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公开(公告)号：US3925438A
公开(公告)日：1975-12-09
申请号：US48524274
申请日：1974-07-02
Applicant: HOECHST AG
Inventor： BRECHT HEINZ , HOFFMANN DIETER
IPC: C07C311/53 , C07C67/00 , C07C301/00 , C07C303/00 , C07C303/26 , C08G65/334 , D06M13/425 , D06M15/53 , C07C143/00
CPC classification number: D06M13/425 , C08G65/3348 , D06M15/53 , Y10S516/03
Abstract: Polyglycol esters of fluoroalkylurethane-N-sulfonic acids are obtained by reacting fluoroalkanols or oxethylates thereof with chlorosulfonyl isocyanate and acylating with the so-obtained sulfochloride a polyglycol. The products are thermo-labile emulsifiers.
Abstract translation: 氟代烷基氨基甲酸酯-N-磺酸的聚二醇酯是通过氟代烷醇或其氧基乙酸酯与异氰酸氯磺酰酯反应获得的，并用如此得到的磺酰氯进行酰化聚乙二醇。 该产品是热稳定乳化剂。
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公开(公告)号：AT193326T
公开(公告)日：2000-06-15
申请号：AT92102197
申请日：1992-02-10
Applicant: HOECHST AG
Inventor： SEEMANN GERHARD , BOSSLET KLAUS , CZECH JOERG , KOLAR CENEK , HOFFMANN DIETER , SEDLACEK HANS-HARALD
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公开(公告)号：IE911369A1
公开(公告)日：1991-11-06
申请号：IE136991
申请日：1991-04-24
Applicant: HOECHST AG
Inventor： KRONE VOLKER , MAGERSTAEDT MICHAEL , WALCH AXEL , GROENER ALBRECHT , HOFFMANN DIETER
IPC: A61K9/107 , A61K9/14 , A61K9/16 , A61K9/50 , A61K38/00 , A61K39/00 , A61K45/00 , A61K47/36 , A61K47/42 , A61K49/00 , A61K49/08 , A61K49/22 , A61P35/00 , A61P43/00 , G09B23/28 , A61K31/71 , A61K37/02 , A61K39/205
Abstract: The invention relates to a pharmacological product containing a polyelectrolyte complex, in particular a polyacid with a median particle size of less than 15 mu m and an active substance, which includes active peptides, proteins, enzymes, enzyme inhibitors, antigens, cytostatics, antiinflammatory agents, antibiotics and vaccines. The said product ensures that the active substance is converted in a non-damaging manner into a form which can be administered. In addition, there are beneficial effects on the biodistribution, bioavailability and absorption of the pharmaceutical composition.
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公开(公告)号：CA2041093A1
公开(公告)日：1991-10-26
申请号：CA2041093
申请日：1991-04-24
Applicant: HOECHST AG
Inventor： KRONE VOLKER , MAGERSTADT MICHAEL , WALCH AXEL , GRONER ALBRECHT , HOFFMANN DIETER
IPC: A61K9/107 , A61K9/14 , A61K9/16 , A61K9/50 , A61K38/00 , A61K39/00 , A61K45/00 , A61K47/36 , A61K47/42 , A61K49/00 , A61K49/08 , A61K49/22 , A61P35/00 , A61P43/00 , G09B23/28
Abstract: HOE 90/F 126K of the disclosure A pharmacological composition containing polyelectrolyte complexes in microparticulate form and at least one active substance. The invention relates to a pharmacological composition containing a polyelectrolyte complex, in particular a polyacid with an average particle size of less than 15 .mu.m and an active substance, among which are active peptides, proteins, enzymes, enzyme inhibitors, antigens, cytostatics, antiinflammatory agents, antibiotics and vaccines. The said composition ensures that the active substance is converted in a non-deleterious manner into a form which can be administered. In addition, the biodistribution, bioavailablility and absorption of the pharmaceutical are beneficially affected.
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公开(公告)号：CA2009695A1
公开(公告)日：1990-08-11
申请号：CA2009695
申请日：1990-02-09
Applicant: HOECHST AG
Inventor： BADER HUBERT , MAGERSTADT MICHAEL , SCHLINGMANN MERTEN , WALCH AXEL , GRONAU THOMAS , HOFFMANN DIETER , KRAEMER HANS-PETER , SEDLACEK HANS-HARALD
IPC: C07D475/04 , A61K9/18 , A61K31/505 , A61K31/785 , A61K47/48 , A61P35/00 , C08G69/48
Abstract: Polymer-bound methotrexate, a process for its preparation and its use The crosslinking of the carboxyl groups of methotrexate or analogs with hydroxyl groups of water-soluble, biocompatible polymers results in a pro-drug form of the active substance with good relevant properties for human antitumor therapy.
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Patent Agency Ranking
公开(公告)号：CA981279A
公开(公告)日：1976-01-06
申请号：CA143622
申请日：1972-06-01
Applicant: HOECHST AG
Inventor： STACH HANS , HOFFMANN DIETER , BRECHT HEINZ
Abstract: 1391618 Perfluorocarboxylic acid derivatives HOECHST AG 2 June 1972 [2 June 1971] 25903/72 Heading C2C [Also in Division B1] Novel perfluorocarboxylic acid derivatives of formula RfCO.NH.(CH 2 ) 3 .Y where Rf is an unbranched C 6 -C 10 perfluoroalkyl group and Y is a group of formulae -N[(CH 2 CH 2 O) n H] 2 , [(CH 2 ) q COO - ] or where R is C 1 -C 4 alkyl, X- is a halogen, sulphate or methosulphate anion, n is 1-5 and q is 1 or 2, are prepared by reacting an alkyl perfluoroalkanoate of formula RfCOOR where R is alkyl, with N,N-di-#-hydroxyethylpropylenediamine followed by optional etherification, esterification, or quaternization. The novel derivatives are used as melting and dispersing agents and as emulsifiers.
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公开(公告)号：CA2041093C
公开(公告)日：2004-08-03
申请号：CA2041093
申请日：1991-04-24
Applicant: HOECHST AG
Inventor： KRONE VOLKER , MAGERSTADT MICHAEL , WALCH AXEL , GRONER ALBRECHT , HOFFMANN DIETER
IPC: A61K9/107 , A61K9/14 , A61K9/16 , A61K9/50 , A61K38/00 , A61K39/00 , A61K45/00 , A61K47/36 , A61K47/42 , A61K49/00 , A61K49/08 , A61K49/22 , A61P35/00 , A61P43/00 , G09B23/28
Abstract: A pharmacological composition containing polyelectrolyte complexes in microparticulate form and at least one active substance. The invention relates to a pharmacological composition containing a polyelectrolyte complex, in particular a polyacid with an average particle size of less than 15 .mu.m and an active substance, among which are active peptides, proteins, enzymes, enzyme inhibitors, antigens, cytostatics, antiinflammatory agents, antibiotics and vaccines. The said composition ensures that the active substance is converted in a non-deleterious manner into a form which can be administered. In addition, the biodistribution, bioavailablility and absorption of the pharmaceutical are beneficially affected.
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公开(公告)号：PT648503E
公开(公告)日：2000-11-30
申请号：PT94114195
申请日：1994-09-09
Applicant: HOECHST AG , HOECHST HOUDE S A LAB
Inventor： HOFFMANN DIETER , MONNERET CLAUDE , FLORENT JEAN-CLAUDE , GESSON JEAN-PIERRE , CZECH JORG , KOCH MICHEL , TILLEQUIN FRANCOIS , ROSSLET KLAUS , AZOULAY MICHEL , JACOOUESY JEAN-CLAUDE
IPC: C07H15/244 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K47/48 , A61P43/00
Abstract: Substrate-spacer-prodrug compounds (pro-prodrugs) suited for site specific delivery of drugs, a process of preparing them and their use are described.
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公开(公告)号：DE69425356D1
公开(公告)日：2000-08-31
申请号：DE69425356
申请日：1994-09-09
Applicant: HOECHST AG , HOECHST HOUDE S A LAB
Inventor： BOSSLET KLAUS , CZECH JOERG , HOFFMANN DIETER , TILLEQUIN FRANCOIS , FLORENT JEAN-CLAUDE , AZOULAY MICHEL , MONNERET CLAUDE , JACQUESY JEAN-CLAUDE , GESSON JEAN-PIERRE , KOCH MICHEL
IPC: C07H15/244 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K47/48 , A61P43/00
Abstract: Substrate-spacer-prodrug compounds (pro-prodrugs) suited for site specific delivery of drugs, a process of preparing them and their use are described.
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公开(公告)号：PT94406A
公开(公告)日：1991-03-20
申请号：PT9440690
申请日：1990-06-19
Applicant: HOECHST AG
Inventor： HOFFMANN DIETER , KRAEMER HANS PETER , FEHLHABER HANS-WOLFRAM , HEDTMANN UDO , SUKATSCH DIETER-ANDREAS
IPC: A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P35/00 , C07H15/252 , C12P19/56 , C12R1/00
Abstract: The present invention relates to anthracycline derivatives of the formula I in which R is the sugar residue Roa or the sugar combination Roa-Rod-Rod and R is the sugar residue Roa, where Roa represents rhodosamine of the formula II and Roa-Rod-Rod represents rhodosamine-rhodinose-rhodinose of the formula III and to the pharmacologically acceptable salts thereof and to a microbiological process for the preparation thereof. The compounds have cytostatic activity and can therefore be used as medicaments.
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