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    NOVEL 2-SUBSTITUTED 4-(3-ALKYL-5-TERT.-BUTYL-4-HYDROXYPHENYL)THIAZOLES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICALS CONTAINING THEM AND THEIR USE
    8.
    发明专利
    NOVEL 2-SUBSTITUTED 4-(3-ALKYL-5-TERT.-BUTYL-4-HYDROXYPHENYL)THIAZOLES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICALS CONTAINING THEM AND THEIR USE 未知

    公开(公告)号：AU630261B2

    公开(公告)日：1992-10-22

    申请号：AU6802490

    申请日：1990-12-14

    Applicant: HOECHST AG

    Inventor： THORWART WERNER ,  SCHLEYERBACH RUDOLF ,  BARTLETT ROBERT ,  WEITHMANN KLAUS-ULRICH

    IPC: A61K31/425 ,  A61K31/426 ,  A61P29/00 ,  A61P37/00 ,  C07D277/24 ,  C07D277/26 ,  C07D277/28 ,  C07D277/30 ,  C07D417/06 ,  C07D417/12

    Abstract: Novel substituted thiazoles of the formula I (I) in which R1 is a saturated or unsaturated, straight-chain or branched C1-C5-alkyl group, R2 is a hydrogen atom or an alkyl radical having 1 to 3 carbon atoms, A is an intermediate chain of the formula -(CH2)n-Y-CR3R4-; -CH=CR3-(CH2)m- or -CH=N-O-(CH2)n- where Y is a single bond, an oxygen or sulfur atom or a carbonyl group, R3 and R4 are identical or different and are a hydrogen atom or an alkyl radical having up to two carbon atoms, m is a number from 0 to 3 and n is a number from 1 to 4, and Z is a tetrazole or CN group, or a radical of the formula X is a hydroxyl group or a radical of the formula R5O- or R6R7N-, where R5 is a straight-chain or branched C1-C4-alkyl radical which is optionally substituted by hydroxyl, C1-C3-alkoxy or C1-C3-alkylamino, R6 and R7 are identical or different and are a hydrogen atom, a straight-chain or branched C1-C6-alkyl radicall or, for the case in which R6 is a hydrogen atom or a C1-C4-alkyl radical, R7 is a hydroxyl, a C1-C3-alkoxy or a tetrazol-5-yl group or X, together with the structural element -A-(C=O)-, is a radical of the formula II (II) where R8 is a hydrogen atom, a C1-C3-alkyl radical or a C1-C3-alkoxy radical, and physiologically tolerable salts of such compounds of the formula I in which X is a hydroxyl or hydroxyamino group, are prepared by various processes. They are preferably suitable for the treatment and prophylaxis of inflammatory diseases - in particular inflammatory rheumatic diseases.

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