公开(公告)号：ZA8800641B

公开(公告)日：1988-09-28

申请号：ZA8800641

申请日：1988-01-29

Applicant: HOECHST AG

Inventor： THORWART WERNER ,  WERNER THORWART ,  GEBERT ULRICH ,  ULRICH GEBERT ,  SCHLEYERBACH RUDOLF ,  RUDOLF SCHLEYERBACH ,  BARTLETT ROBERT R ,  ROBERT R BARTLETT

IPC: A61K31/54 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07D285/16 ,  C07D ,  A61K

CPC classification number: C07D285/16

公开(公告)号：OA08707A

公开(公告)日：1989-03-31

申请号：OA59264

申请日：1988-01-18

Applicant: HOECHST AG

Inventor： ULRICH GEBERT ,  ISMAHAN OKYAYUZ-BAKLOUTI ,  WERNER THORWART

IPC: A61K31/52 ,  A61K31/522 ,  A61P3/00 ,  A61P9/00 ,  C07D473/00 ,  A61P9/08 ,  A61P25/28 ,  C07D473/04 ,  C07D473/06 ,  C07D473/08 ,  C07D239/00 ,  C07D235/00 ,  A61K31/495

Abstract: PCT No. PCT/EP86/00401 Sec. 371 Date Mar. 16, 1987 Sec. 102(e) Date Mar. 16, 1987 PCT Filed Jul. 8, 1986 PCT Pub. No. WO87/00523 PCT Pub. Date Jan. 29, 1987.Tertiary hydroxyalkylxanthines having the general formula (I), characterized by the fact that at least one of the residues R1 and R3 represents a tertiary hydroxyalkyl group of formula (Ia) in which R4 represents an alkyl group having up to 3 carbon atoms and n a whole number from 2 to 5; the other residue which may remain R1 or R3 is a hydrogen atom or an aliphatic hydrocarbon residue R5 having up to 6 carbon atoms, in which the carbon chain may be separated by a maximum of two oxygen atoms or be substituted by an oxo group or two hydroxy groups at the most, and R2 represents an alkyl group with 1 to 4 carbon atoms. Also described is a process for manufacturing these compounds, which are suitable for the manufacture of medicines, in particular for use in the prevention and/or treatment of peripheral and/or cerebral irrigation disorders. (I) (Ia)

公开(公告)号：ZA88639B

公开(公告)日：1988-10-26

申请号：ZA88639

申请日：1988-01-29

Applicant: HOECHST AG

Inventor： THORWART WERNER ,  WERNER THORWART ,  GEBERT ULRICH ,  ULRICH GEBERT ,  SCHLEYERBACH RUDOLF ,  RUDOLF SCHLEYERBACH ,  BARTLETT ROBERT R ,  ROBERT R BARTLETT

IPC: A61K31/53 ,  A61P29/00 ,  C07D253/06 ,  C07D253/075 ,  C07D285/16 ,  C07D513/04 ,  C07D ,  A61K

Abstract: Novel substituted 3-phenyl-7H-thiazolo[3,2-b][1,2,4]-triazin-7-ones of the formula I are disclosed (I) in which R1, R2 and R3 have the meaning recited in the specification. The compounds are suitable for prevention and treatment of inflammatory disorders.

公开(公告)号：ZA92603B

公开(公告)日：1992-09-30

申请号：ZA92603

申请日：1992-01-29

Applicant: HOECHST AG

Inventor： THORWART WERNER ,  WERNER THORWART ,  RAISS RUTH ,  RUTH RAISS ,  GROETSCH HORST ,  HORST GROETSCH ,  SCHLEYERBACH RUDOLF ,  RUDOLF SCHLEYERBACH

IPC: A61K31/715 ,  A61P43/00 ,  C08B20060101 ,  C08B37/00 ,  C08B ,  A61K

Abstract: The invention concerns low-molecular sulphated poly- beta -2,6-fructofuranosanes containing monomer units of formula (I), as well as their use for the prophylaxis and treatment of degenerative articular ailments.

公开(公告)号：ZA9200603B

公开(公告)日：1992-09-30

申请号：ZA9200603

申请日：1992-01-29

Applicant: HOECHST AG

Inventor： THORWART WERNER ,  WERNER THORWART ,  RAISS RUTH ,  RUTH RAISS ,  GROETSCH HORST ,  HORST GROETSCH ,  SCHLEYERBACH RUDOLF ,  RUDOLF SCHLEYERBACH

IPC: A61K31/715 ,  A61P43/00 ,  C08B20060101 ,  C08B37/00 ,  C08B ,  A61K

CPC classification number: C08B37/0051

公开(公告)号：ZA9010067B

公开(公告)日：1991-09-25

申请号：ZA9010067

申请日：1990-12-14

Applicant: HOECHST AG

Inventor： THORWART WERNER ,  WERNER THORWART ,  SCHLEYERBACH RUDOLF ,  RUDOLF SCHLEYERBACH ,  BARTLETT ROBERT ,  ROBERT BARTLETT ,  WEITHMANN KLAUS ULRICH ,  KLAUS ULRICH WEITHMANN

IPC: A61K31/425 ,  A61K31/426 ,  A61P29/00 ,  A61P37/00 ,  C07D277/24 ,  C07D277/26 ,  C07D277/28 ,  C07D277/30 ,  C07D417/06 ,  C07D417/12 ,  C07D

Abstract: Novel substituted thiazoles of the formula I (I) in which R1 is a saturated or unsaturated, straight-chain or branched C1-C5-alkyl group, R2 is a hydrogen atom or an alkyl radical having 1 to 3 carbon atoms, A is an intermediate chain of the formula -(CH2)n-Y-CR3R4-; -CH=CR3-(CH2)m- or -CH=N-O-(CH2)n- where Y is a single bond, an oxygen or sulfur atom or a carbonyl group, R3 and R4 are identical or different and are a hydrogen atom or an alkyl radical having up to two carbon atoms, m is a number from 0 to 3 and n is a number from 1 to 4, and Z is a tetrazole or CN group, or a radical of the formula X is a hydroxyl group or a radical of the formula R5O- or R6R7N-, where R5 is a straight-chain or branched C1-C4-alkyl radical which is optionally substituted by hydroxyl, C1-C3-alkoxy or C1-C3-alkylamino, R6 and R7 are identical or different and are a hydrogen atom, a straight-chain or branched C1-C6-alkyl radicall or, for the case in which R6 is a hydrogen atom or a C1-C4-alkyl radical, R7 is a hydroxyl, a C1-C3-alkoxy or a tetrazol-5-yl group or X, together with the structural element -A-(C=O)-, is a radical of the formula II (II) where R8 is a hydrogen atom, a C1-C3-alkyl radical or a C1-C3-alkoxy radical, and physiologically tolerable salts of such compounds of the formula I in which X is a hydroxyl or hydroxyamino group, are prepared by various processes. They are preferably suitable for the treatment and prophylaxis of inflammatory diseases - in particular inflammatory rheumatic diseases.

公开(公告)号：OA8707A

公开(公告)日：1989-03-31

申请号：OA59264

申请日：1988-01-18

Applicant: HOECHST AG

Inventor： ULRICH GEBERT ,  ISMAHAN OKYAYUZ-BAKLOUTI ,  WERNER THORWART

IPC: C07D473/00 ,  A61K31/52 ,  A61K31/522 ,  A61P3/00 ,  A61P9/00 ,  A61P9/08 ,  A61P25/28 ,  C07D473/04 ,  C07D473/06 ,  C07D473/08 ,  A61K31/495 ,  C07D235/00 ,  C07D239/00

CPC classification number: C07D473/06 ,  C07D473/08

公开(公告)号：ZA8800639B

公开(公告)日：1988-10-26

申请号：ZA8800639

申请日：1988-01-29

Applicant: HOECHST AG

Inventor： THORWART WERNER ,  WERNER THORWART ,  GEBERT ULRICH ,  ULRICH GEBERT ,  SCHLEYERBACH RUDOLF ,  RUDOLF SCHLEYERBACH ,  BARTLETT ROBERT R ,  ROBERT R BARTLETT

IPC: A61K31/53 ,  A61P29/00 ,  C07D253/06 ,  C07D253/075 ,  C07D285/16 ,  C07D513/04 ,  C07D ,  A61K

CPC classification number: C07D253/075 ,  C07D285/16 ,  C07D513/04

公开(公告)号：ZA88641B

公开(公告)日：1988-09-28

申请号：ZA88641

申请日：1988-01-29

Applicant: HOECHST AG

Inventor： THORWART WERNER ,  WERNER THORWART ,  GEBERT ULRICH ,  ULRICH GEBERT ,  SCHLEYERBACH RUDOLF ,  RUDOLF SCHLEYERBACH ,  BARTLETT ROBERT R ,  ROBERT R BARTLETT

IPC: A61K31/54 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07D285/16 ,  C07D417/04 ,  C07D ,  A61K

Abstract: Novel 5-(3-alkyl-5-tert.butyl-4-hydroxyphenyl)-2-amino-6H-1,3,4-thiadiazines of the general formula I (I) in which R1=C1-C4-alkyl, R2=H or C1-C3-alkyl R3 and R4=independently of one another, optionally substituted and optionally O- or S-interrupted alkyl, alkenyl or alkynyl groups, it being possible for one of the two radicals to also be H, or R3+R4 together with the nitrogen atom to which they are bound, may denote an optionally substituted 4- to 7-membered ring which optionally contains a further heteroatom (O, S or N), and the physiologically acceptable acid-addition salts thereof. The compounds are primarily suitable for prevention and treatment of inflammatory-in particular inflammatory rheumatic-disorders and/or pain.