公开(公告)号：CA1170271A

公开(公告)日：1984-07-03

申请号：CA368741

申请日：1981-01-16

Applicant: HOECHST AG

Inventor： SPIELMANN WERNER ,  SCHAEFFER GEORG

IPC: C07C59/52 ,  C07C51/00 ,  C07C51/377 ,  C07C67/00

Abstract: HOE 80/F 007 PROCESS FOR THE MANUFACTURE OF p-HYDROXYPHENYL- ACETIC ACID of the disclosure p-Hydroxyphenylacetic acid is prepared by reduction of p-hydroxymandelic acid with HI in the presence of red phosphorus. According to a preferred embodiment, the reaction is carried out in one vessel in which the mandelic acid is prepared in situ from phenol and glyoxylic acid.

公开(公告)号：CA1125779A

公开(公告)日：1982-06-15

申请号：CA340704

申请日：1979-11-27

Applicant: HOECHST AG

Inventor： SPIELMANN WERNER ,  SCHAEFFER GEORG

IPC: C07C45/45 ,  C07C45/75 ,  C07C49/00 ,  C07C69/76 ,  C07D307/46 ,  C07D333/16 ,  C07D333/22 ,  C07D307/12 ,  C07C45/00

Abstract: of the disclosure: Ketones are prepared by reacting carboxylic acid halides, in particular carboxylic acid chlorides, with aluminum-alkyl compounds, optionally in the presence of an aluminum trihalid?, in methylene chloride as the solvent, at a temperature between about 20 and about 100.degree.C, preferably between about 30 and about 60.degree.C, more preferably of about 40.degree.C - which latter is the reflux temperature of the methylene chloride -. When operating at a temperature above approximately 40.degree.C, overpressure is applied. The reaction mixture is worked up in usual manner, suitably by decomposition with water followed by distillation.

公开(公告)号：MX149164A

公开(公告)日：1983-09-08

申请号：MX18022779

申请日：1979-11-28

Applicant: HOECHST AG

Inventor： SPIELMANN WERNER ,  SCHAEFFER GEORG

IPC: C07C45/45 ,  C07C45/75 ,  C07C49/00 ,  C07C69/76 ,  C07D307/46 ,  C07D333/16 ,  C07D333/22 ,  C07C45/15 ,  C07C49/76

Abstract: Ketones are prepared by reacting carboxylic acid halides, in particular carboxylic acid chlorides, with aluminum-alkyl compounds, optionally in the presence of an aluminum trihalide, in methylene chloride as the solvent, at a temperature between about 20 DEG and about 100 DEG C., preferably between about 30 DEG and about 60 DEG C., more preferably of about 40 DEG C. which is the reflux temperature of the methylene chloride. When operating at a temperature above approximately 40 DEG C., pressure higher than atmospheric is applied. The reaction mixture is worked up in usual manner, suitably by decomposition with water followed by distillation.

公开(公告)号：CA1135276A

公开(公告)日：1982-11-09

申请号：CA363700

申请日：1980-10-31

Applicant: HOECHST AG

Inventor： SPIELMANN WERNER ,  SCHAEFFER GEORG

IPC: C07C69/614 ,  B01J23/00 ,  C07B61/00 ,  C07C51/00 ,  C07C51/377 ,  C07C57/32 ,  C07C57/58 ,  C07C59/52 ,  C07C59/64 ,  C07C67/00 ,  C07C69/73 ,  C07C69/76 ,  C07C227/00 ,  C07C227/16 ,  C07C229/42 ,  C07C231/00 ,  C07C231/12 ,  C07C235/42 ,  C07C59/11

Abstract: of the disclosure: Phenylacetic acid and the simple derivatives thereof are prepared by catalytic hydrogenation of mandelic acid and its appropriate derivatives in the presence of a noble metal catalyst in aqueous solution which is free from mineral acid, especially free from hydrochloric acid.

公开(公告)号：AU530755B2

公开(公告)日：1983-07-28

申请号：AU5320579

申请日：1979-11-27

Applicant: HOECHST AG

Inventor： SPIELMANN WERNER ,  SCHAEFFER GEORG

IPC: C07C45/45 ,  C07C45/75 ,  C07C49/00 ,  C07C69/76 ,  C07D307/46 ,  C07D333/16 ,  C07D333/22 ,  C07C45/15

Abstract: Ketones are prepared by reacting carboxylic acid halides, in particular carboxylic acid chlorides, with aluminum-alkyl compounds, optionally in the presence of an aluminum trihalide, in methylene chloride as the solvent, at a temperature between about 20 DEG and about 100 DEG C., preferably between about 30 DEG and about 60 DEG C., more preferably of about 40 DEG C. which is the reflux temperature of the methylene chloride. When operating at a temperature above approximately 40 DEG C., pressure higher than atmospheric is applied. The reaction mixture is worked up in usual manner, suitably by decomposition with water followed by distillation.

公开(公告)号：MX6763E

公开(公告)日：1986-06-27

申请号：MX926981

申请日：1981-01-16

Applicant: HOECHST AG

Inventor： SPIELMANN WERNER ,  SCHAEFFER GEORG

IPC: C07C51/00 ,  C07C59/52 ,  C07C51/377 ,  C07C67/00

Abstract: p-Hydroxyphenylacetic acid is prepared by reduction of p-hydroxymandelic acid with HI in the presence of red phosphorus. According to a preferred embodiment, the reaction is carried out in one vessel in which the mandelic acid is prepared in situ from phenol and glyoxylic acid.

公开(公告)号：AU5320579A

公开(公告)日：1980-05-29

申请号：AU5320579

申请日：1979-11-27

Applicant: HOECHST AG

Inventor： SPIELMANN WERNER ,  SCHAEFFER GEORG

IPC: C07C45/45 ,  C07C45/75 ,  C07C49/00 ,  C07C69/76 ,  C07D307/46 ,  C07D333/16 ,  C07D333/22 ,  C07C45/15

Abstract: Ketones are prepared by reacting carboxylic acid halides, in particular carboxylic acid chlorides, with aluminum-alkyl compounds, optionally in the presence of an aluminum trihalide, in methylene chloride as the solvent, at a temperature between about 20 DEG and about 100 DEG C., preferably between about 30 DEG and about 60 DEG C., more preferably of about 40 DEG C. which is the reflux temperature of the methylene chloride. When operating at a temperature above approximately 40 DEG C., pressure higher than atmospheric is applied. The reaction mixture is worked up in usual manner, suitably by decomposition with water followed by distillation.