公开(公告)号：JP2010243514A

公开(公告)日：2010-10-28

申请号：JP2010177438

申请日：2010-08-06

Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

Inventor： BHULLAR RAGHBIR SINGH ,  SURRIDGE NIGEL A ,  FUNKE TOM ,  RIGGLES RANDALL K ,  WALLING PAUL DOUGLAS

IPC: G01N27/327 ,  G01N27/26 ,  G01N27/416 ,  G01N31/22 ,  G01N33/00 ,  G01N33/487 ,  G01N33/558

CPC classification number: G01N33/558 ,  G01N27/3271 ,  Y10T156/1059 ,  Y10T156/1084

Abstract: PROBLEM TO BE SOLVED: To provide a test strip with a sample-receiving chamber having a novel flared portion that terminates, in a sample-receiving opening. SOLUTION: The method for producing a test strip includes (a) a process which prepares a base substrate, a pitch layer and a cover layer; (b) a process which has an elongated section and a spherical section to form a space extending into the pitch layer; (c) a process which laminates a space layer on the base substrate used as the base and laminates the cover layer on the pitch layer to form a test strip precursor section; and (d) a cutting of a part of the precursor section, to produce the test strip, where a process is included, such that the cutting traverses a spherical section of the space formed at the process (b) to form a sample receiving edge of the test strip and the space demarcates the sample-receiving chamber which has an entrance section terminating within the sample receiving opening at the sample-receiving terminal edge of the test strip. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：为了提供具有样品接收室的测试条，其具有在样品接收开口中终止的新颖的扩口部分。 测试条的制造方法包括（a）准备基底基板，间距层和覆盖层的工序。 （b）具有细长部分和球形部分以形成延伸到沥青层中的空间的方法; （c）将用作基底的基底层叠空间层并层叠沥青层上的覆盖层以形成测试条前体部分的方法; 和（d）切割前体部分的一部分，以产生包含工艺的测试条，使得切割穿过在工艺（b）形成的空间的球形部分，以形成样品接收边缘 并且所述空间划分所述样品接收室，所述样品接收室具有终止于所述测试条的所述样品接收端边缘处的所述样品接收开口内的入口部分。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：PL1639353T3

公开(公告)日：2018-11-30

申请号：PL04755692

申请日：2004-06-18

Applicant: HOFFMANN LA ROCHE

Inventor： BHULLAR RAGHBIR SINGH ,  SURRIDGE NIGEL A ,  FUNKE TOM ,  RIGGLES RANDALL K ,  WALLING PAUL DOUGLAS

IPC: G01N27/30 ,  C12Q1/00 ,  G01N27/26 ,  G01N31/22 ,  G01N33/00 ,  G01N33/487 ,  G01N33/558

公开(公告)号：CA2814802C

公开(公告)日：2016-05-24

申请号：CA2814802

申请日：2004-06-18

Applicant: HOFFMANN LA ROCHE

Inventor： BURKE DAVID W ,  SURRIDGE NIGEL A ,  GROLL HENNING

IPC: G01N27/403 ,  G01N27/02 ,  G01N27/416 ,  G01N33/487 ,  G01N33/66

Abstract: Described is a test strip including a capillary fill chamber extending a length along the test strip from an intake opening to a terminus, a first pair of electrodes in operative communication with the chamber, and a second pair of electrodes in operative communication with the chamber. Also described is a method for indicating acceptable fill time of biological fluid in the test strip. The method may be employed, for example, as part of determination of concentration of a substance such as in medical diagnosis, for example measurement of glucose in a blood, which is important in treatment of diabetes; the method of the invention provides a more accurate measurement than in the prior methods, even in the presence of confounding variables.

公开(公告)号：CA2714309C

公开(公告)日：2013-08-06

申请号：CA2714309

申请日：2004-06-18

Applicant: HOFFMANN LA ROCHE

Inventor： BURKE DAVID W ,  SURRIDGE NIGEL A ,  GROLL HENNING

IPC: G01N27/416 ,  G01N27/02 ,  G01N27/403 ,  G01N27/404 ,  G01N33/487

Abstract: A method of performing a measurement on a biological fluid or of indicating acceptable fill time of biological fluid in a test strip; the method may be employed, for example, as part of determination of concentration of a substance such as in medical diagnosis, for example measurement of glucose in a blood, which is important in treatment of diabetes; the method of the invention provides a more accurate measurement than in the prior methods, even in the presence of confounding variables; the method comprises providing a biological fluid test strip including a capillary fill chamber extending a length along the test strip from an intake opening to a terminus, a first pair of electrodes in operative communication with the chamber, and a second pair of electrodes in operative communication with the chamber; dosing the test strip with a biological fluid effective to cause the biological fluid to flow from the intake opening toward the terminus; for the performing of the measurement, a first test signal is applied to one of the first pair of electrodes; a first response to the first test signal is measured at the other of the first pair of electrodes; the first pair of electrodes is maintained in an inoperative state upon measuring the first response; a second test signal is applied to one of the second pair of electrodes while the first pair of electrodes is in said inoperative state; a second response to the second test signal is measured at the other of the second pair of electrodes; and a measurement is performed upon the biological fluid after measuring the second response.

公开(公告)号：CA2530052C

公开(公告)日：2010-11-30

申请号：CA2530052

申请日：2004-06-18

Applicant: HOFFMANN LA ROCHE

Inventor： BURKE DAVID W ,  SURRIDGE NIGEL A ,  GROLL HENNING

IPC: G01N27/30 ,  G01N27/02 ,  G01N27/327 ,  G01N33/487

Abstract: A method of determining dose sufficiency related parameters in a test strip for performing a measurement on a biological fluid comprising: a capillary fill chamber extending a length along the test strip from an intake opening to a terminus, a reagent disposed in the capillary fill chamber between the opening and the terminus, the reagent defining a measurement zone, and at least two dose sufficiency electrodes defining a gap there between and in operative with the capillary fill, chamber, the electrodes located between the measurement zone and the terminus; applying the biological fluid to the opening, whereby the fluid flows from the opening towards the terminus; applying an AC test signal to a first one of the electrodes; determining the presence or absence of a response above a predetermined threshold at the second one of the electrodes, the response indicating that the fluid has occupied substantially all of the measurement zone.

公开(公告)号：CA2529430A1

公开(公告)日：2005-07-21

申请号：CA2529430

申请日：2004-06-18

Applicant: HOFFMANN LA ROCHE

Inventor： WALLING PAUL DOUGLAS ,  HILL BRIAN S ,  DIEBOLD ERIC R ,  BHULLAR RAGHBIR SINGH ,  SURRIDGE NIGEL A

IPC: G01N27/30 ,  B23K26/36 ,  C12Q1/00 ,  G01N27/403 ,  G01N33/487 ,  G01N33/49 ,  G01N33/543 ,  H05K1/00 ,  H05K3/02

Abstract: An electrochemical biosensor (210) with electrode elements (274, 276) that possess smooth, high-quality edges (281, 283, 285, 287) with an edge definition better than 6~m. These smooth edges define gaps between electrode s, electrode traces and contact pads. Due to the remarkable edge smoothness achieved, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities th at can be packed into a single biosensor. Further, the present application provides a biosensor production method in which entire electrode patterns fo r the inventive biosensors can be formed all at one, in nanoseconds - without regard to the complexity of the electrode patterns or the amount of conducti ve material that must be ablated to form them.

公开(公告)号：CA2714309A1

公开(公告)日：2005-01-27

申请号：CA2714309

申请日：2004-06-18

Applicant: HOFFMANN LA ROCHE

Inventor： BURKE DAVID W ,  SURRIDGE NIGEL A ,  GROLL HENNING

IPC: G01N27/416 ,  G01N27/02 ,  G01N27/403 ,  G01N27/404 ,  G01N33/487

Abstract: A method of performing a measurement on a biological fluid or of indicating acceptable fill time of biological fluid in a test strip comprising providing a biological fluid test strip including a capillary fill chamber extending a length along the test strip from an intake opening to a terminus, a first pair of electrodes in operative communication with the chamber, and a second pair of electrodes in operative communication with the chamber; dosing the test strip with a biological fluid effective to cause the biological fluid to flow from the intake opening toward the terminus; for the performing of the measurement, a first test signal is applied to one of the first pair of electrodes; a first response to the first test signal is measured at the other of the first pair of electrodes; the first pair of electrodes is maintained in an inoperative state upon measuring the first response; a second test signal is applied to one of the second pair of electrodes while the first pair of electrodes is in said inoperative state; a second response to the second test signal is measured at the other of the second pair of electrodes; and a measurement is performed upon the biological fluid after measuring the second response; for indicating acceptable fill time of the biological fluid in the test strip; biological fluid is flowed from the opening toward the terminus; a first determination is made when the biological fluid contacts the first electrodes; a second determination is made when the biological fluid contacts the second electrodes; a fill time value is determined based upon the first determining and the second determining; and an error condition is indicated if the fill time value is greater than a predetermined value, and a measurement is performed upon the biological fluid if the fill time value is less than a predetermined value; a suitable test strip of the invention for performing a measurement on a biological fluid comprises a capillary fill chamber extending a length along the test strip from an opening to a terminus; at least two measurement electrodes in operative communication with the chamber, and at least two dose sufficiency electrodes in operative communication with the chamber; wherein the dose sufficiency electrodes have first edges substantially parallel to the length of the capillary chamber and second edges substantially perpendicular to the length of the capillary fill chamber, the first edges being of greater length than the second edges.

公开(公告)号：ES2681398T3

公开(公告)日：2018-09-12

申请号：ES04755692

申请日：2004-06-18

Applicant: HOFFMANN LA ROCHE

Inventor： BHULLAR RAGHBIR SINGH ,  SURRIDGE NIGEL A ,  FUNKE TOM ,  RIGGLES RANDALL K ,  WALLING PAUL DOUGLAS

IPC: G01N27/30 ,  C12Q1/00 ,  G01N27/26 ,  G01N31/22 ,  G01N33/00 ,  G01N33/487 ,  G01N33/558

Abstract: Una tira reactiva (10, 300, 350, 400, 500, 512, 524) para analizar un líquido, que comprende: un cuerpo de tira reactiva que define una cámara de recepción de muestra (24, 354, 404, 504, 516) que tiene una porción ensanchada (328, 352, 402, 518, 530, 532) que termina en un orificio de recepción de líquido y una porción alargada (332, 532) que se extiende hacia el interior desde la porción ensanchada (328, 352, 402, 518, 530, 532), en el que la porción alargada (332, 532) se define por un par de paredes laterales opuestas sustancialmente paralelas y una pared de extremo que conecta las paredes laterales, y en el que la porción ensanchada (328, 352, 402, 518, 530, 532) se define por un par de paredes que se estrechan en una dirección hacia la porción alargada (332, 532); definiendo el cuerpo de tira reactiva una ventilación en comunicación con la cámara de recepción de muestra (24, 354, 404, 504, 516), por lo que el aire puede escapar de la ventilación a medida que el líquido es aspirado en la cámara de recepción de muestra (24, 354, 404, 504, 516); comprendiendo el cuerpo de tira reactiva además: un sustrato de base (12), una capa de cubierta (16) que cubre el sustrato de base (12) y una capa espaciadora (14) intercalada entre el sustrato de base (12) y la capa de cubierta (16), definiendo la capa espaciadora (14) un vacío que define el perímetro de la cámara de recepción de muestra (24, 354, 404, 504, 516) entre el sustrato de base (12) y la capa de cubierta (16); y comprendiendo la tira reactiva (10, 300, 350, 400, 500, 512, 524) además un área de prueba dispuesta en la cámara de recepción de muestra (24, 354, 404, 504, 516) para analizar el líquido; en la que el orificio de recepción de líquido (35) está dispuesto en un extremo de recepción de líquido cónico de la tira reactiva (10, 300, 350, 400, 500, 512, 524).

公开(公告)号：CA2900885A1

公开(公告)日：2014-09-18

申请号：CA2900885

申请日：2014-03-13

Applicant: HOFFMANN LA ROCHE

Inventor： BEATY TERRY A ,  CARPENTER SCOTT E ,  PAN ZHENG ZHENG ,  SURRIDGE NIGEL A

IPC: G01N27/327

Abstract: Methods are disclosed for measuring an analyte concentration in a fluidic sample. Such methods further allow one to correct and/or compensate for confounding variables such as hematocrit (Hct), temperature or both before providing an analyte concentration. The measurement methods utilize information obtained from test sequences having at least one AC block and at least one pulsed DC block, where pulsed DC block includes at least one recovery potential, and where a closed circuit condition of the electrode system is maintained during the DC block. Also disclosed are devices, apparatuses and systems incorporating the various measurement methods.

公开(公告)号：CA2530052A1

公开(公告)日：2005-01-27

申请号：CA2530052

申请日：2004-06-18

Applicant: HOFFMANN LA ROCHE

Inventor： BURKE DAVID W ,  SURRIDGE NIGEL A ,  GROLL HENNING

IPC: G01N27/30 ,  G01N27/02 ,  G01N27/327 ,  G01N33/487

Abstract: A method of determining dose sufficiency related parameters in a test strip for performing a measurement on a biological fluid comprising: a capillary fill chamber extending a length along the test strip from an intake opening to a terminus, a reagent disposed in the capillary fill chamber between the opening and the terminus, the reagent defining a measurement zone, and at least two dose sufficiency electrodes defining a gap there between and in operative with the capillary fill, chamber, the electrodes located between t he measurement zone and the terminus; applying the biological fluid to the opening, whereby the fluid flows from the opening towards the terminus; applying an AC test signal to a first one of the electrodes; determining the presence or absence of a response above a predetermined threshold at the second one of the electrodes, the response indicating that the fluid has occupied substantially all of the measurement zone.