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    New chemiluminescent 9-carboxy-acridinium cpds.
    6.
    发明专利
    New chemiluminescent 9-carboxy-acridinium cpds. 未知

    公开(公告)号：DE3645292C2

    公开(公告)日：1997-12-11

    申请号：DE3645292

    申请日：1986-08-22

    Applicant: HOECHST AG

    Inventor： MOLZ PETER DR ,  SKRZIPCZYK HEINZ JUERGEN DR ,  LUEBBERS HENNING DR ,  STRECKER HELMUT DR ,  SCHNORR GERD DR ,  KINKEL TONIO DR

    IPC: C07D219/04 ,  C07D401/12 ,  C09K11/06 ,  G01N33/532 ,  G01N33/533 ,  G01N33/543 ,  G01N33/58 ,  G01N33/68 ,  C09K11/07

    Abstract: (A) Chemiluminescent 9-carboxy-acridinium derivs. of formula (I) are new, where R1 = H, 1-10C alkyl, alkenyl or alkynyl, benzyl or aryl; R2, R3 = H, 1-4C alkyl, opt. substd. amino, COOH, alkoxy, CN, NO2 or halogen; R4 = residue in which a sulphonamide group is linked via the N-atom with the carbonyl group, or a thio residue of the formula -S-X-R5; X = opt. branched aliphatic or azomatic group, opt. contg. a hetero atom; R5 = reactive group capable of reacting under mild conditions selectively with amino, carboxy, thiol or other functional groups in substances of biological interest; A = anion not adversely affecting the chemiluminescence. (B) Luminescent cpds. in which a cpd. (I) is bound directly or via a bridging molecule to a protein, polypeptide or other biologically interesting substance to form a stable, immunologically active complex are new and claimed. (C) Luminescence immunoassays for the determination of an antigenic substance in a liquid specimen in which at least one immunologically active component is immoblised on a solid phase in a competitive or sandwich process and in which the tracer is a luminescent cpd. as defined under (B) are new.

    8.
    发明专利
    未知

    公开(公告)号：DE3779704D1

    公开(公告)日：1992-07-16

    申请号：DE3779704

    申请日：1987-08-01

    Applicant: HOECHST AG

    Inventor： SIMONS GUIDO DR ,  STRECKER HELMUT DR ,  MOLZ PETER DR ,  SCHNORR GERD DR ,  SKRZIPCZYK HEINZ JUERGEN DR ,  WISSMANN HANS DR

    IPC: G01N33/53 ,  G01N33/00 ,  G01N33/536 ,  G01N33/543 ,  G01N33/577 ,  G01N33/60 ,  G01N33/74 ,  G01N33/78 ,  G01N33/82

    Abstract: Determn. of the concn. of the free portion of an active ingredient (I) in a biological fluid in presence of its natural binder (II), the bound and free fractions of (I) being in equilibrium, comprises (1) treating the test sample with unlabelled antibody (Ab); (2) sepg. sample and Ab; (3) incubating Ab with a labelled, cross-reactive tracer (T), and (4) measuring amt. of T which is bound or unbound, and from this calculating the concn. of free (I). The novelty is that the amt. of Ab and/or its affinity to (I) is such that it does not significantly alter the equilibrium between free and bound forms, while T has a significantly higher or lower affinity for Ab than (I) itself. Also new is a test kit for the process. Specifically, Ab can be monoclonal or polyclonal, and T is labelled with a radioactive atom; fluoroescent or chemiluminescent gp.; enzyme or chromophore.

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