公开(公告)号：US3843661A

公开(公告)日：1974-10-22

申请号：US25930072

申请日：1972-06-02

Applicant: HOECHST AG

Inventor： WEBER H ,  MUTH K ,  STACH K ,  AUMULLER W ,  WEYER R

IPC: C07D209/08 ,  C07D209/44 ,  C07D209/72 ,  C07D215/58 ,  C07D217/08 ,  C07D221/20 ,  C07D223/14 ,  C07D295/215 ,  C07D295/28 ,  C07D333/38 ,  C07D29/34

CPC classification number: C07D221/20 ,  C07D209/08 ,  C07D209/44 ,  C07D209/72 ,  C07D215/58 ,  C07D217/08 ,  C07D223/14 ,  C07D295/215 ,  C07D295/32 ,  C07D333/38

Abstract: Benzene-sulfonyl semicarbazides having hypoglycemic properties and corresponding to the general formula

WHEREIN R represents A. PHENYL WHICH MAY BE SUBSTITUTED ONCE OR TWICE BY SUBSTITUENTS OF THE GROUP LOWER ALKYL, ALKENYL, ALKOXY ALKENOXY, ALKOXYALKOXY, ACYL, HALOGEN, OR TRIFLUOROMETHYL, OR BY THE METHYLENE-DIOXY GROUP, B. THIENYL WHICH MAY BE SUBSTITUTED ONCE OR TWICE BY SUBSTITUENTS OF THE GROUP HALOGEN, LOWER ALKYL, ALKOXY, ALKENYLOXY, ALKOXYALKOXY, PHENALKOXY, OR ARYL, OR BY A POLYMETHYLENE CHAIN LINKED AT ITS TWO ENDS TO THE THIENYL GROUP, WHICH CHAIN CONTAINS FROM 3 TO 4 CARBON ATOMS; Y represents -CH2-CH2-, -CH2-CH-(CH3)- or -CH(CH3)-CH2; R1 represents A N-3-azaspiro-(5,5)-undecane AND SALTS THEREOF FORMED FROM PHARMACEUTICALLY ACCEPTABLE BASES.

公开(公告)号：US3847938A

公开(公告)日：1974-11-12

申请号：US25929972

申请日：1972-06-02

Applicant: HOECHST AG

Inventor： WEBER H ,  AUMUELLER W ,  WEYER R ,  MUTH K ,  STACH K

IPC: C07D209/08 ,  C07D209/44 ,  C07D209/72 ,  C07D215/58 ,  C07D217/08 ,  C07D221/20 ,  C07D223/14 ,  C07D295/215 ,  C07D295/28 ,  C07D333/38 ,  C07D27/48

CPC classification number: C07D221/20 ,  C07D209/08 ,  C07D209/44 ,  C07D209/72 ,  C07D215/58 ,  C07D217/08 ,  C07D223/14 ,  C07D295/215 ,  C07D295/32 ,  C07D333/38

Abstract: 1. A BENZENE-SULFONYL SEMICARBAZIDE OF THE FORMULA 1-(R-CO-NH-Y-),4-(R1-NH-CO-NH-SO2-)BENZENE WHEREIN R REPRESENTS (A) PHENYL WHICH MAY CARRY ONE OR TWO SUBSTITUENTS SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYL, LOWER ALKENYL, LOWER ALKOXY, LOWER ALKENOXY, LOWER ALKOXYALKOXY, ACETYL, HALOGEN, TRIFLUORO-METHYL, OR THE METHYLENE-DIOXY GROUP, (B) THIENYL WHICH MAY CARRY ONE OR TWO SUBSTITUENTS SELECTED FROM THE GROUP CONSISTING OF HALOGEN, LOWER ALKYL, LOWER ALKOXY LOWER ALKENYLOXY LOWER ALKOXYALKOXY, PHEN-LOWERALKOXY, OR POLYMETHYLENE CHAIN CONTAINING FROM 3 TO 4 CARBON ATOMS, LINKED AT ITS TWO ENDS TO THE THIENYL GROUP, Y REPRESENTS -CH2-CH2-, -CH2-CH-(CH3)OR -CH-(CH3)-CH2-, R1 REPRESENTS 4,7-ENDOALKYLENE-HEXAHYDRO-ISO-INDOLINE OR 4,7-ENDOALKYLENE-TETRAHYDRO-ISO-INDOLINE, HAVING 1 TO 2 CARBON ATOMS IN THE ENDOALKYLENE GROUP, IN THE CASE OF TETRAHYDROCOMPOUNDS THE DOUBLE LINKAGE DEING IN 5,6-POSITION; 4,7-ENDOCYCLOBUTYLENE-HEXAHYDROISO-INDOLINE; 4,7-ENDOCYCLOBUTYLENE-&5-TETRAHYDRO-ISOINDOLINE; 4,7-ENDOCYCLOBUTYLENE-&5 -TETRAHYDRO-SIOINDOLINE; OR 4,7-ENDOCYCLOPROPYLENE-HEXAHYDRO-ISOINDOLINE; AND SALTS THEREOF FORMED FROM PHARMACEUTICALLY ACCEPTABLE BASES.

公开(公告)号：US3709908A

公开(公告)日：1973-01-09

申请号：US3709908D

申请日：1970-10-07

Applicant: HOECHST AG

Inventor： WEBER H ,  MUTH K ,  STACH K ,  WEYER R ,  AUMULLER W

IPC: C07D209/08 ,  C07D215/08 ,  C07D317/66 ,  C07D27/38 ,  C07D33/10

CPC classification number: C07D317/66 ,  C07D209/08 ,  C07D215/08

Abstract: BENZENESULFONYL UREA COMPOUNDS THAT ARE EFFECTIVE AS ORAL ANTIDIABETIC AGENTS ARE DISCLOSED TO HAVE THE FORMULA

(4-(X-N(-X1)-CO-NH-Y-)PHENYL)-SO2-NH-CO-NH-R

WHEREIN R IS (A) ALKYL OR ALKENYL OF 3-6 CARBON ATOMS, (B) ENDOALKYLENE-CYCLOHEXYL, ENDOALKYLENE-CYCLOHEXENYL, ENDOALKYLENE-CYCLOHEXYLMETHYL OR ENDOALKYLENE-CYCLOHEXENYLMETHYL OF 1-2 ENDOALKYLENE CARBON ATOMS, (C) BENZYL, PHENYLETHYL, (D) CYCLOHEXYL METHYL, (E) LOWER ALKYL CYCLOHEXYL OR DIALKYL CYCLOHEXYL, METHYL CYCLOPENTYL, (F) CYCLOALKYL OF 5-8 CARBON ATOMS IN THE RING (G) CYCLOHEXENYL, CYCLOHEXENYL-METHYL, METHYLCYCLOHEXENYL, OR (H) NORTRICYCLYL,

X-N(-X1)-

IS INDOLINO OR TETRAHYDROQUINOLINO, AND Y IS ALKYLENE OF 1 TO 3 CARBON ATOMS.

公开(公告)号：FI46378B

公开(公告)日：1972-11-30

申请号：FI318766

申请日：1966-12-01

Applicant: HOECHST AG

Inventor： GALL R ,  STACH K ,  SCHMID A

IPC: C07D307/52 ,  C07D5/16 ,  C07D31/34 ,  C07D63/12

公开(公告)号：DK130679B

公开(公告)日：1975-03-24

申请号：DK253167

申请日：1967-05-12

Applicant: HOECHST AG

Inventor： STACH K

IPC: A61K31/64 ,  C07D209/08 ,  C07D215/08 ,  C07D295/215 ,  C07D317/66 ,  C07C143/78

公开(公告)号：FI45962B

公开(公告)日：1972-07-31

申请号：FI138867

申请日：1967-05-16

Applicant: HOECHST AG

Inventor： WEYER R ,  MUTH K ,  STACH K ,  AUMUELLER W ,  WEBER H

IPC: A61K31/64 ,  C07D209/08 ,  C07D215/08 ,  C07D295/215 ,  C07D317/66 ,  C07C143/78

公开(公告)号：NO122417B

公开(公告)日：1971-06-28

申请号：NO16815067

申请日：1967-05-13

Applicant: HOECHST AG

Inventor： WEYER R ,  AUMUELLER W ,  STACH K ,  WEBER H ,  MUTH K

IPC: A61K31/64 ,  C07D209/08 ,  C07D215/08 ,  C07D295/215 ,  C07D317/66

公开(公告)号：SE319763B

公开(公告)日：1970-01-26

申请号：SE1573365

申请日：1965-12-06

Applicant: HOECHST AG

Inventor： WEBER H ,  WEYER R ,  AUMUELLER W ,  MUTH K ,  STACH K

IPC: A61K31/64 ,  C07C67/00 ,  C07C301/00 ,  C07C303/36 ,  C07C311/58 ,  C07D295/215 ,  C07C143/833

公开(公告)号：DK124256B

公开(公告)日：1972-10-02

申请号：DK630365

申请日：1965-12-08

Applicant: HOECHST AG

Inventor： STACH K

IPC: A61K31/64 ,  C07C67/00 ,  C07C301/00 ,  C07C303/36 ,  C07C311/58 ,  C07D295/215 ,  C07C143/78

公开(公告)号：DK130679C

公开(公告)日：1975-08-25

申请号：DK253167

申请日：1967-05-12

Applicant: HOECHST AG

Inventor： STACH K

IPC: A61K31/64 ,  C07D209/08 ,  C07D215/08 ,  C07D295/215 ,  C07D317/66 ,  C07C143/78