to 800 mu m and the mean pore diameter being 2 to 10,000 nm. For the contracting state AT 1. A process for preparing a crosslinked polymer in the form of beads by copolymerizing vinyl acylate with a crosslinking agent and, if propriate, a further monomer copolymerizable with the vinyl acylate in ther presence of a dispersion medium and if desired partially or completely hydrolyzing the resulting polymer, wherein the crosslinking agent has the formulae see diagramm : EP0150350,P12,F1 and/or see diagramm : EP0150350,P12,F2 where R1 and R2 in the formula (I) can be identical or different and each denotes vinyl-, 1-acyloxyvinyl, allyl- or 2-acyloxyallyl, A represents a divalent hydrocarbon radical of 2 to 8 carbon atoms, B in the formula (II) stands for a divalent hydrocarbon radical of 1 to 8 carbon atoms and X denotes acyloxy, and the beads obtained have an average particle size of 10 to 800 mu m and an average pore diameter of 2 to 10,000 nm.

公开(公告)号：BR8406380A

公开(公告)日：1985-10-08

申请号：BR8406380

申请日：1984-12-12

Applicant: HOECHST AG

Inventor： MAUZ OTTO DR ,  NOETZEL SIEGFRIED DR ,  NEUMANN BERNHARD DR

IPC: A61K38/46 ,  A61K39/00 ,  A61K39/44 ,  A61K47/00 ,  A61K47/32 ,  B01D15/08 ,  B01J20/26 ,  B01J20/281 ,  B01J20/285 ,  C08F2/00 ,  C08F2/18 ,  C08F8/00 ,  C08F8/12 ,  C08F16/02 ,  C08F16/32 ,  C08F18/02 ,  C08F22/18 ,  C08F26/00 ,  C08F26/10 ,  C08F216/06 ,  C08F216/12 ,  C08F218/00 ,  C08F218/02 ,  C08F218/04 ,  C08F218/08 ,  C08F226/06 ,  C08J9/224 ,  C12N11/08 ,  G01N30/88 ,  G01N33/543 ,  C08J3/24 ,  C08K5/21 ,  C08K5/11

Abstract: For the contracting states : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A crosslinked polymer in the form of beads which substantially comprises vinyl acylate units and units of a crosslinking agent which has the formulae see diagramm : EP0150350,P12,F1 and/or see diagramm : EP0150350,P12,F2 where R1 and R2 in the formula (I) can be identical or different and each denotes vinyl-, 1-acyloxyvinyl, allyl- or 2-acyloxyallyl, A represents a divalent hydrocarbon radical of 2 to 8 carbon atoms, B in the formula (II) stands for a divalent hydrocarbon radical of 1 to 8 carbon atoms and X denotes acyloxy, the amount of theses crosslinking agent units accounting for 1 to 60 % by weight of the polymer, the acyloxy groups of the vinyl acylate units being present as such or having been partially or completely replaced by hydroxyl groups, and the average particle size of the beads being 20 to 800 mu m and the mean pore diameter being 2 to 10,000 nm. For the contracting state AT 1. A process for preparing a crosslinked polymer in the form of beads by copolymerizing vinyl acylate with a crosslinking agent and, if propriate, a further monomer copolymerizable with the vinyl acylate in ther presence of a dispersion medium and if desired partially or completely hydrolyzing the resulting polymer, wherein the crosslinking agent has the formulae see diagramm : EP0150350,P12,F1 and/or see diagramm : EP0150350,P12,F2 where R1 and R2 in the formula (I) can be identical or different and each denotes vinyl-, 1-acyloxyvinyl, allyl- or 2-acyloxyallyl, A represents a divalent hydrocarbon radical of 2 to 8 carbon atoms, B in the formula (II) stands for a divalent hydrocarbon radical of 1 to 8 carbon atoms and X denotes acyloxy, and the beads obtained have an average particle size of 10 to 800 mu m and an average pore diameter of 2 to 10,000 nm.