公开(公告)号：NZ217322A

公开(公告)日：1990-02-26

申请号：NZ21732286

申请日：1986-08-22

Applicant: HOECHST AG

Inventor： LANG H-J ,  RACKUR G ,  ROSNER M ,  HERLING A W

IPC: A61K31/415 ,  A61K31/4184 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/454 ,  A61K31/47 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5355 ,  A61K31/54 ,  A61K31/541 ,  A61P1/04 ,  C07D235/02 ,  C07D235/28 ,  C07D319/00 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D491/04 ,  C07D491/056 ,  C07D413/12 ,  C07D417/12

Abstract: o-Toluidine derivatives of the formula I in which A denotes S, SO or SO2 and R , R , R , R , R , R , R , R , R , R and R represent hydrogen and/or defined substituents.

公开(公告)号：EG13165A

公开(公告)日：1980-10-31

申请号：EG17378

申请日：1978-03-15

Applicant: HOECHST AG

Inventor： RAETHER W ,  ROSNER M

IPC: A61K31/415 ,  A61K31/55 ,  C07D403/14 ,  C07D405/14

公开(公告)号：NZ217471A

公开(公告)日：1989-06-28

申请号：NZ21747186

申请日：1986-09-05

Applicant: HOECHST AG

Inventor： ROSNER M ,  RAETHER W

IPC: A23K1/16 ,  A61K31/53 ,  A61P31/00 ,  A61P33/02 ,  C07D253/06 ,  C07D253/075

Abstract: Compounds of the formula I (I) with n=1-3, R=H, Hal, CF3, alkyl, cycloalkyl, alkyloxy, alkylthio, alkylsulfinyl, alkylsulfonyl, benzylsulfinyl, benzylsulfonyl, nitro, cyano, amino, alkylamino, dialkylamino, piperidino, morpholino, pyrrolidinyl, 4-methyl-1-piperazinyl, acylamino or substituted phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl, benzoyl, benzoylamino or anilino, with R2=H, alkyl, cycloalkyl, optionally substituted benzyl, alkanoyl or benzoyl and R3=H, alkyl, cycloalkyl or optionally substituted benzyl, at least R2 or R3 not being H, are obtained by alkylation or acylation of a compound II (II) in which R1 is as defined above, with compounds R3X (X=leaving group) or R2Y (Y=leaving group), R2 and R3 being defined as indicated. Compounds I are coccidiostatics.

公开(公告)号：NZ206658A

公开(公告)日：1986-06-11

申请号：NZ20665883

申请日：1983-12-21

Applicant: HOECHST AG

Inventor： ROSNER M ,  LOEWE H ,  DUWEL D ,  KIRSCH R

IPC: A61K31/415 ,  A61K31/4184 ,  A61P33/10 ,  C07D235/32 ,  C07D235/02 ,  C07D235/00 ,  A01N43/52

Abstract: New phenylsulfonyloxybenzimidazolecarbamates of the formula are described, as are processes for their preparation. The new compounds have anthelmintic activity, including, in particular, against liver flukes.

公开(公告)号：NZ211387A

公开(公告)日：1988-07-28

申请号：NZ21138785

申请日：1985-03-11

Applicant: HOECHST AG

Inventor： ROSNER M ,  RAETHER W

IPC: C07D249/12 ,  A23K1/16 ,  A61K31/41 ,  A61K31/53 ,  A61P33/02 ,  C07D253/06 ,  C07D253/075 ,  C07D401/10 ,  C07D413/10 ,  C07D417/10

Abstract: Substituted 2-phenyl-hexahydro-1,2,4-triazine-3,5-diones of the formula (I) in which n is one, two or three and the individual substituents R are independently of one another (a) hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl, alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 6 carbon atoms, alkoxy, alkylthio, alkylsulfinyl or alkylsulfonyl each having 1 to 6 carbon atoms in the alkyl moiety, nitro, cyano, amino, alkylamino or dialkylamino each having 1 to 12 carbon atoms in the alkyl moiety, piperidino, morpholino, thiomorpholino, 1-pyrrolidinyl, 4-methyl-1-piperazinyl or acylamino having 1 to 6 carbon atoms in the acyl moiety, or (b) a phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl, benzoyl, benzoylamino or aniline radical which is in each case R(a)-substituted, and the alkali metal salts, alkaline earth metal salts or ammonium salts thereof, a process for their preparation, their use, veterinary drugs and a process for controlling protozoal diseases.

公开(公告)号：NZ207691A

公开(公告)日：1986-07-11

申请号：NZ20769184

申请日：1984-03-29

Applicant: HOECHST AG

Inventor： ROSNER M ,  HOCK F

IPC: A61K31/41 ,  A61K31/50 ,  A61P25/08 ,  A61P25/20 ,  C07D487/04 ,  C07D487/00

Abstract: For the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. Compounds of the formula see diagramm : EP0121490,P11,F1 and salts thereof with a physiologically acceptable acid, in which formula R**1 and R**2 are identical or different and represent hydrogen, alkyl groups having 1-6 carbon atoms, phenyl or chlorine, R**3 denotes linear or branched alkyl having 1-6 carbon atoms, cycloalkyl having 3-8 carbon atoms, phenylalkyl which has 1-4 carbon atoms in the alkyl part and is optionally monosubstituted, disubstituted or trisubstituted in the phenyl part by fluorine, chlorine, bromine, iodine, trifluoromethyl or alkyl having 1-4 carbon atoms, alkylcarbonyl having 1-6 carbon atoms in the alkyl part, cycloalkylcarbonyl having 5-7 carbon atoms in the cycloalkyl part, or benzoyl which is optionally monosubstituted, disubstituted or trisubstituted by fluorine, chlorine, bromine, iodine, trifluoromethyl or alkyl having 1-4 carbon atoms, or denotes Ar, and in which Ar represents phenyl, phenoxyphenyl, phenylthiophenyl, 2-thienyl or 2-furyl, these radicals being optionally monosubstituted or disubstituted by fluorine, chlorine, alkyl groups having 1-6 carbon atoms, cyano or trifluoromethyl, with the exception of compounds of the formula I in which R**1 and R**2 denote hydrogen, R**3 denotes phenyl and Ar denotes phenyl or 4-methylphenyl. For the Contracting State AT 1. A process for the preparation of compounds of the formula I see diagramm : EP0121490,P13,F1 and salts thereof with a physiologically acceptable acid, in which formula R**1 and R**2 are identical or different and represent hydrogen, alkyl groups having 1-6 carbon atoms, phenyl or chlorine, R**3 denotes linear or branched alkyl having 1-6 carbon atoms, cycloalkyl having 3-8 carbon atoms, phenylalkyl which has 1-4 carbon atoms in the alkyl part and is optionally monosubstituted, disubstituted or trisubstituted in the phenyl part by fluorine, chlorine, bromine, iodine, trifluoromethyl or alkyl having 1-4 carbon atoms, alkylcarbonyl having 1-6 carbon atoms in the alkyl part, cycloalkylcarbonyl having 5-7 carbon atoms in the cycloalkyl part, or benzoyl which is optionally monosubstituted, disubstituted or trisubstituted by fluorine, chlorine, bromine, iodine, trifluoromethyl or alkyl having 1-4 carbon atoms, or denotes Ar, and in which Ar represents phenyl, phenoxyphenyl, phenylthiophenyl, 2-thienyl or 2-furyl, these radicals being optionally monosubstituted or disubstituted by fluorine, chlorine, alkyl groups having 1-6 carbon atoms, cyano or trifluoromethyl, with the exception of compounds of the formula I in which R**1 and R**2 denote hydrogen, R**3 denotes phenyl and Ar denotes phenyl or 4-methylphenyl, which comprises a) cyclizing a compound of the formula II see diagramm : EP0121490,P13,F2 in which Ar, R**1, R**2 and R**3 have the meanings indicated for formula I and Z represents O or S, by heating, if appropriate with the addition of a condensation agent, to give a compound of the formula I, or b) by reacting a compound of the formula III see diagramm : EP0121490,P13,F3 in which R**6 denotes chlorine, bromine or methylthio and Ar, R**1 and R**2 have the meanings indicated for formula I, with an amine of the formule IV see diagramm : EP0121490,P14,F4 in which R**3 has the meaning indicated for formula I, or c) reacting, if appropriate with the addition of a condensation agent or catalyst, a compound of the formula V see diagramm : EP0121490,P14,F5 or one of its salts in which Ar, R**1 and R**2 have the meanings indicated for formula I, with a compound of the formula VI R**3-Y in which R**3 has the meaning indicated for formula I and Y represents a leaving group, such as, for example, fluorine, chlorine, bromine, iodine, see diagramm : EP0121490,P14,F6 or the tosylate radical, and, if appropriate, converting a compound thus obtained into a salt thereof by adding a physiologically acceptable acid.