公开(公告)号：CA2019315A1

公开(公告)日：1990-12-20

申请号：CA2019315

申请日：1990-06-19

Applicant: HOECHST AG

Inventor： HEDTMANN UDO ,  FEHLHABER HANS-WOLFRAM ,  SUKATSCH DIETER-ANDREAS ,  KRAEMER HANS PETER ,  HOFFMANN DIETER

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07H15/252 ,  C12P19/56 ,  C12R1/00 ,  A61K31/65

Abstract: of the disclosure: Novel anthracycline derivatives, a process for the preparation thereof and the use thereof as a pharmaceutical The present invention relates to anthracycline derivatives of the formula I (I) in which R1 is the sugar residue Roa or the combination of sugars Roa-Rod-Rod and R2 is the sugar residue Roa, Roa being rhodosamine of the formula II (II) and Roa-Rod-Rod being rhodosamine-rhodinose-rhodinose of the formula III (III) and the pharmacologically acceptable salts thereof, and a microbiological process for the preparation thereof. The compounds have cytostatic activity and can therefore be used as pharmaceuticals.

公开(公告)号：PT94406A

公开(公告)日：1991-03-20

申请号：PT9440690

申请日：1990-06-19

Applicant: HOECHST AG

Inventor： HOFFMANN DIETER ,  KRAEMER HANS PETER ,  FEHLHABER HANS-WOLFRAM ,  HEDTMANN UDO ,  SUKATSCH DIETER-ANDREAS

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07H15/252 ,  C12P19/56 ,  C12R1/00

Abstract: The present invention relates to anthracycline derivatives of the formula I in which R is the sugar residue Roa or the sugar combination Roa-Rod-Rod and R is the sugar residue Roa, where Roa represents rhodosamine of the formula II and Roa-Rod-Rod represents rhodosamine-rhodinose-rhodinose of the formula III and to the pharmacologically acceptable salts thereof and to a microbiological process for the preparation thereof. The compounds have cytostatic activity and can therefore be used as medicaments.

公开(公告)号：AU5761690A

公开(公告)日：1991-01-03

申请号：AU5761690

申请日：1990-06-19

Applicant: HOECHST AG

Inventor： HEDTMANN UDO ,  FEHLHABER HANS-WOLFRAM ,  SUKATSCH DIETER-ANDREAS ,  KRAEMER HANS PETER ,  HOFFMANN DIETER

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07H15/252 ,  C12P19/56 ,  C12R1/00 ,  C07H17/04

Abstract: The present invention relates to anthracycline derivatives of the formula I in which R is the sugar residue Roa or the sugar combination Roa-Rod-Rod and R is the sugar residue Roa, where Roa represents rhodosamine of the formula II and Roa-Rod-Rod represents rhodosamine-rhodinose-rhodinose of the formula III and to the pharmacologically acceptable salts thereof and to a microbiological process for the preparation thereof. The compounds have cytostatic activity and can therefore be used as medicaments.