中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

79 records (took 0.02 seconds)

    PROCESS FOR PREPARING 1-ETHYL-2-(PHENYL-OXYMETHYL)-5-NITRO-IMIDAZOLES
    1.
    发明授权
    PROCESS FOR PREPARING 1-ETHYL-2-(PHENYL-OXYMETHYL)-5-NITRO-IMIDAZOLES 失效

    公开(公告)号：KR810000071B1

    公开(公告)日：1981-02-12

    申请号：KR770000946

    申请日：1977-04-20

    Applicant: HOECHST AG

    Inventor： RAETHER W ,  WINKELMANN E

    IPC: A61K31/415 ,  C07D233/94

    Abstract: Title compds. (I; A = O, S; R1 = methyl or ethyl; R2 = H, methyl or halogen), useful as protozoacides, were prepd. by the reaction of II(X= halogen, acyloxy, arylsulfonyloxy) and III(Y= H, alkali metal or ammonium). Thus, 14.0 g 4-methyl-mercaptophenol and 19.0 g 1-ethyl-2-chloro-methyl-5-nitroimidazole were stirred at 25≦̸C in DMF soln. in the presence of K2CO3 to give 17.0 g 1-ethyl-2-(4-methyl-thiophenyloxy-methyl)-5-nitroimidazole.

    PROCESS FOR 1-METHYL-2-(PHENYL-OXYMETHYL)-5-NITRO-IMIDAZOLES
    2.
    发明授权
    PROCESS FOR 1-METHYL-2-(PHENYL-OXYMETHYL)-5-NITRO-IMIDAZOLES 失效

    公开(公告)号：KR800001476B1

    公开(公告)日：1980-12-17

    申请号：KR760000122

    申请日：1976-01-16

    Applicant: HOECHST AG

    Inventor： WINKELMANN E ,  RAETHER W

    IPC: A61K31/40 ,  C07D233/95

    Abstract: Title compds. (I, A = S or -SO-; R = C1-3 alkyl), useful as protozoaides, were prepd. by reacting nitro-imidazole(II; X = halogen, acyloxy, acryloxysulfonyloxy) and phenol(III; Y = H, alkaline metal ion or ammonium) or by alkylating nitroimidazole(IV) or by oxidizing I(A = S) to I(A = -SO-). Thus, 4-methylmercapto-phenol of 1-1:1-methyl-2-(4-methylthiophenyl-oxyethyl)-5-nitro-imidazole dissolved in DMF, powdered K2CO3 and 1-methyl-2-chloromethyl-5-nitro-imidazole were mixed under 35≦̸C to give 1-methyl-2-(4-methylthiophenyl-oxymethyl)-nitro-imdazole(m.p. 116≦̸C).

    PROCESS FOR 1-ALKYL-2-(PHENOXYL METHYL)-S-NITRO-IMIDAZOLE
    3.
    发明授权
    PROCESS FOR 1-ALKYL-2-(PHENOXYL METHYL)-S-NITRO-IMIDAZOLE 失效

    公开(公告)号：KR800001147B1

    公开(公告)日：1980-10-14

    申请号：KR770000423

    申请日：1977-02-24

    Applicant: HOECHST AG

    Inventor： WINKELMANN E

    IPC: C07D207/333

    Abstract: Title imidazoles (I, R1 = methyl, R2 = methylsulfonyl, ethylsulfonyl, R3 = H, methyl, halogen) are prepd. by oxidation of 1-methyl-2-(penoxymethyl)-5-nitroimidazoles (II, A = sulfur atom, sulfoxide group(-s) at 40o-60oC in solvent. Thus, 27.9g l-methyl-2-(4-methylthio-phenoxy-methyl)-5-nitroimidazole) was dissolved in 250ml acetic anhydride and heated with 30% hydroperoxide 24.3g at 60oC for 1hr. to give 29g 1-methyl-2-(4-methylsulfonyl-phenoxymethyl)-5-nitroimidazole.

    PROCESS PREPARING FOR 1-ALKYL-2-(PHENOXYMETHYL)-5-NITRO-IMIDAZOLES
    5.
    发明授权
    PROCESS PREPARING FOR 1-ALKYL-2-(PHENOXYMETHYL)-5-NITRO-IMIDAZOLES 失效

    公开(公告)号：KR800001248B1

    公开(公告)日：1980-10-25

    申请号：KR750001508

    申请日：1975-07-09

    Applicant: HOECHST AG

    Inventor： RAETHER W ,  WINKELMANN E

    IPC: C07D233/66

    Abstract: 1-Alky1-2-(phenoxymethy1)-5-nitroimidazoles (I; R1 = methy1, ethy1; R2 = trifluoromethy1, trichloromethy1, nitro, cyano, methylsulfony1, ethylsulfony1; R3 = H, F, Cl, Br, I, trifluoromethy1, trichloromethy1, cyano, nitro; X = halogen, acyloxy, arylsulfonyloxy), useful as protozoacides(no data), were prepd. by reaction of alky1-2-halogenomethy1-5-nitroimidazole(II) with phenol derivs.(III).

Patent Agency Ranking