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公开(公告)号：PH21897A
公开(公告)日：1988-04-07
申请号：PH31733
申请日：1985-01-17
Applicant: HOFFMANN LA ROCHE
Inventor： FURLENMEIER ANDRE DR , HOFHEINZ WERNER DR , ISENRING HANS PETER DR , HUBSCHWERLEN CHRISTIAN NICOLAS
IPC: C07D205/085 , C07D263/48 , C07D277/20 , C07D403/12 , C07D405/04 , C07D413/12 , C07D417/12 , C07F7/08 , C07D205/04 , A61K31/395
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公开(公告)号：AU558627B2
公开(公告)日：1987-02-05
申请号：AU1506783
申请日：1983-05-30
Applicant: HOFFMANN LA ROCHE
Inventor： FURLENMEIER ANDRE , HOFHEINZ WERNER , HUBSCHWERLEN CHRISTIAN NICOLAS , ISENRING HANS PETER
IPC: A61K31/397 , A61K31/425 , A61K31/426 , A61K31/428 , A61P31/04 , C07D205/08 , C07D205/085 , C07D263/48 , C07D277/20 , C07D277/40 , C07D277/70 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07F7/08 , C07D213/73 , C07D233/88 , C07D277/74 , C07D285/08 , C07D401/12 , C07D401/14 , C07D403/14 , C07D413/14
Abstract: Antimicrobial 2-oxo-1-azetidinesulphonic acids of the formula in which H2N represents an amino-substituted thiazolyl group, R1 is lower alkyl which is substituted by carbamoyl, lower alkylsuphonyl, azido, piperidine-carbonyl, (hexahydro-1H-azepin-1-yl)carbonyl or lower alkynyl, and R2 is hydrogen or a lower organic group, typically, carbamoyloxymethyl.
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公开(公告)号：ZA8303887B
公开(公告)日：1984-11-28
申请号：ZA8303887
申请日：1983-05-27
Applicant: HOFFMANN LA ROCHE
Inventor： FURLENMEIER ANDRE , HOFHEINZ WERNER , HUBSCHWERLEN CHRISTIAN NICOLAS , ISENRING HANS PETER
IPC: C07D401/12 , A61K20060101 , A61K31/397 , A61K31/41 , A61K31/415 , A61K31/425 , A61K31/433 , A61P31/04 , B01J23/44 , B01J27/13 , B01J27/16 , C07B61/00 , C07D20060101 , C07D205/08 , C07D205/085 , C07D213/55 , C07D213/73 , C07D231/12 , C07D233/88 , C07D263/00 , C07D263/48 , C07D277/00 , C07D277/20 , C07D277/40 , C07D277/74 , C07D285/08 , C07D403/12 , C07D413/12 , C07D417/12 , C07D419/12 , C07D521/00 , C07F7/18 , C07D , A61K
CPC classification number: Y02A50/473
Abstract: Title compds. I [Het=aromatic heterocycle R1=H, alkyl, alkanoyl, R2=H, alkenyl, are prepd. Thus, 2-[5-(1-tertiany -butoxyformamide)- 3-(1,2,4-thiacliazolyl) -2-[[(Z)-(tertiarybutoxycarbonyl) methoxyl imino!acetate 2-benzthiazollyl thio ester is treated with 1- chloro-N, N, 2-trimethyl-1-propenamine, triethyl amine, and (3S,4S)- 3-amino-4-carbamoyloxymethyl)-2-oxo-1-azetidine sulfonate. After stirring and evaporating, the resulting residue is reacted with NaHCO3 to give (3S,4S)-3-[(Z)-2-(5-amino-1,2,4thiadiazol-3-yl)-2- [[(t-butoxycarbonyl)methoxy imino!acetamido!4-carbamoyloxymethyl-2- oxo-1-azetidine sulfonate.
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公开(公告)号：DK241883A
公开(公告)日：1983-12-04
申请号：DK241883
申请日：1983-05-27
Applicant: HOFFMANN LA ROCHE
Inventor： FURLENMEIER ANDRE , HOFHEINZ WERNER , HUBSCHWERLEN CHRISTIAN NICOLAS , ISENRING HANS PETER
IPC: C07D205/085 , C07D263/48 , C07D277/20 , C07D403/12 , C07D405/04 , C07D413/12 , C07D417/12 , C07F7/08 , C07D , C07F
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公开(公告)号：NO822902A
公开(公告)日：1983-02-28
申请号：NO822902
申请日：1982-08-26
Applicant: HOFFMANN LA ROCHE
Inventor： HUBSCHWERLEN CHRISTIAN NICOLAS , SCHMID GERARD
IPC: C07D205/08 , C07D205/085 , C07D277/40 , C07D317/28 , C07D317/36 , C07D317/72 , C07D319/12 , C07D403/04 , C07D405/04 , C07D405/14 , C07D493/14 , C07D
CPC classification number: C07D317/72 , C07D205/085 , C07D277/40 , C07D317/28 , C07D403/04 , C07D405/14 , C07D493/14 , Y02P20/55
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Patent Agency Ranking
公开(公告)号：AU576951B2
公开(公告)日：1988-09-08
申请号：AU5467186
申请日：1986-03-12
Applicant: HOFFMANN LA ROCHE
Inventor： HUBSCHWERLEN CHRISTIAN NICOLAS , SCHMID GERARD
IPC: C07D205/08 , C07D205/085 , C07D277/40 , C07D317/28 , C07D317/36 , C07D317/72 , C07D319/12 , C07D403/04 , C07D405/04 , C07D405/14 , C07D493/14 , C07D317/38
Abstract: There is presented optically uniform beta -lactams of the formulae wherein Z is a readily cleavable acyl group, R1 is amino or a group convertible into amino, R2 is hydrogen or a readily cleavable protecting group and R3 and R4 each are a lower hydrocarbon group which optionally contains oxygen and which is attached via a carbon atom, whereby these groups can also be joined with one another to form a ring, with the proviso that R1 is a readily cleavable acylamino when R2 is hydrogen, and the corresponding optical antipodes, their manufacture and use in the manufacture of antimicrobially-active beta -lactams as well as novel intermediates usable in their manufacture.
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公开(公告)号：DE3277410D1
公开(公告)日：1987-11-05
申请号：DE3277410
申请日：1982-08-25
Applicant: HOFFMANN LA ROCHE
Inventor： HUBSCHWERLEN CHRISTIAN NICOLAS , SCHMID GERARD DR
IPC: C07D205/08 , C07D205/085 , C07D277/40 , C07D317/28 , C07D317/36 , C07D317/72 , C07D319/12 , C07D403/04 , C07D405/04 , C07D405/14 , C07D493/14 , C07C119/06
Abstract: There is presented optically uniform beta -lactams of the formulae wherein Z is a readily cleavable acyl group, R1 is amino or a group convertible into amino, R2 is hydrogen or a readily cleavable protecting group and R3 and R4 each are a lower hydrocarbon group which optionally contains oxygen and which is attached via a carbon atom, whereby these groups can also be joined with one another to form a ring, with the proviso that R1 is a readily cleavable acylamino when R2 is hydrogen, and the corresponding optical antipodes, their manufacture and use in the manufacture of antimicrobially-active beta -lactams as well as novel intermediates usable in their manufacture.
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公开(公告)号：AU558593B2
公开(公告)日：1987-02-05
申请号：AU1506883
申请日：1983-05-30
Applicant: HOFFMANN LA ROCHE
Inventor： FURLENMEIER ANDRE , HOFHEINZ WERNER , HUBSCHWERLEN CHRISTIAN NICOLAS , ISENRING HANS PETER
IPC: C07D205/085 , C07D263/48 , C07D277/20 , C07D403/12 , C07D405/04 , C07D413/12 , C07D417/12 , C07F7/08 , C07F7/18 , A61K31/395 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/695 , C07D213/73 , C07D231/12 , C07D233/88 , C07D277/30 , C07D277/40 , C07D277/74 , C07D285/08 , C07D401/12
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公开(公告)号：PH18877A
公开(公告)日：1985-10-22
申请号：PH29003
申请日：1983-06-02
Applicant: HOFFMANN LA ROCHE
Inventor： FURLENMEIER ANDRE DR , HOFHEINZ WERNER DR , ISENRING HANS PETER DR , HUBSCHWERLEN CHRISTIAN NICOLAS
IPC: C07D205/085 , C07D263/48 , C07D277/20 , C07D403/12 , C07D405/04 , C07D413/12 , C07D417/12 , C07F7/08 , C07D231/42 , A61K31/535
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公开(公告)号：AU1506883A
公开(公告)日：1983-12-15
申请号：AU1506883
申请日：1983-05-30
Applicant: HOFFMANN LA ROCHE
Inventor： FURLENMEIER ANDRE , HOFHEINZ WERNER , HUBSCHWERLEN CHRISTIAN NICOLAS , ISENRING HANS PETER
IPC: C07D205/085 , C07D263/48 , C07D277/20 , C07D403/12 , C07D405/04 , C07D413/12 , C07D417/12 , C07F7/08 , A61K31/395 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/695 , C07D7/18 , C07D277/40 , C07D277/74 , C07D285/08 , C07D401/12
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