公开(公告)号：KR820000600B1

公开(公告)日：1982-04-16

申请号：KR770002744

申请日：1977-11-25

Applicant: HOECHST AG

Inventor： GEBERT V ,  CARTHEUSER C ,  THORWAST W ,  KOMAREK J

IPC: C07C83/04

Abstract: O-Alkylated hydroxylamine and acid added salts of formula I [X=DR1,SR1(R1=H, C1-C6 alkyl, C3-C6 cycloalkyl, haloalkyl) or NR2R3(R2,R3 = H, C1-C6 alkyl, C3-C7 cycloalkyl substituted with OH, C1-C4 alkoxy carbonyl were prepd. by two methods. Thus, MeC(oEt):NOH was added to Na in EtOH, then C1CH2CH(OH)CH2OH and the mixt. refluxed 30 min, and the product(64.5 % yield) MeC(oEt):NOCH2CH(OH)CH2OH deblocked by refluxing 15 min with 2N HC1 to give 93.4 % H2NOCH2CH(OH)CH2OHHCl. The title compds. are used as an antihypertensives.