公开(公告)号：RS53183B

公开(公告)日：2014-06-30

申请号：YUP20050892

申请日：2004-06-01

Applicant: HOFFMANN LA ROCHE

Inventor： BUETTELMANN BERND ,  CECCARELLI SIMONA MARIA ,  JAESCHKE GEORG ,  PORTER RICHARD HUGH PHILIP ,  VIEIRA ERIC ,  KOLCZEWSKI SABINE

IPC: C07D401/06 ,  A61K31/4439 ,  A61K31/444 ,  A61P25/28 ,  C07D401/14

Abstract: The present invention relates to imidazole derivatives of formula I wherein R1, R2, R3 and R4 are described hereinabove. These compounds can be used in the treatment or prevention of mGluR5 receptor mediated disorders. These compounds are useful, inter alia, in the treatment or prevention of acute and/or chronic neurological disorders such as psychosis, epilepsy, schizophrenia, Alzheimer' disease, cognititve disorders and memory deficits, as well as chronic and acute pain.

公开(公告)号：CA2568725C

公开(公告)日：2012-11-27

申请号：CA2568725

申请日：2005-05-23

Applicant: HOFFMANN LA ROCHE

Inventor： BUETTELMANN BERND ,  CECCARELLI SIMONA MARIA ,  JAESCHKE GEORG ,  KOLCZEWSKI SABINE ,  PORTER RICHARD HUGH PHILIP ,  VIEIRA ERIC ,  SPURR PAUL

IPC: C07D401/06 ,  A61K31/4439 ,  A61K31/444 ,  A61P25/22 ,  C07D401/14

Abstract: The present invention relates to diazole derivatives of the general formula (I) wherein A, E, R1, Wand R3 are as defined in the claims and description, their use for the preparation of medicaments for treating diseases and processes for preparing them.

公开(公告)号：NO332143B1

公开(公告)日：2012-07-02

申请号：NO20055465

申请日：2005-11-18

Applicant: HOFFMANN LA ROCHE

Inventor： KOLCZEWSKI SABINE ,  BUETTELMANN BERND ,  JAESCHKE GEORG ,  VIEIRA ERIC ,  CECCARELLI SIMONA MARIA ,  PORTER RICHARD HUGH PHILLIP

IPC: C07D401/14 ,  A61K31/4439 ,  A61P25/28 ,  C07D401/06

Abstract: The present invention relates to imidazole derivatives of formula I wherein R1, R2, R3 and R4 are described hereinabove. These compounds can be used in the treatment or prevention of mGluR5 receptor mediated disorders. These compounds are useful, inter alia, in the treatment or prevention of acute and/or chronic neurological disorders such as psychosis, epilepsy, schizophrenia, Alzheimer' disease, cognititve disorders and memory deficits, as well as chronic and acute pain.

公开(公告)号：CO6430459A2

公开(公告)日：2012-04-30

申请号：CO11116894

申请日：2011-09-09

Applicant: HOFFMANN LA ROCHE

Inventor： ALVAREZ SANCHEZ RUBEN ,  BANNER DAVID ,  CECCARELLI SIMONA MARIA ,  GRETHER UWE ,  HAAP WOLFGANG ,  HARTMAN PETER ,  HARTMAN GUIDO ,  HILPERT HANS ,  KUEHNE HOLGER ,  MAUSER HARALD ,  PLANCHER JEAN-MARC

IPC: C07D207/16

Abstract: La invención se refiere a un compuesto de la fórmula (I) en la que A, R1-R6 tienen los significados definidos en la descripción y en las reivindicaciones. El compuesto de la fórmula (I) puede utilizarse como medicamento.

公开(公告)号：CA2621404C

公开(公告)日：2012-01-24

申请号：CA2621404

申请日：2006-09-05

Applicant: HOFFMANN LA ROCHE

Inventor： ACKERMANN JEAN ,  BLEICHER KONRAD ,  CECCARELLI SIMONA MARIA ,  CHOMIENNE ODILE ,  MATTEI PATRIZIO ,  SCHULZ-GASCH TANJA

IPC: C07D209/10 ,  C07D215/58 ,  C07D223/16 ,  C07D403/12 ,  C07D413/12

Abstract: The invention is concerned with novel heterobicyclic derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPTl and can be used as medicaments.

公开(公告)号：CA2608837C

公开(公告)日：2011-08-02

申请号：CA2608837

申请日：2006-05-29

Applicant: HOFFMANN LA ROCHE

Inventor： BLEICHER KONRAD ,  CECCARELLI SIMONA MARIA ,  CHOMIENNE ODILE ,  MATTEI PATRIZIO ,  SCHULZ-GASCH TANJA ,  STAHL CHRISTOPH MARTIN

IPC: C07C311/21 ,  A61K31/196 ,  A61K31/42 ,  A61K31/505 ,  A61P3/10 ,  C07C311/29 ,  C07D409/04 ,  C07D413/04

Abstract: The invention is concerned with novel sulfonamide derivatives of Formula (I); wherein R2, R3, R4, A, X, Y1, Y2, Y3, Y4 and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.

公开(公告)号：BRPI0616246A2

公开(公告)日：2011-06-14

申请号：BRPI0616246

申请日：2006-09-05

Applicant: HOFFMANN LA ROCHE

Inventor： ACKERMANN JEAN ,  BLEICHER KONRAD ,  CECCARELLI SIMONA MARIA ,  MATTEI PATRIZIO ,  CHOMIENNE ODILE ,  SCHULZ-GASCH TANJA

IPC: C07D209/10 ,  C07D215/58 ,  C07D223/16 ,  C07D403/12 ,  C07D413/12

Abstract: The invention is concerned with novel heterobicyclic derivatives of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, A, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.

公开(公告)号：DE602006014139D1

公开(公告)日：2010-06-17

申请号：DE602006014139

申请日：2006-05-29

Applicant: HOFFMANN LA ROCHE

Inventor： BLEICHER KONRAD ,  CECCARELLI SIMONA MARIA ,  CHOMIENNE ODILE ,  MATTEI PATRIZIO ,  SCHULZ-GASCH TANJA ,  STAHL CHRISTOPH MARTIN

IPC: A61K31/196 ,  C07C311/21 ,  A61K31/42 ,  A61K31/505 ,  A61P3/10 ,  C07C311/29 ,  C07D409/04 ,  C07D413/04

公开(公告)号：MY140206A

公开(公告)日：2009-11-30

申请号：MYPI20042241

申请日：2004-06-10

Applicant: HOFFMANN LA ROCHE

Inventor： BUETTELMANN BERND ,  CECCARELLI SIMONA MARIA ,  JAESCHKE GEORG ,  KOLCZEWSKI SABINE ,  PORTER RICHARD HUGH PHILIP ,  VIEIRA ERIC

IPC: A61K31/5377 ,  A61P25/28 ,  C07D233/54 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D417/14

Abstract: THE PRESENT INVENTION RELATES TO IMIDAZOLE DERIVATIVES OF THE GENERAL FORMULA I WHEREIN R¹,R², R³AND R⁴ ARE AS DEFINED IN THE SPECIFICATION AS WELL AS TO PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND TO PROCESSES FOR THE PREPARATION THEREOF. THE INVENTION ALSO RELATES TO THE USE OF SAID IMIDAZOLE DERIVATIVES FOR THE PREPARATION OF MEDICAMENTS AND TO MEDICAMENTS CONTAINING THEM FOR THE PREVENTION OR THE TREATMENT OF MGLUR5 RECEPTOR MEDIATED DISORDERS, SUCH AS ACUTE AND/OR CHRONIC NEUROLOGICAL DISORDERS, IN PARTICULAR ANXIETY, OR FOR THE TREATMENT OF CHRONIC AND ACUTE PAIN.

公开(公告)号：BRPI0606644A2

公开(公告)日：2009-07-14

申请号：BRPI0606644

申请日：2006-01-09

Applicant: HOFFMANN LA ROCHE

Inventor： BUETTELMANN BERND ,  CECCARELLI SIMONA MARIA ,  JAESCHKE GEORG ,  KOLCZEWSKI SABINE ,  PORTER RICHARD HUGH PHILLIP ,  VIEIRA ERIC

IPC: C07D417/14 ,  A61K31/415 ,  A61K31/426 ,  A61P25/00 ,  C07D277/42 ,  C07D417/12 ,  C07D419/12

Abstract: The present invention is concerned with novel thiazole 4-carboxyamide derivatives of the general formula (I) and with methods for the preparation thereof, which compounds are useful as metabotropic glutamate receptor antagonists: wherein R1 to R4 are as defined in the specification.