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    PRODUCTION OF N-LAUROYL-L-GLUTAMIC ACID-DI-N-BUTYLAMIDE
    1.
    发明专利
    PRODUCTION OF N-LAUROYL-L-GLUTAMIC ACID-DI-N-BUTYLAMIDE 失效

    公开(公告)号：JPH101463A

    公开(公告)日：1998-01-06

    申请号：JP6128097

    申请日：1997-03-14

    Applicant: HOECHST AG

    Inventor： ENGELHARDT FRITZ DR ,  MUELLER MANFRED ,  WESLING MICHAEL DR

    IPC: C07C231/02 ,  C07C231/24 ,  C07C237/22

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject high-purity compound in high yield without causing waste water, by reacting N-lauroyl-L-glutamic acid dimethyl ester with n-butylamine in the presence of a specific auxiliary solvent. SOLUTION: N-Lauroyl-L-glutamic acid dimethyl ester (hereinafter abbreviated as the ester) is reacted with n-butylamine in the presence of a hydrocarbon or a hydrocarbon mixture as an auxiliary solvent. n-Nonane, n-decane and a high-boiling multi-alkylated cyclohexane derivative having >=100 deg.C boiling point are preferable as the hydrocarbon. The ratio of the auxiliary solvent to the ester used is preferably 50-150wt.%. The amount of the n-butylamine used is preferably 3-6mol based on 1mol of the ester. Preferably, after the reaction, excessive n-butylamine is removed by distillation and a polar solvent such as acetone is added to the reaction mixture to precipitate the objective compound.

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