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    Reagent stripe for test strip
    1.
    发明专利
    Reagent stripe for test strip 有权
    用于测试条的试纸条

    公开(公告)号：JP2011203268A

    公开(公告)日：2011-10-13

    申请号：JP2011127587

    申请日：2011-06-07

    Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

    Inventor： BURKE DAVID W ,  MARQUANT MICHAEL ,  ZAPF UDO ,  FRITZ MICHAEL ,  MOSOIU DAN ,  WILSEY CHRISTOPHER D

    IPC: G01N27/327 ,  G01N27/26 ,  G01N27/28 ,  G01N27/416 ,  G01N31/22 ,  G01N33/00 ,  G01N33/487 ,  G01N33/558

    CPC classification number: G01N33/558 ,  G01N27/3271 ,  Y10T156/1059 ,  Y10T156/1084

    Abstract: PROBLEM TO BE SOLVED: To provide a test strip or a biosensor for testing the concentration of an analyte in a body fluid.SOLUTION: The test strip includes a base substrate (12), a spacing layer (14) and a covering layer (16) comprising a body cover (18) and a chamber cover (20). The spacing layer includes a void portion (22) to provide a sample-receiving chamber. The base substrate carries an electrode system (26) including electrodes (28) and terminating in contact pads (32). The electrodes are defined as those portions of electrodes traces that are positioned within the sample-receiving chamber. A suitable reagent system (33) overlies the electrodes within the sample-receiving chamber. The body cover and the chamber cover overlying the spacing layer define a slot (34) therebetween, the slot defining a vent opening communicating with the sample-receiving chamber to allow air to escape the chamber as a sample fluid enters the chamber from the edge opening or fluid receiving opening.

    Abstract translation: 要解决的问题：提供一种用于测试体液中分析物浓度的测试条或生物传感器。解决方案：测试条包括基底（12），间隔层（14）和覆盖层（16） ）包括主体盖（18）和室盖（20）。 间隔层包括空穴部分（22）以提供样品接收室。 基底衬底承载包括电极（28）并终止于接触焊盘（32）的电极系统（26）。 电极被定义为位于样品接收室内的电极迹线部分。 合适的试剂系统（33）覆盖在样品接收室内的电极上。 覆盖间隔层的主体盖和腔盖在其间限定一个狭槽（34），该狭槽限定了一个与样品容纳室连通的通气口，当样品流体从边缘开口进入腔室时，允许空气逸出室 或流体接收开口。

    METHODS AND DEVICES FOR CONTROLLING THE IMPACT OF SHORT CIRCUIT FAULTS ON CO-PLANAR ELECTROCHEMICAL SENSORS
    4.
    发明申请
    METHODS AND DEVICES FOR CONTROLLING THE IMPACT OF SHORT CIRCUIT FAULTS ON CO-PLANAR ELECTROCHEMICAL SENSORS 审中-公开
    用于控制短周期电路故障对CO-PLANAR电化学传感器的影响的方法和装置

    公开(公告)号：WO2006133878A3

    公开(公告)日：2007-05-31

    申请号：PCT/EP2006005611

    申请日：2006-06-12

    Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  GROLL HENNING ,  BURKE DAVID W

    Inventor： GROLL HENNING ,  BURKE DAVID W

    IPC: G01N33/487 ,  C12Q1/00

    CPC classification number: G01N27/3272

    Abstract: Methods and devices are provided for controlling the impact of undesirable short circuits between non-adjacent but critically matched pairs of electrodes in a co-planar electrochemical sensor. In one embodiment, the size and/or shape of at least one electrode is configured to induce a short circuit between electrode pairs for which connectivity is pre-set to be measured by a meter in order to indicate a short circuit between a different pair for which such connectivity is not pre-set to be measured, hi another embodiment, the surface area of one or more electrodes, other than the working electrode, which are designed to be exposed to a sample fluid is significantly limited in relation to the surface area of the working electrode that is exposed to the sample fluid.

    Abstract translation: 提供的方法和装置用于控制共面电化学传感器中不相邻但是非常匹配的电极对之间的不期望的短路的冲击。 在一个实施例中，至少一个电极的尺寸和/或形状被配置为引起电极对之间的短路，对于这些短路，连通性被预先设定为由电表测量，以便指示不同对之间的短路 其中这种连接不被预先设定为被测量。在另一实施例中，被设计为暴露于样品流体的除了工作电极之外的一个或多个电极的表面积相对于表面积 的暴露于样品流体的工作电极。

    SYSTEM AND METHOD FOR DETERMINING AN ABUSED SENSOR DURING ANALYTE MEASUREMENT IN A BIOLOGICAL FLUID
    5.
    发明申请
    SYSTEM AND METHOD FOR DETERMINING AN ABUSED SENSOR DURING ANALYTE MEASUREMENT IN A BIOLOGICAL FLUID 审中-公开
    用于在生物流体中分析测量期间确定传感器的系统和方法

    公开(公告)号：WO2005001462A8

    公开(公告)日：2005-03-17

    申请号：PCT/US2004019640

    申请日：2004-06-18

    Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  BURKE DAVID W ,  KUHN LANCE S ,  MAXWELL JAMES L

    Inventor： BURKE DAVID W ,  KUHN LANCE S ,  MAXWELL JAMES L

    IPC: G01N27/02 ,  G01N33/487 ,  G01N27/416 ,  G01N27/327

    CPC classification number: G01N27/3274 ,  G01N27/02 ,  G01N27/121 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/142222 ,  Y10T436/143333 ,  Y10T436/144444

    Abstract: A method for detecting an abused sensor for determining concentration of a medically significant component of a biological fluid placed upon the sensor comprising the steps of: a) placing the biological fluid sample upon the sensor; b) applying a first DC signal to the biological fluid; c) measuring a current response to the first DC signal; d) repeating step (c) at least once; e) calculating a normalized Cottrell Failsafe Ratio using the current response data; f) applying a second signal having an AC component to the biological fluid; g) measuring an AC response to the second signal; and h) combining the normalized Cottrell Failsafe Ratio and the AC response to produce an indication of whether the sensor has been abused.

    Abstract translation: 一种用于检测用于确定放置在传感器上的生物流体的医学重要组分的浓度的滥用传感器的方法，包括以下步骤：a）将生物流体样品放置在传感器上; b）向所述生物流体施加第一DC信号; c）测量对第一DC信号的电流响应; d）重复步骤（c）至少一次; e）使用当前响应数据计算归一化Cottrell失效保险比; f）向所述生物流体施加具有AC分量的第二信号; g）测量对所述第二信号的AC响应; 并且h）将归一化的Cottrell故障安全比和AC响应组合以产生传感器是否被滥用的指示。

    SYSTEM AND METHOD FOR DETERMINING AN ABUSED SENSOR DURING ANALYTE MEASUREMENT IN A BIOLOGICAL FLUID
    7.
    发明专利
    SYSTEM AND METHOD FOR DETERMINING AN ABUSED SENSOR DURING ANALYTE MEASUREMENT IN A BIOLOGICAL FLUID 未知

    公开(公告)号：CA2530300C

    公开(公告)日：2018-01-09

    申请号：CA2530300

    申请日：2004-06-18

    Applicant: HOFFMANN LA ROCHE

    Inventor： BURKE DAVID W ,  KUHN LANCE S ,  MAXWELL JAMES L

    IPC: G01N27/416 ,  G01N27/02 ,  G01N27/327 ,  G01N33/487

    Abstract: A method for detecting an abused sensor for determining concentration of a medically significant component of a biological fluid placed upon the sensor comprising the steps of: a) placing the biological fluid sample upon the sensor; b) applying a first DC signal to the biological fluid; c) measuring a current response to the first DC signal; d) repeating step (c) at least once; e) calculating a normalized Cottrell Failsafe Ratio using the current response data; f) applying a second signal having an AC component to the biological fluid; g) measuring an AC response to the second signal; and h) combining the normalized Cottrell Failsafe Ratio and the AC response to produce an indication of whether the sensor has been abused.

    REAGENT STRIPE FOR TEST STRIP
    9.
    发明专利
    REAGENT STRIPE FOR TEST STRIP 未知

    公开(公告)号：CA2530297A1

    公开(公告)日：2004-12-29

    申请号：CA2530297

    申请日：2004-06-18

    Applicant: HOFFMANN LA ROCHE

    Inventor： BURKE DAVID W ,  MARQUANT MICHAEL ,  WILSEY CHRISTOPHER D ,  FRITZ MICHAEL ,  MOSOIU DAN ,  ZAPF UDO

    IPC: G01N27/30 ,  C12Q1/00 ,  G01N27/26 ,  G01N31/22 ,  G01N33/00 ,  G01N33/487 ,  G01N33/558

    Abstract: A test strip (10) having a small sample-receiving chamber on the order of le ss than 1 microliter includes a reagent layer (33) that extends across the widt h of the test strip and also extends to the sample-receiving end (36), such th at the edges of the reagent layer are aligned with the side and dose receiving edges of the test strip. The hydrophilic reagent extending to the dosing edg e of the strip promotes wicking of the sample into the test strip. The end and side edges of the reagent layer are preferably formed as part of a cutting process that forms individual test strips from a larger web, which results i n a smooth and thin reagent layer with a uniform thickness, substantially covering the entire floor of the sample-receiving chamber. The inventive mas s production process helps improve the reproducibility of the quantity, location, thickness and other properties of the reagent layer, which in turn improves the accuracy of the test result.

    SYSTEM AND METHOD FOR ANALYTE MEASUREMENT USING DOSE SUFFICIENCY ELECTRODES
    10.
    发明专利
    SYSTEM AND METHOD FOR ANALYTE MEASUREMENT USING DOSE SUFFICIENCY ELECTRODES 未知

    公开(公告)号：CA2814802C

    公开(公告)日：2016-05-24

    申请号：CA2814802

    申请日：2004-06-18

    Applicant: HOFFMANN LA ROCHE

    Inventor： BURKE DAVID W ,  SURRIDGE NIGEL A ,  GROLL HENNING

    IPC: G01N27/403 ,  G01N27/02 ,  G01N27/416 ,  G01N33/487 ,  G01N33/66

    Abstract: Described is a test strip including a capillary fill chamber extending a length along the test strip from an intake opening to a terminus, a first pair of electrodes in operative communication with the chamber, and a second pair of electrodes in operative communication with the chamber. Also described is a method for indicating acceptable fill time of biological fluid in the test strip. The method may be employed, for example, as part of determination of concentration of a substance such as in medical diagnosis, for example measurement of glucose in a blood, which is important in treatment of diabetes; the method of the invention provides a more accurate measurement than in the prior methods, even in the presence of confounding variables.

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