公开(公告)号：US3850912A

公开(公告)日：1974-11-26

申请号：US40495673

申请日：1973-10-10

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  FLIRI H ,  KLOTZER W

IPC: C07D239/46 ,  C07D239/52 ,  C07D239/54 ,  C07D239/56 ,  C07D239/69 ,  A61K27/00 ,  C07D5/34

CPC classification number: C07D239/47 ,  C07D239/54 ,  C07D239/56 ,  C07D239/69

Abstract: 1. A SULFANILAMIDE OF THE FORMULA

1-(R-O-),2-(O=),4-(H2N-(1,4-PHENYLENE)-SO2-NH-)-1,2-

DIHYDROPYRIMIDINE

WHERE R IS LOWER ALKTL, ALLYL OR LOWER ALKOXYL-LOWER ALKYL AND PHARMACEUTICALLY ACCEPTABLE ALKALI METAL SALTS AND SALTS WITH STRONG ORGANIC BASES THEREOF.

公开(公告)号：US3812170A

公开(公告)日：1974-05-21

申请号：US18783471

申请日：1971-10-08

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  KLOTZER W ,  FRANZMAIR R

IPC: C07C275/24 ,  C07D207/22 ,  C07D207/26 ,  C07C121/78

CPC classification number: C07D207/26 ,  C07C275/24 ,  C07D207/22 ,  Y10S514/866

Abstract: NOVEL 2-IMINOPYRROLIDINES SUBSTITUTED IN THE 1-POSITION ARE PREPARED FROM 2-AMINO-$''-PYROOLINES. THE NOVEL PYRROLIDINES ARE USEFUL AS ANTI-DIABETIC AND HYPOGLYCEMIC AGENTS SINCE THEY EFFECT A LOWERING OF THE BLOOD SUGAR CONTENT IN WARM BLOODED ANIMALS.

公开(公告)号：BR6911331D0

公开(公告)日：1973-02-13

申请号：BR21133169

申请日：1969-08-06

Applicant: HOFFMANN LA ROCHE

Inventor： FRANZMAIR R ,  BRETSCHNEIDER H ,  KLOTZER W

IPC: C07D207/22 ,  C07D207/26 ,  C07D27/04

公开(公告)号：BR6911330D0

公开(公告)日：1973-02-13

申请号：BR21133069

申请日：1969-08-06

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  SCHMIDT B ,  KLOTZER W ,  FRANZMAIR R

IPC: C07D207/22

公开(公告)号：DK129657C

公开(公告)日：1975-04-07

申请号：DK83473

申请日：1973-02-16

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  KLOTZER W ,  BADER G ,  LUTZ A

IPC: A61K31/415 ,  A61P3/08 ,  C07D207/22 ,  C07D403/12 ,  C07D487/14

Abstract: 3-Methyl-N-(1-pyrrolin-2-yl)-pyrazole-5-carboxamides and processes for making same. Such compounds lower blood sugar and, hence, are useful as antidiabetic agents.

公开(公告)号：SE410315B

公开(公告)日：1979-10-08

申请号：SE7302660

申请日：1973-02-26

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  KLOTZER W ,  BADER G ,  LUTZ A

IPC: A61K31/415 ,  A61P3/08 ,  C07D207/22 ,  C07D403/12 ,  C07D487/14 ,  C07D231/12

Abstract: 3-Methyl-N-(1-pyrrolin-2-yl)-pyrazole-5-carboxamides and processes for making same. Such compounds lower blood sugar and, hence, are useful as antidiabetic agents.