公开(公告)号：US3772413A

公开(公告)日：1973-11-13

申请号：US3772413D

申请日：1971-10-08

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  KLOETZER W ,  FRANZMAIR R

IPC: C07D207/22 ,  C07D207/26 ,  C07D27/04

CPC classification number: C07D207/26 ,  C07D207/22 ,  Y10S514/866

Abstract: NOVEL 2-IMINOPYRROLIDINES SUBSTITUTED IN THE 1-POSITION ARE PREPARED FROM 2-AMINO-$''-PYRROLINES. THE NOVEL PYRROLIDINES ARE USEFUL AS ANTI-DIABETIC AND HYPOGLYCEMIC AGENTS SINCE THEY EFFECT A LOWERING OF THE BLOOD SUGAR CONTENT IN WARM BLOODED ANIMALS.

公开(公告)号：US3812170A

公开(公告)日：1974-05-21

申请号：US18783471

申请日：1971-10-08

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  KLOTZER W ,  FRANZMAIR R

IPC: C07C275/24 ,  C07D207/22 ,  C07D207/26 ,  C07C121/78

CPC classification number: C07D207/26 ,  C07C275/24 ,  C07D207/22 ,  Y10S514/866

Abstract: NOVEL 2-IMINOPYRROLIDINES SUBSTITUTED IN THE 1-POSITION ARE PREPARED FROM 2-AMINO-$''-PYROOLINES. THE NOVEL PYRROLIDINES ARE USEFUL AS ANTI-DIABETIC AND HYPOGLYCEMIC AGENTS SINCE THEY EFFECT A LOWERING OF THE BLOOD SUGAR CONTENT IN WARM BLOODED ANIMALS.

公开(公告)号：NO128275B

公开(公告)日：1973-10-22

申请号：NO332668

申请日：1968-08-26

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  KLOETZER W ,  FRANZMAIR R ,  SCHMIDT B

IPC: C07D27/14

公开(公告)号：NO129571B

公开(公告)日：1974-04-29

申请号：NO332768

申请日：1968-08-26

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  KLOETZER W ,  FRANZMAIR R

IPC: C07D27/04

公开(公告)号：BR6911331D0

公开(公告)日：1973-02-13

申请号：BR21133169

申请日：1969-08-06

Applicant: HOFFMANN LA ROCHE

Inventor： FRANZMAIR R ,  BRETSCHNEIDER H ,  KLOTZER W

IPC: C07D207/22 ,  C07D207/26 ,  C07D27/04

公开(公告)号：SE340620B

公开(公告)日：1971-11-29

申请号：SE1150468D

申请日：1968-08-27

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  KLOETZER W ,  FRANZMAIR R ,  SCHMIDT B

IPC: C07D207/22 ,  C07D207/38 ,  C07D27/14

Abstract: (A) Cmpds. (I) and (III): and tautomeric forms of I and III, where R' = Ph opt. substd. by (1-6Ce alkyl, (1-6C) Oalkyl, or halogen. R2 = Ph opt. substd. by (1-6C) alkyl, (1-6C)O alkyl, or halogen, (5-6C) cycloalkyl, or (5-6C) cycloalkenyl. R3, R4, R5 and R6 = H or (1-6C) alkyl. R7 = H, (1-6C) alkyl, lower carbalkoxy, lower alkyl, N(alkyl)2-lower alkyl, lower alkoxyphenyl, or lower alkoxy-lower alkyl. R8 = H or (1-6C) alkyl. X = O, S, or NH. (B) Acid addn. salts (II) of I. I and II Hypoglycaemics. III Intermediates for I.

公开(公告)号：SE340454B

公开(公告)日：1971-11-22

申请号：SE1150568D

申请日：1968-08-27

Applicant: HOFFMANN LA ROCHE

Inventor： FRANZMAIR R ,  BRETSCHNEIDER H ,  KLOETZER W

IPC: C07D27/04

公开(公告)号：BR6911330D0

公开(公告)日：1973-02-13

申请号：BR21133069

申请日：1969-08-06

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  SCHMIDT B ,  KLOTZER W ,  FRANZMAIR R

IPC: C07D207/22

公开(公告)号：NO125927B

公开(公告)日：1972-11-27

申请号：NO69968

申请日：1968-02-26

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  SCHMIDT B ,  FRANZMAIR R ,  KLOETZER W

IPC: C07D207/22 ,  C07D207/38 ,  C07D27/14

Abstract: (A) Cmpds. (I) and (III): and tautomeric forms of I and III, where R' = Ph opt. substd. by (1-6Ce alkyl, (1-6C) Oalkyl, or halogen. R2 = Ph opt. substd. by (1-6C) alkyl, (1-6C)O alkyl, or halogen, (5-6C) cycloalkyl, or (5-6C) cycloalkenyl. R3, R4, R5 and R6 = H or (1-6C) alkyl. R7 = H, (1-6C) alkyl, lower carbalkoxy, lower alkyl, N(alkyl)2-lower alkyl, lower alkoxyphenyl, or lower alkoxy-lower alkyl. R8 = H or (1-6C) alkyl. X = O, S, or NH. (B) Acid addn. salts (II) of I. I and II Hypoglycaemics. III Intermediates for I.