公开(公告)号：KR830000208A

公开(公告)日：1983-03-30

申请号：KR760000522

申请日：1976-03-04

Applicant: HOECHST AG

Inventor： BARTMANN WILHELM ,  REUSCHLING DIETER ,  TEUFEL HERMANN ,  BECK GERHARD ,  SEEGAR KARL

IPC: A61K31/557 ,  C07D333/16 ,  C07C177/00

Abstract: Title compds. I(R1,R2 = H, OH; R3 = α- or β-thienyl, α- or β-thienylmethyl, benzo[b thiophene, cyclopentano[b thiopene, cyclohexano[b thiopene; X = C1-7 straight-or sidechain alkylene, C2-8 alkoxyalkylene), exhibiting a hypotension activity and a urination activity, were prepd. by the reaction of lactol (II) and 4-carboxy-butyl-triphenylphosphonium bromide in NaH-dissolved dimethylsulfoxide in the presence of inert gas to give formula acid(II), which was acid hydrolyzed to give compds. I or their esters by eliminating tetrahydropyranyl protecting group.

公开(公告)号：JPS6341462A

公开(公告)日：1988-02-22

申请号：JP19054387

申请日：1987-07-31

Applicant: HOECHST AG

Inventor： REUSCHLING DIETER ,  GROEBEL BENGT-THOMAS

IPC: C07D213/89

公开(公告)号：JPS60209578A

公开(公告)日：1985-10-22

申请号：JP5471785

申请日：1985-03-20

Applicant: Hoechst Ag

Inventor： CLAUSS KARL ,  LINKIES ADOLF ,  REUSCHLING DIETER

IPC: A23L27/30 ,  B01J31/00 ,  B01J31/02 ,  B01J31/24 ,  C07B61/00 ,  C07C303/34 ,  C07C307/02 ,  C07C311/46 ,  C07D291/06

CPC classification number: C07D291/06

公开(公告)号：JPH0570627B2

公开(公告)日：1993-10-05

申请号：JP5471785

申请日：1985-03-20

Applicant: HOECHST AG

Inventor： CLAUSS KARL ,  LINKIES ADOLF ,  REUSCHLING DIETER

IPC: A23L27/30 ,  B01J31/00 ,  B01J31/02 ,  B01J31/24 ,  C07B61/00 ,  C07C303/34 ,  C07C307/02 ,  C07C311/46 ,  C07D291/06

公开(公告)号：JPH03184948A

公开(公告)日：1991-08-12

申请号：JP33691390

申请日：1990-11-30

Applicant: HOECHST AG

Inventor： CLAUSS KARL ,  LINKIES ADOLF ,  REUSCHLING DIETER

IPC: A23L27/30 ,  B01J31/00 ,  B01J31/02 ,  B01J31/24 ,  C07B61/00 ,  C07C303/34 ,  C07C307/02 ,  C07C311/46 ,  C07D291/06

公开(公告)号：FI83638C

公开(公告)日：1991-08-12

申请号：FI851088

申请日：1985-03-19

Applicant: HOECHST AG

Inventor： LINKIES ADOLF ,  REUSCHLING DIETER

IPC: B01J27/00 ,  A23L27/30 ,  B01J27/232 ,  C07B61/00 ,  C07C67/00 ,  C07C301/00 ,  C07C303/36 ,  C07C307/00 ,  C07C307/02 ,  C07C311/00 ,  C07D291/06

公开(公告)号：FI83076B

公开(公告)日：1991-02-15

申请号：FI851104

申请日：1985-03-20

Applicant: HOECHST AG

Inventor： CLAUSS KARL ,  LINKIES ADOLF ,  REUSCHLING DIETER

IPC: A23L27/30 ,  B01J31/00 ,  B01J31/02 ,  B01J31/24 ,  C07B61/00 ,  C07C303/34 ,  C07C307/02 ,  C07C311/46 ,  C07D291/06

Abstract: 6-Methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide is prepared by (a) reacting, in an inert organic solvent, a salt of sulfamic acid, which is at least partially soluble therein, with at least approximately the equimolar amount of an acetoacetylating agent, in the presence of an amine or phosphine catalyst, and by cyclizing the acetoacetamide-N-sulfonate which is formed in this reaction, or the free sulfonic acid, (b) by the action of at least approximately the equimolar amount of SO3, where appropriate in an inert inorganic or organic solvent, to give 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide, which is produced in the form of the acid in this reaction; it is possible, if desired, to obtain from the acid form (c) the appropriate salts by neutralization with bases. The non-toxic salts - in particular the potassium salt - are valuable synthetic sweeteners.

公开(公告)号：FI81789C

公开(公告)日：1990-12-10

申请号：FI851103

申请日：1985-03-20

Applicant: HOECHST AG

Inventor： CLAUSS KARL ,  LINKIES ADOLF ,  REUSCHLING DIETER

IPC: A23L27/30 ,  C07D291/06

公开(公告)号：CA1273922A

公开(公告)日：1990-09-11

申请号：CA477144

申请日：1985-03-21

Applicant: HOECHST AG

Inventor： CLAUSS KARL ,  LINKIES ADOLF ,  REUSCHLING DIETER

IPC: A23L27/30 ,  C07D291/06

Abstract: 6-Methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2dioxide is prepared by reaction of acetoacetamide with at least approximately twice the molar amount of S03 per mole of acetoacetamide, if appropriate in an inert inorganic or organic solvent. Relevant salts can be obtained, using bases, from the product which results in the form of the acid. The non-toxic saLts, in particular the potassium salt, are valuable synthetic sweeteners.

公开(公告)号：FI81789B

公开(公告)日：1990-08-31

申请号：FI851103

申请日：1985-03-20

Applicant: HOECHST AG

Inventor： CLAUSS KARL ,  LINKIES ADOLF ,  REUSCHLING DIETER

IPC: A23L27/30 ,  C07D291/06

Abstract: 6-Methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide is prepared by reaction of acetoacetamide with at least approximately twice the molar amount of SO3 per mole of acetoacetamide, if appropriate in an inert inorganic or organic solvent. Relevant salts can be obtained, using bases, from the product which results in the form of the acid. The non-toxic salts, in particular the potassium salt, are valuable synthetic sweeteners.