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公开(公告)号:JP2010060558A
公开(公告)日:2010-03-18
申请号:JP2009188953
申请日:2009-08-18
Inventor: VOEGELIN DIETER , GRASSMANN OLAF
IPC: G01N1/28
CPC classification number: B01L3/50853 , B01L3/50855 , B01L9/52 , B01L2200/082 , B01L2300/041 , B01L2300/0887
Abstract: PROBLEM TO BE SOLVED: To provide a sample carrier (sample holder) of closeness with a simple structure and assembly for biologically active sample, in particular for toxic samples and especially for severe toxic samples. SOLUTION: The sample carrier 1 includes a bottom part 10, a first membrane 12, a spacer 13, a second membrane 14 and a lid 16. The bottom part 10 and the lid concerned 16 are connectable in such a way, that the first membrane 12, the spacer 13, and the second membrane 14 are enclosed between the bottom part 10 and the lid 16. The bottom part 10 and the lid 16 include a means for a non-detachable form-locking connection of the bottom part 10 and the lid 16. COPYRIGHT: (C)2010,JPO&INPIT
Abstract translation: 要解决的问题:提供具有生物活性样品的简单结构和组装的亲和性样品载体(样品保持器),特别是对于有毒样品,特别是对于严重有毒样品。 解决方案:样品载体1包括底部10,第一膜12,间隔物13,第二膜14和盖16.底部10和盖16可以这样的方式连接,即 第一膜12,间隔件13和第二膜14被封装在底部部分10和盖子16之间。底部部分10和盖子16包括用于底部部分10和盖子16的不可拆卸的形状锁定连接的装置 10和盖16。版权所有(C)2010,JPO&INPIT
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公开(公告)号:JP2006313157A
公开(公告)日:2006-11-16
申请号:JP2006127172
申请日:2006-05-01
Inventor: GRASSMANN OLAF , HENNIG MICHAEL , HOCHSTRASSER REMO A , SCHWITTER URS
IPC: G01N23/207
CPC classification number: G01N23/20
Abstract: PROBLEM TO BE SOLVED: To provide a method and device for X-ray transmission diffraction analysis remarkably improved in particle statistics.
SOLUTION: This method includes: a step for disposing a sample on a substrate; a step for generating a band-shaped X-ray beam with its center portion extending along a plane by an X-ray radiation source; a step for disposing the substrate and sample at initial positions where the sample stands in the route of the beam and a thin-leaf part of the sample is irradiated with the beam; a step for executing the following motions of the substrate with respect to the initial position of the substrate, that is, rotations around a rotation axis line vertical to the substrate being the rotations of the substrate and sample through a prescribed rotation angle, and tilting motions of the substrate and sample through an inclination angle defined as an angle between a plane with the center portion of the beam around a tilt axis line extending therein and the rotation axis line being tilting motions through the tilt angle changing between first and second prescribed values; and a step for detecting X-ray radiations transmitted and diffracted by the sample during a period between times at which the motions of the substrate are executed.
COPYRIGHT: (C)2007,JPO&INPITAbstract translation: 要解决的问题:提供一种在粒子统计中显着提高的X射线衍射分析方法和装置。 解决方案:该方法包括:将样品设置在基板上的步骤; 用于产生带状X射线束的步骤,其中心部分通过X射线辐射源沿着平面延伸; 将基板和样品设置在样品在梁的路径中的原始位置并且样品的薄叶部分用光束照射的步骤; 相对于基板的初始位置执行基板的以下运动的步骤,即,与基板垂直的旋转轴线周围的旋转是基板和样品的旋转,并且具有规定的旋转角度,以及倾斜运动 所述倾斜角定义为与围绕其延伸的倾斜轴线的光束的中心部分的平面之间的角度,并且所述旋转轴线是通过在第一和第二规定值之间变化的倾斜角度的倾斜运动; 以及用于在执行基板的运动的时间段期间检测由样品透射和衍射的X射线辐射的步骤。 版权所有(C)2007,JPO&INPIT
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公开(公告)号:WO2008138754A3
公开(公告)日:2009-01-22
申请号:PCT/EP2008055291
申请日:2008-04-30
Applicant: HOFFMANN LA ROCHE , ADAM JEAN-MICHEL , BUBENDORF ANDRE , DEYNET-VUCENOVIC ANNETTE , DOTT PASCAL , GLOMME ALEXANDER , GRASSMANN OLAF , HAAP WOLFGANG , KUENTZ MARTIN , MEIER ROLAND
Inventor: ADAM JEAN-MICHEL , BUBENDORF ANDRE , DEYNET-VUCENOVIC ANNETTE , DOTT PASCAL , GLOMME ALEXANDER , GRASSMANN OLAF , HAAP WOLFGANG , KUENTZ MARTIN , MEIER ROLAND
IPC: C07D401/14 , A61K31/4412 , A61P7/02
CPC classification number: C07D401/14
Abstract: The invention is concerned with crystalline forms or amorphous forms of a pyrrolidine- 3,4-dicarboxamide derivative, which is useful as an active ingredient of medicaments for the diseases which can be treated by the coagulation factor Xa inhibitors.
Abstract translation: 本发明涉及吡咯烷-3,4-二甲酰胺衍生物的结晶形式或无定形形式,其可用作可由凝血因子Xa抑制剂治疗的疾病的药物的活性成分。
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公开(公告)号:WO2009087062A3
公开(公告)日:2010-01-14
申请号:PCT/EP2008068219
申请日:2008-12-23
Applicant: HOFFMANN LA ROCHE , BUBENDORF ANDRE , GOLDBACH PIERRE , GRASSMANN OLAF , HENNIG MICHAEL , SAUER INES , TRUSSARDI RENE
Inventor: BUBENDORF ANDRE , GOLDBACH PIERRE , GRASSMANN OLAF , HENNIG MICHAEL , SAUER INES , TRUSSARDI RENE
IPC: C07C231/22 , C07C233/52
CPC classification number: C07C233/52 , C07C231/22
Abstract: The present invention relates to polymorphic forms of Oseltamivir phosphate, especially the (3R,4R,5S)-5-amino-4-acetylamino-3-(1-ethyl-propoxy)-cyclohex-1-ene-carboxylic acid ethyl ester phosphate, which is a potent inhibitor of viral neuraminidase.
Abstract translation: 本发明涉及磷酸奥司他韦的多晶型物,特别是(3R,4R,5S)-5-氨基-4-乙酰氨基-3-(1-乙基 - 丙氧基) - 环己-1-烯羧酸乙酯磷酸酯 ,其是病毒性神经氨酸酶的有效抑制剂。
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公开(公告)号:WO2006100181A3
公开(公告)日:2006-11-30
申请号:PCT/EP2006060589
申请日:2006-03-09
Applicant: HOFFMANN LA ROCHE , ABRECHT STEFAN , BUBENDORF ANDRE GERARD , GOETZOE STEPHAN , GRASSMANN OLAF , MONTAVON FRANCOIS , MOOG REGINA , ROHRER FRANZISKA , RUF ARMIN , SCALONE MICHELANGELO , SCHWITTER URS , WANG SHAONING
Inventor: ABRECHT STEFAN , BUBENDORF ANDRE GERARD , GOETZOE STEPHAN , GRASSMANN OLAF , MONTAVON FRANCOIS , MOOG REGINA , ROHRER FRANZISKA , RUF ARMIN , SCALONE MICHELANGELO , SCHWITTER URS , WANG SHAONING
IPC: C07D413/12 , A61K31/422 , A61P3/04 , A61P3/10
CPC classification number: C07D413/12
Abstract: The invention is concerned with (S)-l-{[2-(5-Methyl-2-phenyl-oxazol-4-yl)- ethylamino]-acetyl}-pyrrolidine-2-carbonitrile mesylate and crystalline polymorphs of this compound. This compound and its polymorphic forms exhibits superior properties compared to the previously known compounds and can be used as medicament for the treatment of disorders which are associated with DPP-IV.
Abstract translation: 本发明涉及该化合物的(S)-1 - {[2-(5-甲基-2-苯基 - 恶唑-4-基)乙基氨基] - 乙酰基} - 吡咯烷-2-甲磺酸酯和结晶多晶型物。 该化合物及其多晶型与先前已知的化合物相比表现出优异的性质,可用作治疗与DPP-IV相关的疾病的药物。
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公开(公告)号:MX384868B
公开(公告)日:2025-03-14
申请号:MX2018005890
申请日:2018-05-10
Applicant: HOFFMANN LA ROCHE
Inventor: MORAWSKI VIANNA EDUARDO PAULO , METZGER FRIEDRICH , ALSENZ JOCHEM , MCCARTHY KATHLEEN DOROTHY , WOODHOUSE MARVIN LLOYD , GRASSMANN OLAF , KUEHL PETER
IPC: A61K45/06 , A61K9/00 , A61K9/08 , A61K9/14 , A61K31/5025 , A61K31/575 , A61P25/28
Abstract: La proporciona composiciones farmacéuticas que comprenden un compuesto de fórmula (I) (ver Fórmula) en donde A, R1, R2 y R3 son como se describen en el presente documento así como sales farmacéuticamente aceptables de los mismos. Además, la presente invención se refiere a la fabricación de las composiciones farmacéuticas que comprenden un compuesto de fórmula (I) y sus usos como medicamentos.
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公开(公告)号:PL3077396T3
公开(公告)日:2021-10-04
申请号:PL14805290
申请日:2014-12-01
Applicant: HOFFMANN LA ROCHE
Inventor: ROTHENHAEUSLER BENNO , TRUSSARDI RENÉ , HOFFMANN-EMERY FABIENNE , SCHWITTER URS , ADAM JEAN-MICHEL , GRASSMANN OLAF , HARTUNG THOMAS , RAN FREDERIC , DIODONE RALPH , PFLEGER CHRISTOPHE , BARTELS BJOERN
IPC: C07D487/04 , A61K31/5517 , A61P25/00
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公开(公告)号:HRP20210966T1
公开(公告)日:2021-09-17
申请号:HRP20210966
申请日:2021-06-17
Applicant: HOFFMANN LA ROCHE
Inventor: ROTHENHAEUSLER BENNO , TRUSSARDI RENÉ , HOFFMANN-EMERY FABIENNE , SCHWITTER URS , ADAM JEAN-MICHEL , GRASSMANN OLAF , HARTUNG THOMAS , RAN FREDERIC , DIODONE RALPH , PFLEGER CHRISTOPHE , BARTELS BJOERN
IPC: C07D487/04 , A61K31/5517 , A61P25/00
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公开(公告)号:AU2019201183B2
公开(公告)日:2021-03-04
申请号:AU2019201183
申请日:2019-02-20
Applicant: HOFFMANN LA ROCHE
Inventor: ROTHENHAEUSLER BENNO , TRUSSARDI RENE , HOFFMANN-EMERY FABIENNE , SCHWITTER URS , ADAM JEAN-MICHEL , GRASSMANN OLAF , HARTUNG THOMAS , RAN FREDERIC , DIODONE RALPH , PFLEGER CHRISTOPHE , BARTELS BJOERN
IPC: C07D487/04 , A61K31/5517 , A61P25/00
Abstract: SYNTHESIS OF TRANS-8-CHLORO-5-METHYL-1-[4-(PYRIDIN-2-YLOXY) CYCLOHEXYL]-5,6-DIHYDRO-4H-2,3,5,IOB-TETRAAZA BENZO[E]AZULENE AND CRYTALLINE FORMS THEREOF Abstract 0, N The present invention provides processes to manufacture substituted 1-[4 (Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,I0b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
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公开(公告)号:HK1220203A1
公开(公告)日:2017-04-28
申请号:HK16108349
申请日:2016-07-15
Applicant: HOFFMANN LA ROCHE
Inventor: GRASSMANN OLAF , HILDBRAND STEFAN , MEIER ROLAND , SCALONE MICHELANGELO , SCHWITTER URS , WIRZ BEAT , ZUTTER ULRICH
IPC: C07D20060101
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