公开(公告)号：SK58596A3

公开(公告)日：1997-05-07

申请号：SK58596

申请日：1994-10-24

Applicant: HOECHST AG

Inventor： ZOLLER GERHARD ,  KLINGLER OTMAR ,  JABLONKA BERND ,  JUST MELITTA ,  BREIPOHL GERHARD ,  KNOLLE JOCHEN ,  KOENIG WOLFGANG ,  STILZ HANS-ULRICH

IPC: A61K31/415 ,  A61K31/4166 ,  A61K31/52 ,  A61K31/522 ,  A61K38/00 ,  A61P7/02 ,  A61P35/00 ,  C07D233/74 ,  C07D233/76 ,  C07D277/34 ,  C07D401/12 ,  C07D473/18 ,  C07K5/00 ,  C07K5/02 ,  C07K5/078 ,  C07K5/097 ,  C07D207/40 ,  C07D233/30 ,  C07D263/18 ,  C07D277/14 ,  A61K31/41

Abstract: 5-Membered ring heterocycle of the formula I,in which D includes a COOR15, CON(CH3)R15 or CONHR15 radical and R15 includes a 6-24 member bicyclic or tricyclic radical, compositions, preparation and use as inhibitors of thrombocyte aggregation, metastasization of carcinoma cells, binding of osteoclasts to bone surfaces and for the treatment of tromboses.

公开(公告)号：AU7939794A

公开(公告)日：1995-06-06

申请号：AU7939794

申请日：1994-10-24

Applicant: HOECHST AG

Inventor： ZOLLER GERHARD ,  KLINGLER OTMAR ,  JABLONKA BERND ,  JUST MELITTA ,  BREIPOHL GERHARD ,  KNOLLE JOCHEN ,  KONIG WOLFGANG ,  STILZ HANS-ULRICH

IPC: A61K31/415 ,  A61K31/4166 ,  A61K31/52 ,  A61K31/522 ,  A61K38/00 ,  A61P7/02 ,  A61P35/00 ,  C07D233/74 ,  C07D233/76 ,  C07D277/34 ,  C07D401/12 ,  C07D473/18 ,  C07K5/00 ,  C07K5/02 ,  C07K5/078 ,  C07K5/097

Abstract: 5-Membered ring heterocycle of the formula I,in which D includes a COOR15, CON(CH3)R15 or CONHR15 radical and R15 includes a 6-24 member bicyclic or tricyclic radical, compositions, preparation and use as inhibitors of thrombocyte aggregation, metastasization of carcinoma cells, binding of osteoclasts to bone surfaces and for the treatment of tromboses.

公开(公告)号：NO317241B1

公开(公告)日：2004-09-27

申请号：NO975244

申请日：1997-11-14

Applicant: HOECHST AG

Inventor： KNOLLE JOCHEN ,  WEHNER VOLKMAR ,  HUELS CHRISTOPH ,  STILZ HANS-ULRICH ,  BARTNIK ECKART

IPC: A61K31/415 ,  A61K31/4166 ,  A61K31/4178 ,  A61K31/421 ,  A61K31/426 ,  C07D233/00 ,  A61K38/00 ,  A61K38/06 ,  A61K38/07 ,  A61K38/39 ,  A61P3/08 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P19/02 ,  A61P29/00 ,  A61P33/02 ,  A61P35/00 ,  A61P37/00 ,  A61P37/08 ,  A61P43/00 ,  C07D233/32 ,  C07D233/72 ,  C07D233/74 ,  C07D233/76 ,  C07D233/86 ,  C07D257/00 ,  C07D403/12 ,  C07D405/12 ,  C07K5/02 ,  C07K5/023 ,  C07K5/078 ,  C07K5/08 ,  C07K5/097 ,  C07K5/10 ,  C07K5/117 ,  C07K7/06 ,  C07K14/78 ,  A61K38/05 ,  C07D233/40 ,  C07K5/06 ,  A61K31/395

Abstract: Use of N-substituted pyrrolidone, imidazolidinone, oxazolidinone or thiazolidinone derivatives of formula (I), in all stereoisomer (or mixture) forms, or their salts for inhibiting the adhesion and/or migration of leukocytes or inhibiting VLA-4 receptors is new. W = R1-A-CR13 or R1A-CH=C; Y = CO, CS or CH2; Z = O, S or CH2 etc.; A = 1-6C alkylene, 3-7C cycloalkylene, (1-6C) alkylene-phenylene, or the divalent residue of a 5- or 6-membered ring containing 1 or 2 N (optionally substituted); B = 1-6C alkylene (optionally substituted), 2-6C alkenylene, phenylene, phenylene-(1-3C) alkyl or (1-3C) alkylene-phenylene; D = CR2R3, NR3 or CH=CR3; E = tetrazolyl, SO3H etc.; R = H, alkyl, 3-8C cycloalkyl, Ar or Ar-alkyl ; R1 = X-NH-C(=NH)-(CH2)p or X1-NH-(CH2)p; p = 0-3; X = H, 1-6C alkyl, (1-6C) alkylcarbonyl, Ar-(1-6C) alkoxycarbonyl, CN, OH, etc.; X1 = X etc.; R2 = H, alkyl, Ar, Ar-alkyl or 3-8C cycloalkyl; R3 = H, alkyl, Ar, alkenyl, alkynyl, pyridyl etc.; R13 = H, 1-6C alkyl, Ar-alkyl or 3-8C cycloalkyl; b, c, d, f = 0 or 1, but not all 0; e, g, h= 0-6; Ar = optionally substituted 6-14C aryl; unless specified otherwise alkyl moieties have 1-8C, alkenyl or alkynyl moieties 2-8C, cycloalkyl moieties 3-12C and bi- or tri-cycloalkyl moieties 6-12C.

公开(公告)号：CY2385B1

公开(公告)日：2004-06-04

申请号：CY0300083

申请日：2003-11-11

Applicant: HOECHST AG

Inventor： ZOLLER GERHARD ,  KLINGLER OTMAR ,  JABLONKA BERND ,  JUST MELITTA ,  BREIPOHL GERHARD ,  KNOLLE JOCHEN ,  KOENIG WOLFGANG ,  STILZ HANS-ULRICH

IPC: A61K31/415 ,  A61K31/4166 ,  A61K31/52 ,  A61K31/522 ,  A61K38/00 ,  A61P7/02 ,  A61P35/00 ,  C07D233/74 ,  C07D233/76 ,  C07D277/34 ,  C07D401/12 ,  C07D473/18 ,  C07K5/00 ,  C07K5/02 ,  C07K5/078 ,  C07K5/097

Abstract: 5-Membered ring heterocycle of the formula I,in which D includes a COOR15, CON(CH3)R15 or CONHR15 radical and R15 includes a 6-24 member bicyclic or tricyclic radical, compositions, preparation and use as inhibitors of thrombocyte aggregation, metastasization of carcinoma cells, binding of osteoclasts to bone surfaces and for the treatment of tromboses.

公开(公告)号：FI113265B

公开(公告)日：2004-03-31

申请号：FI962043

申请日：1996-05-14

Applicant: HOECHST AG

Inventor： ZOLLER GERHARD ,  KLINGLER OTMAR ,  JABLONKA BERND ,  JUST MELITTA ,  BREIPOHL GERHARD ,  KNOLLE JOCHEN ,  KOENIG WOLFGANG ,  STILZ HANS-ULRICH

IPC: A61K31/415 ,  A61K31/4166 ,  A61K31/52 ,  A61K31/522 ,  A61K38/00 ,  A61P7/02 ,  A61P35/00 ,  C07D233/74 ,  C07D233/76 ,  C07D277/34 ,  C07D401/12 ,  C07D473/18 ,  C07K5/00 ,  C07K5/02 ,  C07K5/078 ,  C07K5/097

Abstract: 5-Membered ring heterocycle of the formula I,in which D includes a COOR15, CON(CH3)R15 or CONHR15 radical and R15 includes a 6-24 member bicyclic or tricyclic radical, compositions, preparation and use as inhibitors of thrombocyte aggregation, metastasization of carcinoma cells, binding of osteoclasts to bone surfaces and for the treatment of tromboses.

公开(公告)号：DE59410120D1

公开(公告)日：2002-06-20

申请号：DE59410120

申请日：1994-10-24

Applicant: HOECHST AG

Inventor： ZOLLER GERHARD ,  KLINGLER OTMAR ,  JABLONKA BERND ,  JUST MELITTA ,  BREIPOHL GERHARD ,  KNOLLE JOCHEN ,  KOENIG WOLFGANG ,  STILZ HANS-ULRICH

IPC: A61K31/415 ,  A61K31/4166 ,  A61K31/52 ,  A61K31/522 ,  A61K38/00 ,  A61P7/02 ,  A61P35/00 ,  C07D233/74 ,  C07D233/76 ,  C07D277/34 ,  C07D401/12 ,  C07D473/18 ,  C07K5/00 ,  C07K5/02 ,  C07K5/078 ,  C07K5/097

Abstract: 5-Membered ring heterocycle of the formula I,in which D includes a COOR15, CON(CH3)R15 or CONHR15 radical and R15 includes a 6-24 member bicyclic or tricyclic radical, compositions, preparation and use as inhibitors of thrombocyte aggregation, metastasization of carcinoma cells, binding of osteoclasts to bone surfaces and for the treatment of tromboses.

公开(公告)号：AU679509B2

公开(公告)日：1997-07-03

申请号：AU6375494

申请日：1994-03-09

Applicant: HOECHST AG

Inventor： KLINGLER OTMAR ,  JABLONKA BERND ,  JUST MELITTA ,  ZOLLER GERHARD ,  BREIPOHL GERHARD ,  KNOLLE JOCHEN ,  KONIG WOLFGANG ,  STILZ HANS-ULRICH

IPC: C07D215/54 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/215 ,  A61K31/445 ,  A61K31/47 ,  A61K38/00 ,  A61K38/04 ,  A61P7/02 ,  A61P35/00 ,  A61P43/00 ,  C07C275/40 ,  C07C275/42 ,  C07C309/13 ,  C07C311/31 ,  C07C335/06 ,  C07D211/62 ,  C07D263/32 ,  C07D453/02 ,  C07D471/08 ,  C07K5/06 ,  C07K5/072 ,  C07K5/08 ,  C07K5/083 ,  C07K5/097 ,  C07K5/02 ,  C07C311/55 ,  A61K37/02

Abstract: PCT No. PCT/EP94/00713 Sec. 371 Date Jan. 17, 1996 Sec. 102(e) Date Jan. 17, 1996 PCT Filed Mar. 9, 1994 PCT Pub. No. WO94/22907 PCT Pub. Date Oct. 13, 1994Urea derivates are disclosed having the formula (I). (I) in which A, B, W, Z, R, R1, R2, R3 and r have the meaning given in the description, as well as a process for preparing the same and their use as inhibitors of thrombocyte aggregation, carcinom cell metastasis and osteoclast binding to bone surface.

公开(公告)号：HU9502792D0

公开(公告)日：1995-11-28

申请号：HU9502792

申请日：1994-03-09

Applicant: HOECHST AG

Inventor： JUST MELITTA ,  JABLONKA BERND ,  ZOLLER GERHARD ,  KNOLLE JOCHEN ,  KLINGLER OTMAR ,  BREIPOHL GERHARD ,  KOENIG WOLFGANG ,  STILZ HANS-ULRICH

IPC: C07D215/54 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/215 ,  A61K31/445 ,  A61K31/47 ,  A61K38/00 ,  A61K38/04 ,  A61P7/02 ,  A61P35/00 ,  A61P43/00 ,  C07C275/40 ,  C07C275/42 ,  C07C309/13 ,  C07C311/31 ,  C07C335/06 ,  C07D211/62 ,  C07D263/32 ,  C07D453/02 ,  C07D471/08 ,  C07K5/06 ,  C07K5/072 ,  C07K5/08 ,  C07K5/083 ,  C07K5/097

Abstract: PCT No. PCT/EP94/00713 Sec. 371 Date Jan. 17, 1996 Sec. 102(e) Date Jan. 17, 1996 PCT Filed Mar. 9, 1994 PCT Pub. No. WO94/22907 PCT Pub. Date Oct. 13, 1994Urea derivates are disclosed having the formula (I). (I) in which A, B, W, Z, R, R1, R2, R3 and r have the meaning given in the description, as well as a process for preparing the same and their use as inhibitors of thrombocyte aggregation, carcinom cell metastasis and osteoclast binding to bone surface.

公开(公告)号：SK284471B6

公开(公告)日：2005-04-01

申请号：SK58596

申请日：1994-10-24

Applicant: HOECHST AG

Inventor： ZOLLER GERHARD ,  KLINGLER OTMAR ,  JABLONKA BERND ,  JUST MELITTA ,  BREIPOHL GERHARD ,  KNOLLE JOCHEN ,  KONIG WOLFGANG ,  STILZ HANS-ULRICH

IPC: A61K31/415 ,  A61K31/4166 ,  A61K31/52 ,  A61K31/522 ,  A61K38/00 ,  A61P7/02 ,  A61P35/00 ,  C07D233/74 ,  C07D233/76 ,  C07D277/34 ,  C07D401/12 ,  C07D473/18 ,  C07K5/00 ,  C07K5/02 ,  C07K5/078 ,  C07K5/097

Abstract: Described are substituted 5-membered ring heterocycles of the formula (I) and pharmaceutically acceptable salts thereof, method for preparation thereof and method for preparation of pharmaceutical compositions containing them, their use in medicine as inhibitors of thrombocyte aggregation, metastasizing of carcinoma cells and for binding of osteoclasts to bone surfaces.

公开(公告)号：AT167483T

公开(公告)日：1998-07-15

申请号：AT94911129

申请日：1994-03-09

Applicant: HOECHST AG

Inventor： KLINGLER OTMAR ,  JABLONKA BERND ,  JUST MELITTA ,  ZOLLER GERHARD ,  BREIPOHL GERHARD ,  KNOLLE JOCHEN ,  KOENIG WOLFGANG ,  STILZ HANS-ULRICH

IPC: C07D215/54 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/215 ,  A61K31/445 ,  A61K31/47 ,  A61K38/00 ,  A61K38/04 ,  A61P7/02 ,  A61P35/00 ,  A61P43/00 ,  C07C275/40 ,  C07C275/42 ,  C07C309/13 ,  C07C311/31 ,  C07C335/06 ,  C07D211/62 ,  C07D263/32 ,  C07D453/02 ,  C07D471/08 ,  C07K5/06 ,  C07K5/072 ,  C07K5/08 ,  C07K5/083 ,  C07K5/097

Abstract: PCT No. PCT/EP94/00713 Sec. 371 Date Jan. 17, 1996 Sec. 102(e) Date Jan. 17, 1996 PCT Filed Mar. 9, 1994 PCT Pub. No. WO94/22907 PCT Pub. Date Oct. 13, 1994Urea derivates are disclosed having the formula (I). (I) in which A, B, W, Z, R, R1, R2, R3 and r have the meaning given in the description, as well as a process for preparing the same and their use as inhibitors of thrombocyte aggregation, carcinom cell metastasis and osteoclast binding to bone surface.